Výsledky vyhledávání - "Smythies, James A"

Akademický článek

Decorin causes autophagy in endothelial cells via Peg3

Autor: Buraschi, Simone, Neill, Thomas, Goyal, Atul, Poluzzi, Chiara, Smythies, James, Owens, Rick T., Schaefer, Liliana, Torres, Annabel, Iozzo, Renato V.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2013 Jul 01. 110(28), 11223-11223.

Externí odkaz: https://www.jstor.org/stable/42712707

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Akademický článek

Endorepellin Affects Angiogenesis by Antagonizing Diverse Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)-evoked Signaling Pathways: TRANSCRIPTIONAL REPRESSION OF HYPOXIA-INDUCIBLE FACTOR 1α AND VEGFA AND CONCURRENT INHIBITION OF NUCLEAR FACTOR OF ACTIVATED T CELL 1 (NFAT1) ACTIVATION

Autor: Goyal, Atul, Poluzzi, Chiara, Willis, Chris D., Smythies, James, Shellard, Adam, Neill, Thomas, Iozzo, Renato V.

Publikováno v: In Journal of Biological Chemistry 21 December 2012 287(52):43543-43556

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Inherent DNA-binding specificities of the HIF-1α and HIF-2α transcription factors in chromatin

Autor: Smythies, James A, Sun, Min, Masson, Norma, Salama, Rafik, Simpson, Peter D, Murray, Elizabeth, Neumann, Viviana, Cockman, Matthew E, Choudhry, Hani, Ratcliffe, Peter J, Mole, David R

Hypoxia-inducible factor (HIF) is the major transcriptional regulator of cellular responses to hypoxia. The two principal HIF-α isoforms, HIF-1α and HIF-2α, are progressively stabilized in response to hypoxia and form heterodimers with HIF-1β to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c339991aabca355fb43f2d0e490c21

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Inherent DNA‐binding specificities of the HIF‐1α and HIF‐2α transcription factors in chromatin

Autor: Smythies, James A, Sun, Min, Masson, Norma, Salama, Rafik, Simpson, Peter D, Murray, Elizabeth, Neumann, Viviana, Cockman, Matthew E, Choudhry, Hani, Ratcliffe, Peter J, Mole, David R

Publikováno v: EMBO Reports

Hypoxia‐inducible factor (HIF) is the major transcriptional regulator of cellular responses to hypoxia. The two principal HIF‐α isoforms, HIF‐1α and HIF‐2α, are progressively stabilized in response to hypoxia and form heterodimers with HIF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b9344378e92d5af639241bd8ce39dd3e
http://europepmc.org/articles/PMC6322389

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Akademický článek

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Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway

Autor: Grampp, Steffen, Schmid, Virginia, Salama, Rafik, Lauer, Victoria, Kranz, Franziska, Platt, James L., Smythies, James, Choudhry, Hani, Goppelt-Struebe, Margarete, Ratcliffe, Peter J., Mole, David R., Schödel, Johannes

Publikováno v: PLoS Genetics, Vol 13, Iss 7, p e1006872 (2017)
PLoS Genetics

Un-physiological activation of hypoxia inducible factor (HIF) is an early event in most renal cell cancers (RCC) following inactivation of the von Hippel-Lindau tumor suppressor. Despite intense study, how this impinges on cancer development is incom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c2970cdcf0097fc9384a1f2eb204be7b
http://europepmc.org/articles/PMC5536434?pdf=render

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Dissertation/ Thesis

Characterising the determinants of hypoxia inducible transcription factors binding to chromatin

Autor: Smythies, James

Hypoxia regulates many hundreds of genes that play important roles in numerous physiological and pathophysiological processes. The hypoxia inducible transcription factors (HIFs) are central to the transcriptional activation of these hypoxia-regulated

Externí odkaz: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.748704

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