Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Smriti, Joseph"'
Autor:
Smriti Joseph, Janan Jona, Jason Brooks Human, Leyla Arik, Gondi N. Kumar, Toshihiro Aya, Randall W. Hungate, Jian J. Chen, Kaustav Biswas, Tanya Peterkin, Jiawang Zhu, Zufan Wu, Wenyuan Qian, Hong-Xun Guo, Eileen Johnson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1061-1067
In a series of bradykinin B1 antagonists, we discovered that replacement of oxopiperazine acetamides with dehydro-oxopiperazine acetamides provided compounds with enhanced activity against the B1 receptor. The synthesis and SAR leading to potent anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ebdb6efcda7e8ebe5c15c876f3b315d
https://doi.org/10.1016/j.bmcl.2011.11.112
https://doi.org/10.1016/j.bmcl.2011.11.112
Autor:
Clarence Hale, Martin Henriksson, Randall W. Hungate, Renee Komorowski, Kyung H. Gahm, Jiandong Zhang, Murielle M. Véniant, Janan Jona, Vivian S. W. Li, Andrew Hague, Maurice Emery, Christopher H. Fotsch, Steven R. Jordan, Smriti Joseph, David J. St. Jean, Lars Johansson, Minghan Wang, Rashid Syed, Jeffrey Adams, George A. Moniz, Rod Cupples, Ki Won Kim, Michael D. Bartberger, Jerk Vallgarda, Michelle Chen, Meredith Williams
Publikováno v:
Journal of Medicinal Chemistry. 53:4481-4487
Thiazolones with an exo-norbornylamine at the 2-position and an isopropyl group on the 5-position are potent 11beta-HSD1 inhibitors. However, the C-5 center was prone to epimerization in vitro and in vivo, forming a less potent diastereomer. A methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe379e52733a44c74ee775e8c1cbc9ee
https://doi.org/10.1021/jm100242d
https://doi.org/10.1021/jm100242d
Autor:
Yan Gu, Paul E. Rose, John L. Buchanan, Satin Sawant, Jean-Christophe Harmange, Chun Li, Evelyn Yanez, Janan Jona, Rod Cupples, Smriti Joseph, Rakesh Kumar, Brett E. Houk, H. Toni Jun, Stuart C. Chaffee, Tom Menges, Kathy Hodge, Huilin Zhao, Susan M. Turci, Xiaotian Zhu, Michael Morrison, Robert Radinsky, Lilly Chai, Paul Gallant, David P. Carney, Sekhar Surapaneni, Ji-Rong Sun, Keyang Xu, John Newcomb, Linda F. Epstein, Xin Huang, John Lu, Perry M. Novak, Simon Van Der Plas
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(8)
The insulin-like growth factor-1 receptor (IGF-1R) plays an important role in the regulation of cell growth and differentiation, and in protection from apoptosis. IGF-1R has been shown to be an appealing target for the treatment of human cancer. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763457c616d771983818c519c788d656
https://pubmed.ncbi.nlm.nih.gov/21414779
https://pubmed.ncbi.nlm.nih.gov/21414779
Autor:
Murielle M, Véniant, Clarence, Hale, Randall W, Hungate, Kyung, Gahm, Maurice G, Emery, Janan, Jona, Smriti, Joseph, Jeffrey, Adams, Andrew, Hague, George, Moniz, Jiandong, Zhang, Michael D, Bartberger, Vivian, Li, Rashid, Syed, Steven, Jordan, Renée, Komorowski, Michelle M, Chen, Rod, Cupples, Ki Won, Kim, David J, St Jean, Lars, Johansson, Martin A, Henriksson, Meredith, Williams, Jerk, Vallgårda, Christopher, Fotsch, Minghan, Wang
Publikováno v:
Journal of medicinal chemistry. 53(11)
Thiazolones with an exo-norbornylamine at the 2-position and an isopropyl group on the 5-position are potent 11beta-HSD1 inhibitors. However, the C-5 center was prone to epimerization in vitro and in vivo, forming a less potent diastereomer. A methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::13bcf7f3326234b742459daf061c837f
https://pubmed.ncbi.nlm.nih.gov/20465278
https://pubmed.ncbi.nlm.nih.gov/20465278