Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Sneha, Sant"'
Autor:
Zhi Ling Teo, Mark J. O’Connor, Stephanie Versaci, Kylie A. Clarke, Emmaline R. Brown, Luke W. Percy, Keilly Kuykhoven, Christopher P. Mintoff, Peter Savas, Balaji Virassamy, Stephen J. Luen, Ann Byrne, Sneha Sant, Geoffrey J. Lindeman, Phillip K. Darcy, Sherene Loi
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-16 (2023)
Abstract Novel therapeutic strategies that can effectively combine with immunotherapies are needed in the treatment of triple-negative breast cancer (TNBC). We demonstrate that combined PARP and WEE1 inhibition are synergistic in controlling tumour g
Externí odkaz:
https://doaj.org/article/bce6df774b064a2787512a67c74201f2
Autor:
Thi H. O. Nguyen, Marios Koutsakos, Carolien E. van de Sandt, Jeremy Chase Crawford, Liyen Loh, Sneha Sant, Ludivine Grzelak, Emma K. Allen, Tim Brahm, E. Bridie Clemens, Maria Auladell, Luca Hensen, Zhongfang Wang, Simone Nüssing, Xiaoxiao Jia, Patrick Günther, Adam K. Wheatley, Stephen J. Kent, Malet Aban, Yi-Mo Deng, Karen L. Laurie, Aeron C. Hurt, Stephanie Gras, Jamie Rossjohn, Jane Crowe, Jianqing Xu, David Jackson, Lorena E. Brown, Nicole La Gruta, Weisan Chen, Peter C. Doherty, Stephen J. Turner, Tom C. Kotsimbos, Paul G. Thomas, Allen C. Cheng, Katherine Kedzierska
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The immunological parameters that define severe influenza disease are not clear within human real time infections. Here the authors compare a severe influenza infection cohort with an influenza vaccinated cohort to understand correlates of severe inf
Externí odkaz:
https://doaj.org/article/2bb8c377813f4ec9954ac0d874794b8f
Autor:
Sneha Sant, Sergio M Quiñones-Parra, Marios Koutsakos, Emma J Grant, Thomas Loudovaris, Stuart I Mannering, Jane Crowe, Carolien E van de Sandt, Guus F Rimmelzwaan, Jamie Rossjohn, Stephanie Gras, Liyen Loh, Thi H O Nguyen, Katherine Kedzierska
Publikováno v:
PLoS Pathogens, Vol 16, Iss 8, p e1008714 (2020)
Seasonal influenza virus infections cause 290,000-650,000 deaths annually and severe morbidity in 3-5 million people. CD8+ T-cell responses towards virus-derived peptide/human leukocyte antigen (HLA) complexes provide the broadest cross-reactive immu
Externí odkaz:
https://doaj.org/article/4f5cecab80b948f2841becd5ebd204c2
Autor:
Emma J. Grant, Tracy M. Josephs, Liyen Loh, E. Bridie Clemens, Sneha Sant, Mandvi Bharadwaj, Weisan Chen, Jamie Rossjohn, Stephanie Gras, Katherine Kedzierska
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Mutations within immunological epitope containing regions of influenza A virus can impair the established immune response between influenza strains and could impact rational vaccine design. Here Grant et al. examine the presence, structural impact an
Externí odkaz:
https://doaj.org/article/e3208577560a455ba744a1baab24971d
Autor:
Bonnie van Wilgenburg, Liyen Loh, Zhenjun Chen, Troi J. Pediongco, Huimeng Wang, Mai Shi, Zhe Zhao, Marios Koutsakos, Simone Nüssing, Sneha Sant, Zhongfang Wang, Criselle D’Souza, Xiaoxiao Jia, Catarina F. Almeida, Lyudmila Kostenko, Sidonia B. G. Eckle, Bronwyn S. Meehan, Axel Kallies, Dale I. Godfrey, Patrick C. Reading, Alexandra J. Corbett, James McCluskey, Paul Klenerman, Katherine Kedzierska, Timothy S. C. Hinks
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
MAIT cells are abundant in the lungs and confer protection against bacterial pathogens. Whilst activation of these cells has been described during viral infections, here van Wilgenburg and colleagues show that in a murine model MAIT cells contribute
Externí odkaz:
https://doaj.org/article/e15ac8dd044648a69319eb56458d539f
Autor:
