Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Smrita Sinha"'
Autor:
Pankaj J. Pasricha, Steven D. Leach, David Tuveson, Robert C. Kurtz, Young Park, Lindsey Baker, Olca Basturk, In-Hong Yang, Olivera Grbovic-Huezo, Min Geol Joo, Yi Zhong, Jerry P. Melchor, Jennifer M. Bailey, Gokce Askan, Joseph A. Saglimbeni, Kelly Lafaro, Maren Ketcham, Adrien Grimont, Ya-Yuan Fu, Smrita Sinha
3D animation showing innervation of a PanIN lesion.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e765b9f3143e66bd1d292ce25c4c73
https://doi.org/10.1158/0008-5472.22417332
https://doi.org/10.1158/0008-5472.22417332
Autor:
Pankaj J. Pasricha, Steven D. Leach, David Tuveson, Robert C. Kurtz, Young Park, Lindsey Baker, Olca Basturk, In-Hong Yang, Olivera Grbovic-Huezo, Min Geol Joo, Yi Zhong, Jerry P. Melchor, Jennifer M. Bailey, Gokce Askan, Joseph A. Saglimbeni, Kelly Lafaro, Maren Ketcham, Adrien Grimont, Ya-Yuan Fu, Smrita Sinha
List of target genes and their respective primer sequences used in qPCR analyses.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e410a64575dbd4a25869313e5cc8203
https://doi.org/10.1158/0008-5472.22417338.v1
https://doi.org/10.1158/0008-5472.22417338.v1
Autor:
Pankaj J. Pasricha, Steven D. Leach, David Tuveson, Robert C. Kurtz, Young Park, Lindsey Baker, Olca Basturk, In-Hong Yang, Olivera Grbovic-Huezo, Min Geol Joo, Yi Zhong, Jerry P. Melchor, Jennifer M. Bailey, Gokce Askan, Joseph A. Saglimbeni, Kelly Lafaro, Maren Ketcham, Adrien Grimont, Ya-Yuan Fu, Smrita Sinha
Bright field and fluorescent live imaging of NK1-Rlow (red) and NK1-Rhi/GFP (yellow) cells plated together in organoid culture.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3249665908953478b5dc37bb325efb75
https://doi.org/10.1158/0008-5472.22417329.v1
https://doi.org/10.1158/0008-5472.22417329.v1
Autor:
Pankaj J. Pasricha, Steven D. Leach, David Tuveson, Robert C. Kurtz, Young Park, Lindsey Baker, Olca Basturk, In-Hong Yang, Olivera Grbovic-Huezo, Min Geol Joo, Yi Zhong, Jerry P. Melchor, Jennifer M. Bailey, Gokce Askan, Joseph A. Saglimbeni, Kelly Lafaro, Maren Ketcham, Adrien Grimont, Ya-Yuan Fu, Smrita Sinha
Supplementary Materials and Methods section provides additional data on the protocols used in this manuscript including those pertaining to chemical and reagents, denervation, flow cytometry and sorting, immunohistochemistry and immunofluorescence, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::022c1e331f598da72048da2761ea1e08
https://doi.org/10.1158/0008-5472.22417335
https://doi.org/10.1158/0008-5472.22417335
Autor:
Pankaj J. Pasricha, Steven D. Leach, David Tuveson, Robert C. Kurtz, Young Park, Lindsey Baker, Olca Basturk, In-Hong Yang, Olivera Grbovic-Huezo, Min Geol Joo, Yi Zhong, Jerry P. Melchor, Jennifer M. Bailey, Gokce Askan, Joseph A. Saglimbeni, Kelly Lafaro, Maren Ketcham, Adrien Grimont, Ya-Yuan Fu, Smrita Sinha
Contains the figure legends for supplemental Figures S1-S8, Table S1 and Videos V1 and V2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::178ae0bb2d706331febd426b67ec125f
https://doi.org/10.1158/0008-5472.22417344
https://doi.org/10.1158/0008-5472.22417344
Autor:
Pankaj J. Pasricha, Steven D. Leach, David Tuveson, Robert C. Kurtz, Young Park, Lindsey Baker, Olca Basturk, In-Hong Yang, Olivera Grbovic-Huezo, Min Geol Joo, Yi Zhong, Jerry P. Melchor, Jennifer M. Bailey, Gokce Askan, Joseph A. Saglimbeni, Kelly Lafaro, Maren Ketcham, Adrien Grimont, Ya-Yuan Fu, Smrita Sinha
