Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Smriti Sangwan"'
Autor:
Smriti Sangwan, Shruti Sahay, Kevin A Murray, Sophie Morgan, Elizabeth L Guenther, Lin Jiang, Christopher K Williams, Harry V Vinters, Michel Goedert, David S Eisenberg
Publikováno v:
eLife, Vol 9 (2020)
Seeding, in the context of amyloid disease, is the sequential transfer of pathogenic protein aggregates from cell-to-cell within affected tissues. The structure of pathogenic seeds provides the molecular basis and enables rapid conversion of soluble
Externí odkaz:
https://doaj.org/article/28a8e57e2eee4c3c8246bb0a5890354f
Autor:
Rosalie E Lawrence, Sophie Shoemaker, Aniliese Deal, Smriti Sangwan, Aditya Anand, Lan Wang, Susan Marqusee, Peter Walter
The Integrated Stress Response (ISR) enables cells to survive a variety of acute stresses, but chronic activation of the ISR underlies age-related diseases. ISR signaling down-regulates translation and activates expression of stress-responsive factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d70f42c7d1bf9d31d23e5d480b3eec5
https://doi.org/10.1101/2022.12.22.521453
https://doi.org/10.1101/2022.12.22.521453
Autor:
Advait Subramanian, Lan Wang, Tom Moss, Mark Voorhies, Smriti Sangwan, Erica Stevenson, Ernst H. Pulido, Samentha Kwok, Nevan J. Krogan, Danielle L. Swaney, Stephen N. Floor, Anita Sil, Peter Walter, Shaeri Mukherjee
Pathogens often secrete proteins or nucleic acids that mimic the structure and/or function of molecules expressed in their hosts. Molecular mimicry empowers pathogens to subvert critical host processes and establish infection. We report that the intr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8aa2760bc66d1b64f85d393e167606b6
https://doi.org/10.1101/2022.06.10.495705
https://doi.org/10.1101/2022.06.10.495705
Autor:
Un Seng Chio, Ming Sun, Adolfo García-Sastre, R.A. Saunders, Niv Dobzinski, Jiahao Liang, Vladislav Belyy, Peter Walter, Caleigh M. Azumaya, Beth S. Zha, Fei Li, Morgane Boone, Kris M. White, Yuwei Liu, Kaitlin Schaefer, Frank R. Moss, Aashish Manglik, Nevan J. Krogan, Michael C. Thompson, Nick Hoppe, Alexandrea N. Rizo, Axel F. Brilot, Danielle L. Swaney, S. Dickinson, Corie Y. Ralston, Bryan Faust, Devan Diwanji, A.W. Barile-Hill, Camille R. Simoneau, Smriti Sangwan, Sayan Gupta, Benjamin Barsi-Rhyne, Mingliang Jin, Veronica V. Rezelj, Huong T. Kratochvil, Silke Nock, David Bulkley, Kristoffer E. Leon, Marco Vignuzzi, Sergei Pourmal, Henry C. Nguyen, Thomas H. Pospiech, Gregory E. Merz, Raphael Trenker, Cynthia M. Chio, Yanxin Liu, Kaihua Zhang, Meghna Gupta, Aditya A. Anand, Cristina Puchades, M. Zimanyi, Amber M. Smith, Michael Schoof, Christian B. Billesbølle, Melanie Ott, Ishan Deshpande
Publikováno v:
Science (New York, N.y.)
