Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions

Autor: Steinparzer, Iris, Sedlyarov, Vitaly, Rubin, Jonathan D., Eislmayr, Kevin, Galbraith, Matthew D., Levandowski, Cecilia B., Vcelkova, Terezia, Sneezum, Lucy, Wascher, Florian, Amman, Fabian, Kleinova, Renata, Bender, Heather, Andrysik, Zdenek, Espinosa, Joaquin M., Superti-Furga, Giulio, Dowell, Robin D., Taatjes, Dylan J., Kovarik, Pavel

Publikováno v: In Molecular Cell 7 November 2019 76(3):485-499

Transcriptional responses to IFN-γ require Mediator kinase-dependent pause release and mechanistically distinct functions of CDK8 and CDK19

Autor: Steinparzer, Iris, Sedlyarov, Vitaly, Rubin, Jonathan D., Eislmayr, Kevin, Galbraith, Matthew D., Levandowski, Cecilia B., Vcelkova, Terezia, Sneezum, Lucy, Wascher, Florian, Amman, Fabian, Kleinova, Renata, Bender, Heather, Andrysik, Zdenek, Espinosa, Joaquin M., Superti-Furga, Giulio, Dowell, Robin D., Taatjes, Dylan J., Kovarik, Pavel

Publikováno v: Mol Cell

Transcriptional responses to external stimuli remain poorly understood. Using global nuclear run-on followed by sequencing (GRO-seq) and precision nuclear run-on sequencing (PRO-seq), we show that CDK8 kinase activity promotes RNA polymerase II pause

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2f5323fc9ec7e6f8b6c3a4ae782e2328
https://europepmc.org/articles/PMC6842433/

Tristetraprolin binding site atlas in the macrophage transcriptome reveals a switch for inflammation resolution.

Autor: Sedlyarov V; Max F. Perutz Laboratories, University of Vienna, Vienna, Austria., Fallmann J; Institute for Theoretical Chemistry, University of Vienna, Vienna, Austria., Ebner F; Max F. Perutz Laboratories, University of Vienna, Vienna, Austria., Huemer J; Max F. Perutz Laboratories, University of Vienna, Vienna, Austria., Sneezum L; Max F. Perutz Laboratories, University of Vienna, Vienna, Austria., Ivin M; Max F. Perutz Laboratories, University of Vienna, Vienna, Austria., Kreiner K; Max F. Perutz Laboratories, University of Vienna, Vienna, Austria., Tanzer A; Institute for Theoretical Chemistry, University of Vienna, Vienna, Austria., Vogl C; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria., Hofacker I; Institute for Theoretical Chemistry, University of Vienna, Vienna, Austria Research Group Bioinformatics and Computational Biology, Faculty of Computer Science, University of Vienna, Vienna, Austria Center for non-coding RNA in Technology and Health, University of Copenhagen, Frederiksberg C, Denmark ivo.hofacker@univie.ac.at pavel.kovarik@univie.ac.at., Kovarik P; Max F. Perutz Laboratories, University of Vienna, Vienna, Austria ivo.hofacker@univie.ac.at pavel.kovarik@univie.ac.at.

Publikováno v: Molecular systems biology [Mol Syst Biol] 2016 May 13; Vol. 12 (5), pp. 868. Date of Electronic Publication: 2016 May 13.