Zobrazeno 1 - 10
of 1 482
pro vyhledávání: '"Snap25"'
Publikováno v:
FEBS Open Bio, Vol 14, Iss 11, Pp 1864-1872 (2024)
SNAP25 plays an essential role in the glucose‐stimulated insulin secretion (GSIS) of pancreatic β‐cells. Carbohydrate response element‐binding protein (ChREBP) is an important transcription factor in β‐cells and, in this study, we aimed to
Externí odkaz:
https://doaj.org/article/cc5e687ea1ac43ba97b26fb00930f915
Autor:
Adlin Abramian, Rein I Hoogstraaten, Fiona H Murphy, Kathryn F McDaniel, Ruud F Toonen, Matthijs Verhage
Publikováno v:
eLife, Vol 13 (2024)
Neuropeptides and neurotrophins are stored in and released from dense core vesicles (DCVs). While DCVs and synaptic vesicles (SVs) share fundamental SNARE/SM proteins for exocytosis, a detailed understanding of DCV exocytosis remains elusive. We rece
Externí odkaz:
https://doaj.org/article/8df4ba1466d64e7c88f641f81fa7540e
Autor:
Wen-Qi Wu, Kai Li, Lu-Lu Chu, Ting-Ting Shen, Yang Li, Ying-Ying Xu, Qi-Lin Zhang, Chun-Feng Liu, Jing Liu, Xu-Ping Zhou, Wei-Feng Luo
Publikováno v:
Heliyon, Vol 10, Iss 8, Pp e28543- (2024)
Objective: Individual differences were observed in the clinical efficacy of Botulinum toxin A (BoNT-A) in the treatment of the primary Meige syndrome. Our study aimed to explore the potential associations between the clinical efficacy of BoNT-A in th
Externí odkaz:
https://doaj.org/article/7cccc79a87e643a391d2b447ffdc6d37
Autor:
Martina Maria Mensi, Franca Rosa Guerini, Michele Marchesi, Matteo Chiappedi, Elisabetta Bolognesi, Renato Borgatti
Publikováno v:
Pediatric Reports, Vol 15, Iss 4, Pp 766-773 (2023)
While there is substantial agreement on the diagnostic criteria for autism spectrum disorder, it is also acknowledged that it has a broad range of clinical presentations. This can complicate the diagnostic process and aggravate the choice of the most
Externí odkaz:
https://doaj.org/article/443147ce21b7468e8fadb21de15bc554
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract Background Synaptosomal-associated protein 25 (SNAP25) exerts protective effects against postoperative cognitive dysfunction (POCD) by promoting PTEN-induced kinase 1 (PINK1)/Parkin-mediated mitophagy and repressing caspase-3/gasdermin E (GS
Externí odkaz:
https://doaj.org/article/d3ec6a8d0f8f4870b00007de55481d7b
Autor:
Qian Wang, Sijue Tao, Lei Xing, Jiuyu Liu, Cankun Xu, Xinyi Xu, Haohan Ding, Qi Shen, Xiaobo Yu, Yingwei Zheng
Publikováno v:
European Journal of Medical Research, Vol 28, Iss 1, Pp 1-13 (2023)
Abstract Background Alzheimer’s disease (AD) and Parkinson’s disease (PD), two common irreversible neurodegenerative diseases, share similar early stage syndromes, such as olfaction dysfunction. Yet, the potential comorbidity mechanism of AD and
Externí odkaz:
https://doaj.org/article/8ddafc0f212b407292b539ddd10cd0e5
Autor:
Daniela Felício, Andreia Dias, Sandra Martins, Estefânia Carvalho, Alexandra M. Lopes, Nádia Pinto, Carolina Lemos, Mariana Santos, Miguel Alves-Ferreira
Publikováno v:
The Journal of Headache and Pain, Vol 24, Iss 1, Pp 1-7 (2023)
Abstract Migraine is a common and complex neurological disease potentially caused by a polygenic interaction of multiple gene variants. Many genes associated with migraine are involved in pathways controlling the synaptic function and neurotransmitte
Externí odkaz:
https://doaj.org/article/99d01bb37c1441798b159c5e6deff1eb
Autor:
Vincent Martin, Denis Carre, Heloise Bilbault, Sebastien Oster, Lorenzo Limana, Florian Sebal, Christine Favre-Guilmard, Mikhail Kalinichev, Christian Leveque, Virginie Boulifard, Catherine George, Stephane Lezmi
Publikováno v:
Toxins, Vol 16, Iss 5, p 225 (2024)
Botulinum neurotoxins E (BoNT/E) and A (BoNT/A) act by cleaving Synaptosome-Associated Protein 25 (SNAP25) at two different C-terminal sites, but they display very distinct durations of action, BoNT/E being short acting and BoNT/A long acting. We inv
Externí odkaz:
https://doaj.org/article/da39eda0c3fa4bd69e626c7a3f507400
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