Zobrazeno 1 - 10
of 377
pro vyhledávání: '"Smyth Paul"'
Fine-tuning Protein Language Models with Deep Mutational Scanning improves Variant Effect Prediction
Autor:
Lafita, Aleix, Gonzalez, Ferran, Hossam, Mahmoud, Smyth, Paul, Deasy, Jacob, Allyn-Feuer, Ari, Seaton, Daniel, Young, Stephen
Protein Language Models (PLMs) have emerged as performant and scalable tools for predicting the functional impact and clinical significance of protein-coding variants, but they still lag experimental accuracy. Here, we present a novel fine-tuning app
Externí odkaz:
http://arxiv.org/abs/2405.06729
We present an application of the well-known Mask R-CNN approach to the counting of different types of bacterial colony forming units that were cultured in Petri dishes. Our model was made available to lab technicians in a modern SPA (Single-Page Appl
Externí odkaz:
http://arxiv.org/abs/2103.05337
During the development of vaccines, bacterial colony forming units (CFUs) are counted in order to quantify the yield in the fermentation process. This manual task is time-consuming and error-prone. In this work we test multiple segmentation algorithm
Externí odkaz:
http://arxiv.org/abs/2009.00926
Autor:
Gallagher Michael F, Heffron Cynthia CBB, Laios Alexandros, O'Toole Sharon A, Ffrench Brendan, Smyth Paul C, Flavin Richard J, Elbaruni Salah A, Spillane Cathy D, Martin Cara M, Sheils Orla M, O'Leary John J
Publikováno v:
Journal of Ovarian Research, Vol 5, Iss 1, p 2 (2012)
Abstract Background Malignant ovarian disease is characterised by high rates of mortality due to high rates of recurrent chemoresistant disease. Anecdotal evidence indicates this may be due to chemoresistant properties of cancer stem cells (CSCs). Ho
Externí odkaz:
https://doaj.org/article/25684533327049feab4c31d487d25546
Autor:
Gallagher Michael F, Flavin Richard J, Elbaruni Salah A, McInerney Jamie K, Smyth Paul C, Salley Yvonne M, Vencken Sebastian F, O'Toole Sharon A, Laios Alexandros, Lee Mathia YC, Denning Karen, Li Jinghuan, Aherne Sinead T, Lao Kai Q, Martin Cara M, Sheils Orla M, O'Leary John J
Publikováno v:
Journal of Ovarian Research, Vol 2, Iss 1, p 19 (2009)
Abstract Background Tumours with high proportions of differentiated cells are considered to be of a lower grade to those containing high proportions of undifferentiated cells. This property may be linked to the differentiation properties of stem cell
Externí odkaz:
https://doaj.org/article/94d9c4f9b4a74aa886b21e5182b624fd
Autor:
Li Jing, Denning Karen M, Russell Susan M, Flavin Richard J, Smyth Paul C, Aherne Sinéad T, Guenther Simone M, O'Leary John J, Sheils Orla M
Publikováno v:
Molecular Cancer, Vol 7, Iss 1, p 89 (2008)
Abstract Background Papillary thyroid carcinoma (PTC) frequently presents as multiple tumour-foci within a single thyroid gland or pluriform, with synchronous tumours comprising different histological variants, raising questions regarding its clonali
Externí odkaz:
https://doaj.org/article/980f6cd24a16437ebc92a08021584c0c
Autor:
Aherne Sinead, Flavin Richard, Li Jinghuan, Cahill Susanne, Smyth Paul, Denning Karen, O' Leary John J, Sheils Orla
Publikováno v:
Molecular Cancer, Vol 7, Iss 1, p 44 (2008)
Abstract Background Hashimoto Thyroiditis (H.T.) is a destructive autoimmune thyroid condition whose precise molecular pathogenesis remains unclear. ret/PTC-1 is a chimeric transcript which has been described in autoimmune thyroid disease (AITD) and
Externí odkaz:
https://doaj.org/article/e88b1c9f20954413951ad3165fdafe4a
Autor:
Pirotta Marco, Aherne Sinead, Flavin Richard, Denning Karen, Cahill Susanne, Smyth Paul, Li Jinghuan, Guenther Simone M, O'Leary John J, Sheils Orla
Publikováno v:
BMC Biotechnology, Vol 8, Iss 1, p 10 (2008)
Abstract Background Archival formalin-fixed paraffin-embedded (FFPE) tissues represent an abundant source of clinical specimens; however their use is limited in applications involving analysis of gene expression due to RNA degradation and modificatio
Externí odkaz:
https://doaj.org/article/9579d75747114fd19206bd752a0aefd4
Autor:
Guenther Simone M, Aherne Sinead, Denning Karen, Cahill Susanne, Flavin Richard, Smyth Paul, Li Jinghuan, O'Leary John J, Sheils Orla
Publikováno v:
BMC Biotechnology, Vol 7, Iss 1, p 36 (2007)
Abstract Background Archival formalin-fixed paraffin-embedded (FFPE) tissues have limited utility in applications involving analysis of gene expression due to mRNA degradation and modification during fixation and processing. This study analyzed 160 m
Externí odkaz:
https://doaj.org/article/a8be3fabb105440ba533771476de5f34