Zobrazeno 1 - 10
of 436
pro vyhledávání: '"Smyd3"'
Autor:
Paola Sanese, Katia De Marco, Martina Lepore Signorile, Francesca La Rocca, Giovanna Forte, Marialaura Latrofa, Candida Fasano, Vittoria Disciglio, Elisabetta Di Nicola, Antonino Pantaleo, Giusy Bianco, Vito Spilotro, Claudia Ferroni, Matilde Tubertini, Nicoletta Labarile, Lucia De Marinis, Raffaele Armentano, Gianluigi Gigante, Valerio Lantone, Giuliano Lantone, Marina Naldi, Manuela Bartolini, Greta Varchi, Alberto Del Rio, Valentina Grossi, Cristiano Simone
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-23 (2024)
Abstract Background SMYD3 has been found implicated in cancer progression. Its overexpression correlates with cancer growth and invasion, especially in gastrointestinal tumors. SMYD3 transactivates multiple oncogenic mechanisms, favoring cancer devel
Externí odkaz:
https://doaj.org/article/8a2633f1acb94d078dc7358f99a7585f
Autor:
Qian Ding, Jianghong Cai, Li Jin, Wei Hu, Wu Song, Peter Rose, Zhiyuan Tang, Yangyang Zhan, Leilei Bao, Wei Lei, Yi Zhun Zhu
Publikováno v:
MedComm, Vol 5, Iss 10, Pp n/a-n/a (2024)
Abstract SMYD3 (SET and MYND domain‐containing 3) is a histone lysine methyltransferase highly expressed in different types of cancer(s) and is a promising epigenetic target for developing novel antitumor therapeutics. No selective inhibitors for t
Externí odkaz:
https://doaj.org/article/725b52e331dd4676b9332e5ec258277a
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous and common upper airway disease divided into various inflammatory endotypes. Recent epidemiological findings showed a T helper 2 (Th2)-skewed dominance in CRSwNP patients.
Externí odkaz:
https://doaj.org/article/39695be8ee7e47fd86eac9901aef5437
Autor:
Candida Fasano, Martina Lepore Signorile, Elisabetta Di Nicola, Antonino Pantaleo, Giovanna Forte, Katia De Marco, Paola Sanese, Vittoria Disciglio, Valentina Grossi, Cristiano Simone
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 5240-5248 (2023)
SMDY3 is a histone-lysine N-methyltransferase involved in several oncogenic processes and is believed to play a major role in various cancer hallmarks. Recently, we identified ATM, BRCA2, CHK2, MTOR, BLM, MET, AMPK, and p130 as direct SMYD3 interacto
Externí odkaz:
https://doaj.org/article/bd4d1a6d0f7846eab0639bd64810a285
Publikováno v:
Journal of Hepatocellular Carcinoma, Vol Volume 10, Pp 1237-1256 (2023)
Jin Sun,1– 3 Yingnan Li,1– 3 Mengjiao Shi,1,2 Hongwei Tian,1– 3 Jun Li,1– 3 Kai Zhu,1– 3 Ying Guo,1– 3 Yanhua Mu,1– 3 Jing Geng,1– 3 Zongfang Li1– 4 1National-Local Joint Engineering Research Center of Biodiagnostics and Biotherapy,
Externí odkaz:
https://doaj.org/article/2d699d2c70e244fab3b0c0a05050d4ed
Autor:
Zongcheng Yang, Fen Liu, Zongkai Li, Nianping Liu, Xinfeng Yao, Yu Zhou, Liyu Zhang, Pan Jiang, Honghong Liu, Lingming Kong, Chuandong Lang, Xin Xu, Jihui Jia, Takahito Nakajima, Wenchao Gu, Lixin Zheng, Zhihong Zhang
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-21 (2023)
Abstract Background Epigenetic dysregulation is essential to the tumorigenesis of oral squamous cell carcinoma (OSCC). SET and MYND domain-containing protein 3 (SMYD3), a histone lysine methyltransferase, is implicated in gene transcription regulatio
Externí odkaz:
https://doaj.org/article/48165d1b5ffe41a9a40201e2b429ff83
Akademický článek
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Publikováno v:
Jichu yixue yu linchuang, Vol 43, Iss 1, Pp 68-75 (2023)
Objective The study focuses on the prognostic value of SMYD3 in pan cancer, and analyze the influence of SMYD3 on tumor tissue immune infiltration. Methods The gene expression and protein density data were collected from TCGA, GTEx and HPA databases.
Externí odkaz:
https://doaj.org/article/4af962bda743446185299921845505bc
Autor:
Yang Yang, Rongfang Qiu, Siyu Zhao, Lin Shen, Bufu Tang, Qiaoyou Weng, Ziwei Xu, Liyun Zheng, Weiqian Chen, Gaofeng Shu, Yajie Wang, Zhongwei Zhao, Minjiang Chen, Jiansong Ji
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-22 (2022)
Abstract Background SMYD3, a member of the SET and MYND domain-containing (SMYD) family, is a histone methyltransferase (HMT) and transcription factor that plays an important role in transcriptional regulation in human carcinogenesis. Results Using a
Externí odkaz:
https://doaj.org/article/62f5e8407d5a4566a9e30ff436b7e69f
Autor:
Ewud Agborbesong, Julie Xia Zhou, Hongbing Zhang, Linda Xiaoyan Li, Peter C. Harris, James P. Calvet, Xiaogang Li
Publikováno v:
Biomedicines, Vol 12, Iss 3, p 603 (2024)
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder worldwide and progresses to end-stage renal disease (ESRD). However, its precise mechanism is not fully understood. In recent years, epigenetic reprogra
Externí odkaz:
https://doaj.org/article/5c55ec817551433eaf550eaa1e543d53