Nerves are a notable feature of the tumor microenvironment in some epithelial tumors, but their role in the malignant progression of pancreatic ductal adenocarcinoma (PDAC) is uncertain. Here, we identify dense innervation in the microenvironment of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127eff590c312af109b8ad91d9001f6e
https://doi.org/10.1158/0008-5472.c.6509814.v1
https://doi.org/10.1158/0008-5472.c.6509814.v1
Autor:
H. Chintalapudi, Smrita Sinha, Christine A. Iacobuzio-Donahue, Jonathan Bermeo, V. Aveson, Richard A. Moffitt, A. Cardenas, Lance Zhang, S. Laderman, Vinod P. Balachandran, Kenneth H. Yu, Danielle C. Glassman, Rohit Chandwani, Nicolas Lecomte, D. Torres, Christina S. Leslie, Steven D. Leach, B. Curry, Gokce Askan, Jerry P. Melchor, S. Leppanen, A. L. Massa, Sagar Chhangawala, Jiang Gui, Surajit Dhara, Alvin Makohon-Moore, Rémy Nicolle
We investigated tumor-cell-intrinsic chromatin accessibility patterns of pancreatic ductal adenocarcinoma (PDAC) by ATAC-seq on EpCAM+ PDAC malignant epithelial cells, sorted from 54 freshly resected human tumors, and discovered a signature of 1092 c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4a9239cf47239cc8efaa23399acc80b
https://doi.org/10.1101/2021.01.21.427604
https://doi.org/10.1101/2021.01.21.427604
Autor:
Christina S. Leslie, A. Cardenas, S. Leppanen, Rohit Chandwani, Lance Zhang, Smrita Sinha, S. Laderman, Danielle C. Glassman, Sagar Chhangawala, V. Aveson, Nicolas Lecomte, Steven D. Leach, D. Torres, Vinod P. Balachandran, Jiang Gui, Surajit Dhara, Richard A. Moffitt, Kenneth H. Yu, Alvin Makohon-Moore, B. Curry, Gokce Askan, Rémy Nicolle, H. Chintalapudi, Christine A. Iacobuzio-Donahue, A. L. Massa, Jonathan Bermeo, Jerry P. Melchor
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Unlike other malignancies, therapeutic options in pancreatic ductal adenocarcinoma (PDAC) are largely limited to cytotoxic chemotherapy without the benefit of molecular markers predicting response. Here we report tumor-cell-intrinsic chromatin access
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a83add7cde624ad24db43f48b5d954d
https://pubmed.ncbi.nlm.nih.gov/34031415
https://pubmed.ncbi.nlm.nih.gov/34031415
Autor:
Gokce Askan, Robert C. Kurtz, In Hong Yang, Yi Zhong, Olca Basturk, Olivera Grbovic-Huezo, Jerry P. Melchor, Min Geol Joo, Joseph Saglimbeni, Ya-Yuan Fu, Kelly J. Lafaro, Steven D. Leach, Jennifer M. Bailey, Pankaj J. Pasricha, Adrien Grimont, Maren Ketcham, David A. Tuveson, Lindsey A. Baker, Young-Kyu Park, Smrita Sinha
Publikováno v:
Cancer Research. 77:1868-1879
Nerves are a notable feature of the tumor microenvironment in some epithelial tumors, but their role in the malignant progression of pancreatic ductal adenocarcinoma (PDAC) is uncertain. Here, we identify dense innervation in the microenvironment of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb99533c4d79d0d6e497a9c775e42aa0
https://doi.org/10.1158/0008-5472.can-16-0899-t
https://doi.org/10.1158/0008-5472.can-16-0899-t
Autor:
Smrita Sinha, Steven D. Leach
Publikováno v:
Current Opinion in Gastroenterology. 32:394-400
Purpose of review The review intends to describe recent studies on the development of pancreatic cancer from a genetic, molecular, and microenvironment perspective. Recent findings Pancreatic cancer has been discovered to have distinct molecular subt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcd8f562cb36985d9ae663bc12e2938a
https://doi.org/10.1097/mog.0000000000000295
https://doi.org/10.1097/mog.0000000000000295