Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Snahel Patel"'
Autor:
Francis Grafton, Jaclyn Ho, Sara Ranjbarvaziri, Farshad Farshidfar, Anastasiia Budan, Stephanie Steltzer, Mahnaz Maddah, Kevin E Loewke, Kristina Green, Snahel Patel, Tim Hoey, Mohammad Ali Mandegar
Publikováno v:
eLife, Vol 10 (2021)
Drug-induced cardiotoxicity and hepatotoxicity are major causes of drug attrition. To decrease late-stage drug attrition, pharmaceutical and biotechnology industries need to establish biologically relevant models that use phenotypic screening to dete
Externí odkaz:
https://doaj.org/article/ac40721906f04a0b8947457bd4ad3670
Autor:
Jin Yang, Francis Grafton, Sara Ranjbarvaziri, Ana Budan, Farshad Farshidfar, Marie Cho, Emma Xu, Jaclyn Ho, Mahnaz Maddah, Kevin E. Loewke, Julio Medina, David Sperandio, Snahel Patel, Tim Hoey, Mohammad A. Mandegar
Publikováno v:
Science translational medicine. 14(652)
Dilated cardiomyopathy (DCM) is characterized by reduced cardiac output, as well as thinning and enlargement of left ventricular chambers. These characteristics eventually lead to heart failure. Current standards of care do not target the underlying
Autor:
Snahel Patel, Barun Bhhatarai, Philamer Calses, Daniel Erlanson, Robert Everley, Susan Fong, Phil Gerken, Johannes C. Hermann, Tiep Le, Li-kai Liu, Evan McMahon, Richard M. Neve, Tony Phan, Allison Roberts, Mikayla Shanafelt, Sophie Siemsgluess, Jocelyn Staunton, Yan Wang, Weiru Wang, Monika Williams, Kevin R. Webster
Publikováno v:
Cancer Research. 83:1142-1142
KRAS is one of the most frequently mutated genes in cancer and was long considered undruggable until the recent discovery of inhibitors that bind the inactive (GDP-bound) form of KRASG12C. The most clinically advanced of these first-generation molecu
Autor:
Domagoj Vucic, Jonathan Maher, Tatiana Goncharov, Hua Zhang, Nina Ljumanovic, Brent S. McKenzie, Joshua D. Webster, Nick Corr, Youngsu Kwon, Sara F Santagostino, Summer Park, Snahel Patel, Eugene Varfolomeev, Jessica Preston, Adeyemi O Adedeji, Min Xu
Publikováno v:
Journal of Leukocyte Biology
Receptor interacting protein kinase 1 (RIP1) is a critical effector of inflammatory responses and cell death activation. Cell death pathways regulated by RIP1 include caspase‐dependent apoptosis and caspase‐independent necroptosis. The kinase act
Autor:
Shumei Wang, Jodie Pang, Heidi J.A. Wallweber, Leah Schutt, Michael Siu, Steven T. Staben, Christopher J. Sneeringer, Yunli Wang, Aditya Murthy, Dennis X. Hu, Yoana N. Dimitrova, Madeleine S. Prangley, Grace Ka Yan Chan, Erin McNamara, Laurent Salphati, Haochu Huang, Huifen Chen, Yong Chen, Snahel Patel, Kai C. Wu, Wensheng Zhao, John Moffat, Junghyun Lim, Joanna Y. Lee
Publikováno v:
Journal of medicinal chemistry. 65(17)
VPS34 is a class III phosphoinositide 3-kinase involved in endosomal trafficking and autophagosome formation. Inhibitors of VPS34 were believed to have value as anticancer agents, but genetic and pharmacological data suggest that sustained inhibition
Autor:
Zhaowu Xu, Charles Eigenbrot, Patrick J. Lupardus, Rina Fong, Jing Wang, Huifen Chen, Gauri Deshmukh, Gregory Hamilton, Snahel Patel, Haowei Wang, Domagoj Vucic, Yunliang Zhu, Pawan Bir Kohli, Adam R. Johnson, Bianca M. Liederer, Sreemathy Ramaswamy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1497-1501
Receptor-interacting protein kinase 1 (RIPK1), a key component of the cellular necroptosis pathway, has gained recognition as an important therapeutic target. Pharmacologic inhibition or genetic inactivation of RIPK1 has shown promise in animal model
Autor:
Patrick Caplazi, P. Bir Kohli, Joshua D. Webster, M. van Lookeren Campagne, Allie Maltzman, Gregory Hamilton, Wyne P. Lee, Evgeny Varfolomeev, Rina Fong, Brent S. McKenzie, Melissa R. Junttila, Swathi Sujatha-Bhaskar, Juan Zhang, Katherine E. Wickliffe, Patrick J. Lupardus, Debra L. Dugger, Domagoj Vucic, Snahel Patel, J.H. Cheng, Bianca M. Liederer, Kim Newton, Youngsu Kwon, Sreemathy Ramaswamy, Adam R. Johnson, Gauri Deshmukh
Publikováno v:
Cell Death and Differentiation
The kinase RIP1 acts in multiple signaling pathways to regulate inflammatory responses and it can trigger both apoptosis and necroptosis. Its kinase activity has been implicated in a range of inflammatory, neurodegenerative, and oncogenic diseases. H
Autor:
Philamer Calses, Sam Clark, Jacob Corpuz, Susan Fong, Phil Gerkin, Mohammad Hekmatnejad, Evan McMahon, Megan Murray, Truc Nguyen, Tony Phan, Allison Roberts, Phillip Schwartz, Mikayla Shanafelt, Hiroko Tanaka, Jennifer Tomczyk, John Widen, Monika Williams, John Eksterowicz, Daniel Erlanson, Marie Evangelista, Johannes Hermann, Richard M. Neve, Snahel Patel, Kevin R. Webster
Publikováno v:
Cancer Research. 82:3601-3601
KRAS is one of the most frequently mutated genes in cancer with alterations occurring in > 14% of all tumors. Recent advances have led to the discovery and development of inhibitors that bind the inactive (GDP-bound) form of KRASG12C. The most advanc
Autor:
Yichin Liu, Peter S. Dragovich, Daniel F. Ortwine, Birong Zhang, Richard D. Cummings, Jun Liang, Yingqing Ran, Marie Classon, Sharada Labadie, Tommy Lai, Weifeng Mao, Victor S. Gehling, Bianca M. Liederer, Erica Van der Porten, Jean-Christophe Harmange, Till Mauer, Le An, Xiaoping Zheng, Jiangpeng Liao, James R. Kiefer, Maia Vinogradova, Snahel Patel, Patrick Trojer, Gauri Deshmukh, Amy Gustafson, Lesley J. Murray
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2974-2981
A high-throughput screening (HTS) of the Genentech/Roche library identified a novel, uncharged scaffold as a KDM5A inhibitor. Lacking insight into the binding mode, initial attempts to improve inhibitor potency failed to improve potency, and synthesi
Autor:
Amy Gustafson, Michael Siu, Reina N. Fuji, Anthony A. Estrada, Jinhua Chen, Jianping Yin, Gauri Deshmukh, Yichin Liu, Seth F. Harris, Jose Imperio, Rebecca Erickson, William J. Meilandt, Changyou Ma, Snahel Patel, Joseph P. Lyssikatos, Paul Gibbons, Wendy Liu, Xingrong Liu, Joseph W. Lewcock
Publikováno v:
Journal of medicinal chemistry. 60(19)
Significant data exists to suggest that dual leucine zipper kinase (DLK, MAP3K12) is a conserved regulator of neuronal degeneration following neuronal injury and in chronic neurodegenerative disease. Consequently, there is considerable interest in th