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Pteridine reductase (PTR1): initial structure-activity relationships studies of potential leishmanicidal arylindole derivatives compounds.

Autor: Silva JV; Department of Pharmacy, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Sueyoshi S; Department of Pharmacy, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Snape TJ; Leicester School of Pharmacy, De Montfort University, Leicester, UK., Lal S; Amity Institute of Pharmacy, Amity University, Gurugram, India., Giarolla J; Department of Pharmacy, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.

Publikováno v: SAR and QSAR in environmental research [SAR QSAR Environ Res] 2023 Jul-Sep; Vol. 34 (8), pp. 661-687. Date of Electronic Publication: 2023 Aug 22.

2,3-Diarylindoles as COX-2 Inhibitors: Exploring the Structure-activity Relationship through Molecular Docking Simulations.

Autor: Cuppoloni A; Department of Pharmacy, School of Pharmaceutical Sciences, University of Sao Paulo, São Paulo, Brazil., Silva JV; Department of Pharmacy, School of Pharmaceutical Sciences, University of Sao Paulo, São Paulo, Brazil., Snape TJ; Leicester School of Pharmacy, De Montfort University, Leicester, LE1 9BH, UK., Lal S; Amity Institute of Pharmacy, Samridhi Lal, Amity University, Gurugram, India., Giarolla J; Department of Pharmacy, School of Pharmaceutical Sciences, University of Sao Paulo, São Paulo, Brazil.

Publikováno v: Current topics in medicinal chemistry [Curr Top Med Chem] 2023; Vol. 23 (12), pp. 1081-1089.

Linearized esculentin-2EM shows pH dependent antibacterial activity with an alkaline optimum.

Autor: Malik E; College of Medicine and Health, University of Exeter Medical School, Heavitree Road, Exeter, EX1 2LU, UK., Phoenix DA; Office of the Vice Chancellor, London South Bank University, 103 Borough Road, London, SE1 0AA, UK., Snape TJ; School of Pharmacy, De Montfort University, Leicester, LE1 9BH, UK., Harris F; School of Natural Sciences, University of Central Lancashire, Preston, PR1 2HE, UK., Singh J; School of Natural Sciences, University of Central Lancashire, Preston, PR1 2HE, UK., Morton LHG; School of Natural Sciences, University of Central Lancashire, Preston, PR1 2HE, UK., Dennison SR; School of Pharmacy and Biological Sciences, University of Central Lancashire, Preston, PR1 2HE, UK. srdennison1@uclan.ac.uk.

Publikováno v: Molecular and cellular biochemistry [Mol Cell Biochem] 2021 Oct; Vol. 476 (10), pp. 3729-3744. Date of Electronic Publication: 2021 Jun 06.

Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors.

Autor: Chetter BA; School of Physical Sciences & Computing, University of Central Lancashire, Preston PR1 2HE, United Kingdom., Kyriakis E; Department of Biochemistry & Biotechnology, University of Thessaly, Biopolis, 41500 Larissa, Greece., Barr D; School of Physical Sciences & Computing, University of Central Lancashire, Preston PR1 2HE, United Kingdom., Karra AG; Department of Biochemistry & Biotechnology, University of Thessaly, Biopolis, 41500 Larissa, Greece., Katsidou E; Department of Biochemistry & Biotechnology, University of Thessaly, Biopolis, 41500 Larissa, Greece., Koulas SM; Department of Biochemistry & Biotechnology, University of Thessaly, Biopolis, 41500 Larissa, Greece., Skamnaki VT; Department of Biochemistry & Biotechnology, University of Thessaly, Biopolis, 41500 Larissa, Greece., Snape TJ; School of Pharmacy & Biomedical Sciences, University of Central Lancashire, Preston PR1 2HE, United Kingdom. Electronic address: tjsnape@uclan.ac.uk., Psarra AG; Department of Biochemistry & Biotechnology, University of Thessaly, Biopolis, 41500 Larissa, Greece. Electronic address: ampsarra@bio.uth.gr., Leonidas DD; Department of Biochemistry & Biotechnology, University of Thessaly, Biopolis, 41500 Larissa, Greece. Electronic address: ddleonidas@bio.uth.gr., Hayes JM; School of Pharmacy & Biomedical Sciences, University of Central Lancashire, Preston PR1 2HE, United Kingdom. Electronic address: jhayes@uclan.ac.uk.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2020 Sep; Vol. 102, pp. 104003. Date of Electronic Publication: 2020 Jun 10.