Bitiscetin-3, a Novel C-Type Lectin-like Protein Cloned from the Venom Gland of the Viper Bitis arietans, Induces Platelet Agglutination and Inhibits Binding of Von Willebrand Factor to Collagen

Autor: Youhei Nashimoto, Fumio Matsushita, Johannes M. Dijkstra, Yuta Nakamura, Hidehiko Akiyama, Jiharu Hamako, Takashi Morita, Satohiko Araki, Taei Matsui

Publikováno v: Toxins; Volume 14; Issue 4; Pages: 236

Bitiscetin-1 (aka bitiscetin) and bitiscetin-2 are C-type lectin-like proteins purified from the venom of Bitis arietans (puff adder). They bind to von Willebrand factor (VWF) and—at least bitiscetin-1—induce platelet agglutination via enhancemen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d584439c22abfe5cb7991cb2f567bbb9

Macrovipecetin, a C-type lectin from Macrovipera lebetina venom, inhibits proliferation migration and invasion of SK-MEL-28 human melanoma cells and enhances their sensitivity to cisplatin

Autor: Habib Karoui, Kenneth J. Clemetson, Timothy N. C. Wells, Houcemeddine Othman, Soumaya Souid, José Neptuno Rodríguez-López, Ichrak Riahi-Chebbi, Zohra Aloui, Ammar Gasmi, Edith M. Magnenat, Najet Srairi-Abid, Khadija Essafi-Benkhadir, Manel B Hammouda

Publikováno v: Biochimica et Biophysica Acta (BBA)-General Subjects
Biochimica et Biophysica Acta (BBA)-General Subjects, Elsevier, 2018, 1862 (3), pp.600--614. ⟨10.1016/j.bbagen.2017.11.019⟩

Background The resistance of melanoma cells to cisplatin restricts its clinical use. Therefore, the search for novel tumor inhibitors and effective combination treatments that sensitize tumor cells to this drug are still needed. We purified macrovipe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f1c617f4ea3f5dfa760615b6a3fee6
https://doi.org/10.1016/j.bbagen.2017.11.019

Rhinocetin, a Venom-derived Integrin-specific Antagonist Inhibits Collagen-induced Platelet and Endothelial Cell Functions

Autor: Jonathan M. Gibbins, E. Gail Hutchinson, Andrew B. Bicknell, Ronald G. Stanley, Abeer Dannoura, Marfoua S. Ali, Sakthivel Vaiyapuri, Robert A. Harrison

Publikováno v: The Journal of Biological Chemistry

Background: Snaclecs affect the hemostasis of snakebite victims upon envenomation. Results: Rhinocetin, a novel snaclec, inhibits integrin α2β1-dependent functions of human platelets and endothelial cells. Conclusion: The actions of rhinocetin are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c06f42002677f32fc6a6c31fda5f2f96
https://doi.org/10.1074/jbc.m112.381483

Systemic effects induced by the venom of the snake Bothrops caribbaeus in a murine model

Autor: José María Gutiérrez, Cristina Herrera, Alexandra Rucavado, David A. Warrell

Publikováno v: Toxicon; Volume 63. 2013
Kérwá
Universidad de Costa Rica
instacron:UCR

Snakebite envenoming by Bothrops caribbaeus, an endemic viperid from the Lesser Antillean island of Saint Lucia, is clinically characterized by local tissue damage and systemic thrombosis that can lead to cerebral, myocardial or pulmonary infarctions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f5bfe5b53b61d8522492f52a6d30134
http://ora.ox.ac.uk/objects/uuid:9bd6425f-b7b4-440d-91c6-4b749f716d66

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