Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sneha Adusumilli"'
Autor:
Carlos G. Vanoye, Reshma R. Desai, Zhigang Ji, Sneha Adusumilli, Nirvani Jairam, Nora Ghabra, Nishtha Joshi, Eryn Fitch, Katherine L. Helbig, Dianalee McKnight, Amanda S. Lindy, Fanggeng Zou, Ingo Helbig, Edward C. Cooper, Alfred L. George Jr.
Publikováno v:
JCI Insight, Vol 7, Iss 5 (2022)
Hundreds of genetic variants in KCNQ2 encoding the voltage-gated potassium channel KV7.2 are associated with early onset epilepsy and/or developmental disability, but the functional consequences of most variants are unknown. Absent functional annotat
Externí odkaz:
https://doaj.org/article/3ca0b7a7c21f4302b4b8b629aef4802b
Autor:
Georg Kuenze, Carlos G Vanoye, Reshma R Desai, Sneha Adusumilli, Kathryn R Brewer, Hope Woods, Eli F McDonald, Charles R Sanders, Alfred L George Jr, Jens Meiler
Publikováno v:
eLife, Vol 9 (2020)
The function of the voltage-gated KCNQ1 potassium channel is regulated by co-assembly with KCNE auxiliary subunits. KCNQ1-KCNE1 channels generate the slow delayed rectifier current, IKs, which contributes to the repolarization phase of the cardiac ac
Externí odkaz:
https://doaj.org/article/eb5503437d7d4717b295c6786fb43fec
Publikováno v:
Journal of the Endocrine Society.
Diabetes rates in the United States are staggering and climbing. Importantly, traditional risk factors fail to completely account for the magnitude of the diabetes epidemic. Environmental exposures, including urban and metropolitan transportation qua
Autor:
Georg Kuenze, Carlos G. Vanoye, Mason C. Wilkinson, Reshma R. Desai, Sneha Adusumilli, Charles R. Sanders, Alfred L. George, Jens Meiler
The voltage-gated potassium channel KCNQ1 (KV7.1) is important for the repolarizing phase of the cardiac action potential. Activators of KCNQ1 may provide a strategy for the pharmacological treatment of congenital long QT syndrome, a genetic disorder
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ddb51d78639b0d4eb552b681ceef5e0
https://doi.org/10.1101/2022.05.31.494217
https://doi.org/10.1101/2022.05.31.494217
Autor:
Yo-Chuen Lin, Dazhen Liu, Arindam Chakraborty, Lyudmila Y. Kadyrova, You Jin Song, Qinyu Hao, Jaba Mitra, Rosaline Y. C. Hsu, Mariam K. Arif, Sneha Adusumilli, Ting-Wei Liao, Taekjip Ha, Farid A. Kadyrov, Kannanganattu V. Prasanth, Supriya G. Prasanth
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(22)
In eukaryotes, the origin recognition complex (ORC) is required for the initiation of DNA replication. The smallest subunit of ORC, Orc6, is essential for prereplication complex (pre-RC) assembly and cell viability in yeast and for cytokinesis in met
Autor:
Z. Ji, E. Fitch, N. Ghabra, J. Nishtha, Dianalee McKnight, Ingo Helbig, Amanda Lindy, Edward C. Cooper, N. Jairam, Alfred L. George, Sneha Adusumilli, F. Zou, Carlos G. Vanoye, Reshma R. Desai, Kimberly Helbig
Publikováno v:
JCI Insight. 7
Hundreds of KCNQ2 variants have been identified by genetic testing of children with early onset epilepsy and/or developmental disability. Voltage-clamp recording from heterologous cells has proved useful for establishing deleterious functional effect
Autor:
Sneha Adusumilli, Hope Woods, Charles R. Sanders, Jens Meiler, Georg Kuenze, Carlos G. Vanoye, Reshma R. Desai, Eli Fritz McDonald, Alfred G. George, Kathryn R. Brewer
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
The function of the voltage-gated KCNQ1 potassium channel is regulated by co-assembly with KCNE auxiliary subunits. KCNQ1-KCNE1 channels generate the slow delayed rectifier current, IKs, which contributes to the repolarization phase of the cardiac ac
Autor:
Charles R. Sanders, Sneha Adusumilli, Eli Fritz McDonald, Jens Meiler, Hope Woods, Kathryn R. Brewer, Carlos G. Vanoye, Reshma R. Desai, Georg Kuenze, Alfred L. George
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6e8f51521c058ddd362cb8820e66236
https://doi.org/10.7554/elife.57680.sa2
https://doi.org/10.7554/elife.57680.sa2