Diagnostic yield and clinical impact of germline sequencing in children with CNS and extracranial solid tumors-a nationwide, prospective Swedish study.

Autor: Tesi B; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Clinical Genetics and Genomics, Karolinska University Hospital, Solna, Sweden.; Department of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Stockholm, Sweden., Robinson KL; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Clinical Genetics and Genomics, Karolinska University Hospital, Solna, Sweden., Abel F; Department of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden.; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Díaz de Ståhl T; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.; Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden., Orrsjö S; Department of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden.; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Poluha A; Clinical Genetics, Uppsala University Hospital, Uppsala, Sweden.; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden., Hellberg M; Department of Clinical Genetics, Pathology and Molecular Diagnostics, Office of Medical Services, Region Skåne, Lund, Sweden., Wessman S; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.; Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden., Samuelsson S; Department of Clinical Genetics, Pathology and Molecular Diagnostics, Office of Medical Services, Region Skåne, Lund, Sweden., Frisk T; Department of Pediatric Hematology and Oncology, Karolinska University Hospital, Stockholm, Sweden.; Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden., Vogt H; Crown Princess Victoria Children's Hospital, and Division of Children's and Women's Health, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Henning K; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Department of Pediatric Hematology and Oncology, Karolinska University Hospital, Stockholm, Sweden., Sabel M; Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden.; Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden., Ek T; Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden.; Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden., Pal N; Department of Pediatric Hematology and Oncology, Karolinska University Hospital, Stockholm, Sweden., Nyman P; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.; Centre for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden., Giraud G; Department of Immunology, Genetics, and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.; Pediatric Oncology, Uppsala University Children's Hospital, Uppsala, Sweden.; Department of Women's and Children's Health, Uppsala University, Sweden., Wille J; Childhood Cancer Center, Skåne University Hospital, Lund, Sweden., Pronk CJ; Childhood Cancer Center, Skåne University Hospital, Lund, Sweden.; Division of Molecular Hematology/Wallenberg Center for Molecular Medicine, Lund University, Sweden., Norén-Nyström U; Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden., Borssén M; Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden., Fili M; Division of Eye and Vision, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; St. Erik Eye Hospital, Stockholm, Sweden., Stålhammar G; Division of Eye and Vision, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; St. Erik Eye Hospital, Stockholm, Sweden., Herold N; Department of Pediatric Hematology and Oncology, Karolinska University Hospital, Stockholm, Sweden.; Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden., Tettamanti G; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Unit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Maya-Gonzalez C; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Arvidsson L; Department of Clinical Genetics, Pathology and Molecular Diagnostics, Office of Medical Services, Region Skåne, Lund, Sweden., Rosén A; Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden., Ekholm K; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Clinical Genetics and Genomics, Karolinska University Hospital, Solna, Sweden., Kuchinskaya E; Department of Clinical Genetics, Linköping University Hospital, Linköping, Sweden., Hallbeck AL; Department of Clinical Genetics, Linköping University Hospital, Linköping, Sweden.; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Nordling M; Department of Clinical Genetics, Linköping University Hospital, Linköping, Sweden.; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Palmebäck P; Department of Clinical Genetics, Linköping University Hospital, Linköping, Sweden., Kogner P; Department of Pediatric Hematology and Oncology, Karolinska University Hospital, Stockholm, Sweden.; Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden., Smoler GK; Department of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden., Lähteenmäki P; Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden., Fransson S; Department of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden.; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Martinsson T; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Shamik A; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.; Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden., Mertens F; Department of Clinical Genetics, Pathology and Molecular Diagnostics, Office of Medical Services, Region Skåne, Lund, Sweden., Rosenquist R; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Clinical Genetics and Genomics, Karolinska University Hospital, Solna, Sweden.; Genomic Medicine Center Karolinska, Karolinska University Hospital, Stockholm, Sweden., Wirta V; Genomic Medicine Center Karolinska, Karolinska University Hospital, Stockholm, Sweden.; Science for Life Laboratory, Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet, Stockholm, Sweden.; Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institutet of Technology, Stockholm, Sweden., Tham E; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Clinical Genetics and Genomics, Karolinska University Hospital, Solna, Sweden., Grillner P; Department of Pediatric Hematology and Oncology, Karolinska University Hospital, Stockholm, Sweden.; Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden., Sandgren J; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.; Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden., Ljungman G; Pediatric Oncology, Uppsala University Children's Hospital, Uppsala, Sweden.; Department of Women's and Children's Health, Uppsala University, Sweden., Gisselsson D; Department of Clinical Genetics, Pathology and Molecular Diagnostics, Office of Medical Services, Region Skåne, Lund, Sweden., Taylan F; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Clinical Genetics and Genomics, Karolinska University Hospital, Solna, Sweden., Nordgren A; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Clinical Genetics and Genomics, Karolinska University Hospital, Solna, Sweden.; Department of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden.; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Genomic Medicine Center Karolinska, Karolinska University Hospital, Stockholm, Sweden.

Publikováno v: The Lancet regional health. Europe [Lancet Reg Health Eur] 2024 Mar 19; Vol. 39, pp. 100881. Date of Electronic Publication: 2024 Mar 19 (Print Publication: 2024).