Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Smriti Khera"'
Autor:
Mark Anderson Jordi, Nina Chen, Syed Lateef, Paige Solomon, James Woods, Liuwei Jiang, Kevin Roland, Frankie Aiello, Samantha Martin, Jenny Nelson, Leland Martin, Smriti Khera
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 150
The advent of single-use bioprocess systems used for the delivery, storage or manufacture of biopharmaceuticals has introduced a new potential source for extractables and leachables (E&L) as these systems are comprised of polymeric materials. Several
Autor:
Smriti Khera, Na Hu
Publikováno v:
Analytical and Bioanalytical Chemistry. 405:6009-6018
The generation of key drug metabolites for the purpose of their complete structural characterization, toxicity testing, as well as to serve as standards for quantitative studies, is a critical step in the pharmaceutical discovery and development cycl
Publikováno v:
Drug Metabolism and Disposition. 41:111-121
Ibuprofen is metabolized to chemically reactive acyl glucuronide and S-acyl-CoA metabolites that are proposed to transacylate glutathione (GSH) forming ibuprofen-S-acyl-GSH (I-SG) in vivo. Herein, we report the detection of novel metabolites of ibupr
Publikováno v:
Journal of Chemical Ecology. 33:1149-1159
The viceroy-monarch and viceroy-queen butterfly associations are classic examples of mimicry. These relationships were originally classified as Batesian, or parasitic, but were later reclassified as Müllerian, or mutalistic, based on predator bioass
Publikováno v:
Journal of Natural Products. 66:1628-1631
Bioassay-guided fractionation of the antibacterial CH(2)Cl(2)-MeOH extract obtained from the aerial parts of the Argentinean plant Caiophora coronata led to the isolation of a new triterpene, 1beta,3beta-dihydroxyurs-12-en-27-oic acid, 1, and a new i
Publikováno v:
Acta Crystallographica Section C Crystal Structure Communications. 60:o773-o775
The structure of an iridolactone isolated from Valeriana laxiflora was established as (4R,4aR,6S,7S,7aS)-6-hydroxy-7-hydroxymethyl-4-methylperhydrocyclopenta[c]pyran-1-one chloroform solvate, C(10)H(16)O(4).CHCl(3). The two rings are cis-fused. The d
Flunoxaprofen (FLX) is a chiral nonsteroidal anti-inflammatory drug that was withdrawn from clinical use because of concerns of potential hepatotoxicity. FLX undergoes highly stereoselective chiral inversion mediated through the FLX-S-acyl-CoA thioes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09133fc0f400011101115555f4644cd
https://europepmc.org/articles/PMC2802421/
https://europepmc.org/articles/PMC2802421/
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 51(1)
Diffusion-edited NMR spectroscopy is used to enable the structural characterization of low level metabolites in the presence of endogenous compounds, and organic solvents. We compared data from standard one-dimensional (1D) 1 H, 1D NOESY-presaturatio
Publikováno v:
ChemInform. 36
The structure of the title compound was determined in the Molecular Structure Laboratory of the Department of Chemistry, University of Arizona. The diffractometer was obtained with funds provided by the NSF (grant No. CHE9610374). This study was supp
Publikováno v:
Acta Crystallographica Section E Structure Reports Online. 59:o1403-o1404
This structure was determined in the Molecular Structure Laboratory of the Department of Chemistry, University of Arizona, Tucson, AZ 85721, USA. The SMART1000 diffractometer was gratefully obtained with funds provided by NSF grant CHE9610374. This s