Zhongfang Wang, Lingyan Zhu, Thi H. O. Nguyen, Yanmin Wan, Sneha Sant, Sergio M. Quiñones-Parra, Jeremy Chase Crawford, Auda A. Eltahla, Simone Rizzetto, Rowena A. Bull, Chenli Qiu, Marios Koutsakos, E. Bridie Clemens, Liyen Loh, Tianyue Chen, Lu Liu, Pengxing Cao, Yanqin Ren, Lukasz Kedzierski, Tom Kotsimbos, James M. McCaw, Nicole L. La Gruta, Stephen J. Turner, Allen C. Cheng, Fabio Luciani, Xiaoyan Zhang, Peter C. Doherty, Paul G. Thomas, Jianqing Xu, Katherine Kedzierska
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Virus-specific CD8+ T cells are crucial during H7N9 influenza infection, but CD8+ T cell dysfunction is associated with poor prognosis. Here, the authors use molecular and phenotypic analysis to establish persistence of clonally diverse CD8+ T cell p
Externí odkaz:
https://doaj.org/article/0354e26df1f7459caf4dc1fcf140649a
Autor:
Amy L. Winship, Lauren R. Alesi, Sneha Sant, Jessica M. Stringer, Aldana Cantavenera, Teharn Hegarty, Carolina Lliberos Requesens, Seng H. Liew, Urooza Sarma, Meaghan J. Griffiths, Nadeen Zerafa, Stephen B. Fox, Emmaline Brown, Franco Caramia, Pirooz Zareie, Nicole L. La Gruta, Kelly-Anne Phillips, Andreas Strasser, Sherene Loi, Karla J. Hutt
Publikováno v:
Nature Cancer. 3:1-13
Loss of fertility is a major concern for female reproductive-age cancer survivors, since a common side-effect of conventional cytotoxic cancer therapies is permanent damage to the ovary. While immunotherapies are increasingly becoming a standard of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5921ffaf7787f14ee404e6e7845c9f
https://doi.org/10.1038/s43018-022-00413-x
https://doi.org/10.1038/s43018-022-00413-x
Autor:
Sneha Sant, Misty R Jenkins, Pradyot Dash, Katherine A Watson, Zhongfang Wang, Angela Pizzolla, Marios Koutsakos, Thi HO Nguyen, Martha Lappas, Jane Crowe, Tom Loudovaris, Stuart I Mannering, Glen P Westall, Tom C Kotsimbos, Allen C Cheng, Linda Wakim, Peter C Doherty, Paul G Thomas, Liyen Loh, Katherine Kedzierska
Publikováno v:
Clinical & Translational Immunology, Vol 8, Iss 9, Pp n/a-n/a (2019)
Abstract Background Although γδ T cells comprise up to 10% of human peripheral blood T cells, questions remain regarding their role in disease states and T‐cell receptor (TCR) clonal expansions. We dissected anti‐viral functions of human γδ T
Externí odkaz:
https://doaj.org/article/7ff1b72faa64454082fb640c16d1ffe8
Autor:
Ran Li, Sneha Sant, Emmaline Brown, Franco Caramia, Bronte Nikolic, Kylie Clarke, Ann Byrne, Luis E Lara Gonzalez, Peter Savas, Stephen J Luen, Zhi Ling Teo, Balaji Virassamy, Paul J Neeson, Phillip K Darcy, Sherene Loi
Publikováno v:
JNCI: Journal of the National Cancer Institute.
Background PD-1 and PD-L1 inhibitors have poor efficacy in patients with trastuzumab-resistant advanced HER2-positive breast cancer. Tucatinib is a potent, selective anti-HER2 tyrosine kinase inhibitor with proven clinical benefit in the advanced set
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::449f7ed88a651032c0dacbf89a7c7c04
https://doi.org/10.1093/jnci/djad072
https://doi.org/10.1093/jnci/djad072
Autor:
Sneha Sant, Ludivine Grzelak, Zhongfang Wang, Angela Pizzolla, Marios Koutsakos, Jane Crowe, Thomas Loudovaris, Stuart I. Mannering, Glen P. Westall, Linda M. Wakim, Jamie Rossjohn, Stephanie Gras, Michael Richards, Jianqing Xu, Paul G. Thomas, Liyen Loh, Thi H. O. Nguyen, Katherine Kedzierska
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
CD8+ T cells recognizing antigenic peptides derived from conserved internal viral proteins confer broad protection against distinct influenza viruses. As memory CD8+ T cells change throughout the human lifetime and across tissue compartments, we inve
Externí odkaz:
https://doaj.org/article/1d5bd61c37df45bdbdb857954b9db2b6