Science
Science
Nanobodies that neutralize Monoclonal antibodies that bind to the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) show therapeutic promise but must be produced in mammalian cells and need to be delivered intravenously. B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c74ff65944a0933cee2079cf142211
https://pubmed.ncbi.nlm.nih.gov/32817938
https://pubmed.ncbi.nlm.nih.gov/32817938
Autor:
Henry C. Nguyen, Devan Diwanji, Smriti Sangwan, Sayan Gupta, Niv Dobzinski, Michael C. Thompson, M. Zimanyi, Rezelj, Marco Vignuzzi, Camille R. Simoneau, Corie Y. Ralston, Cristina Puchades, Thomas H. Pospiech, Beth S. Zha, Kaihua Zhang, Jiahao Liang, Sergei Pourmal, Axel F. Brilot, David Bulkley, Fei Li, Danielle L. Swaney, Nick Hoppe, A.W. Barile-Hill, Amber M. Smith, Raphael Trenker, Melanie Ott, Un Seng Chio, Gregory E. Merz, Ishan Deshpande, Alexandrea N. Rizo, Peter Walter, Kris M. White, R.A. Saunders, Ming Sun, Aditya A. Anand, Morgane Boone, Adolfo García-Sastre, Cynthia M. Chio, Yanxin Liu, Kaitlin Schaefer, Aashish Manglik, Nevan J. Krogan, Frank R. Moss, S. Dickinson, Huong T. Kratochvil, Caleigh M. Azumaya, Silke Nock, Mingliang Jin, Kristoffer E. Leon, Belyy, Meghna Gupta, Michael Schoof, Christian B. Billesbølle, Bryan Faust, Benjamin Barsi-Rhyne
Publikováno v:
bioRxiv
Without an effective prophylactic solution, infections from SARS-CoV-2 continue to rise worldwide with devastating health and economic costs. SARS-CoV-2 gains entry into host cells via an interaction between its Spike protein and the host cell recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f1f208dd04d4d89775155b81ed47fe
https://doi.org/10.1101/2020.08.08.238469
https://doi.org/10.1101/2020.08.08.238469
Autor:
Shruti Sahay, Michel Goedert, Harry V. Vinters, Christopher Williams, Kevin A. Murray, E.L. Guenther, Smriti Sangwan, Lin Jiang, David Eisenberg, Sophie A. Morgan
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Seeding, in the context of amyloid disease, is the sequential transfer of pathogenic protein aggregates from cell-to-cell within affected tissues. The structure of pathogenic seeds provides the molecular basis and enables rapid conversion of soluble
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b823e50ecf853458d29a71bce99a5236
https://escholarship.org/uc/item/7mq2t05x
https://escholarship.org/uc/item/7mq2t05x
Publikováno v:
Protein Science. 27:1231-1242
The aggregation cascade of disease‐related amyloidogenic proteins, terminating in insoluble amyloid fibrils, involves intermediate oligomeric states. The structural and biochemical details of these oligomers have been largely unknown. Here we repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe97993144d9076fa9d6eaae05f7475c
https://doi.org/10.1002/pro.3391
https://doi.org/10.1002/pro.3391
Autor:
Sophie A. Morgan, Kevin A. Murray, Smriti Sangwan, Lin Jiang, E.L. Guenther, Shruti Sahay, Christopher Williams, Harry V. Vinters, David Eisenberg, Michel Goedert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdd94e55413e4c924545d3d028e0c0b8
https://doi.org/10.7554/elife.46775.sa2
https://doi.org/10.7554/elife.46775.sa2
Autor:
Smriti Sangwan, David S Eisenberg
Publikováno v:
Postępy Biochemii. 62:362-369
A myotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive degeneration of spinal motor neurons. Although mutations in dozens of proteins have been associated with ALS, the enzyme, superoxide dismutase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6adb15f2bf0f0ab7852700ed68c9f38c
https://doi.org/10.18388/pb.2016_37
https://doi.org/10.18388/pb.2016_37
Publikováno v:
The Journal of Physical Chemistry B. 120:5810-5816
Structural studies of amyloidogenic segments by X-ray crystallography have revealed a novel packing motif, consisting of out-of-register β sheets, which may constitute one of the toxic species in aggregation related diseases. Here we sought to deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b38f173617916c6aaa089fda0fc77a7
https://doi.org/10.1021/acs.jpcb.5b09981
https://doi.org/10.1021/acs.jpcb.5b09981