Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Smitha Yerrum"'
Autor:
Jonathan So, Nathaniel W. Mabe, Bernhard Englinger, Kin-Hoe Chow, Sydney M. Moyer, Smitha Yerrum, Maria C. Trissal, Joana G. Marques, Jason J. Kwon, Brian Shim, Sangita Pal, Eshini Panditharatna, Thomas Quinn, Daniel A. Schaefer, Daeun Jeong, David L. Mayhew, Justin Hwang, Rameen Beroukhim, Keith L. Ligon, Kimberly Stegmaier, Mariella G. Filbin, William C. Hahn
Publikováno v:
JCI Insight, Vol 7, Iss 19 (2022)
Collateral lethality occurs when loss of a gene/protein renders cancer cells dependent on its remaining paralog. Combining genome-scale CRISPR/Cas9 loss-of-function screens with RNA sequencing in over 900 cancer cell lines, we found that cancers of n
Externí odkaz:
https://doaj.org/article/701d31e0fcdd484e84a5da699c9787f9
E2 suppressed the expression of PPARγ target gene ACOX3 in three breast cancer cell lines. MCF-7 cells were transferred from phenol red containing medium to E2-free medium for 3 days. Next, (A) MCF-7, (B) MCF-7:5C, and (C) MCF-7:2A cells were seeded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9524b311dc06c10efdcf3c93fd811105
https://doi.org/10.1158/1535-7163.22504924
https://doi.org/10.1158/1535-7163.22504924
Peroxisome proliferator-activated receptor γ (PPARγ) is an important transcription factor that modulates lipid metabolism and inflammation. However, it remains unclear whether PPARγ is involved in modulation of estrogen (E2)-induced inflammation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a53781abf15866a92eac6abdfe19be3
https://doi.org/10.1158/1535-7163.c.6537895.v1
https://doi.org/10.1158/1535-7163.c.6537895.v1
Autor:
V. Craig Jordan, Nae J. Dun, Eric R. Prossnitz, Tudor I. Oprea, Jeffrey B. Arterburn, Anne L. Donato, Michael A. Black, Heather E. Cunliffe, Michael J. Slifker, Heather A. Shupp, Smitha Yerrum, Eugen Brailoiu, Eric A. Ariazi
Supplementary Figure 1 from The G Protein–Coupled Receptor GPR30 Inhibits Proliferation of Estrogen Receptor–Positive Breast Cancer Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ffbce276b8352f022b19cd9b0322dd
https://doi.org/10.1158/0008-5472.22387254.v1
https://doi.org/10.1158/0008-5472.22387254.v1
Autor:
V. Craig Jordan, Nae J. Dun, Eric R. Prossnitz, Tudor I. Oprea, Jeffrey B. Arterburn, Anne L. Donato, Michael A. Black, Heather E. Cunliffe, Michael J. Slifker, Heather A. Shupp, Smitha Yerrum, Eugen Brailoiu, Eric A. Ariazi
Supplementary Methods from The G Protein–Coupled Receptor GPR30 Inhibits Proliferation of Estrogen Receptor–Positive Breast Cancer Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19a8f40cf723971791e40813a381ee4f
https://doi.org/10.1158/0008-5472.22387251
https://doi.org/10.1158/0008-5472.22387251
Autor:
Xiaoqing Wang, Raga Vadhi, Pei-Lun Kao, Alok K. Tewari, Kin-Hoe Chow, Renee C. Geck, Aliya Jaber, X. Shirley Liu, Alba Font-Tello, Tengfei Xiao, Paloma Cejas, Klothilda Lim, Hui Liu, Xintao Qiu, Murry Morrow, Henry W. Long, Yingtian Xie, Smitha Yerrum, Yihao Li, Quang-Dé Nguyen, Alex Toker, Myles Brown, Kristen L Jones
Publikováno v:
Nature Cell Biology. 23:1187-1198
How cancer cells adapt to evade the therapeutic effects of drugs targeting oncogenic drivers is poorly understood. Here we report an epigenetic mechanism leading to the adaptive resistance of triple-negative breast cancer (TNBC) to fibroblast growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0b0cc97e1f22bdd7194609ae2da950b
https://doi.org/10.1038/s41556-021-00781-z
https://doi.org/10.1038/s41556-021-00781-z
Autor:
Smitha Yerrum, Ping Fan, Fadeke A. Agboke, Doris R. Siwak, Balkees Abderrahman, V. Craig Jordan
Publikováno v:
Molecular Cancer Therapeutics. 18:1684-1695
Our clinically relevant finding is that glucocorticoids block estrogen (E(2))-induced apoptosis in long-term E(2)-deprived (LTED) breast cancer cells. However, the mechanism remains unclear. Here, we demonstrated that E(2) widely activated adipose in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1709caa83c85544aad7a8358b784f840
https://doi.org/10.1158/1535-7163.mct-18-1363
https://doi.org/10.1158/1535-7163.mct-18-1363
Autor:
Paloma Cejas, Renee C. Geck, Aliya Jaber, J. L. Kristen, Myles Brown, Smitha Yerrum, Hui Liu, Tengfei Xiao, Kin-Hoe Chow, Yingtian Xie, Raga Vadhi, Pei-Lun Kao, Alok K. Tewari, Henry W. Long, Xiaoqing Wang, Quang-Dé Nguyen, Xiaole Shirley Liu, Kah-Leong Lim, M. Morrow, Li Y, Alex Toker, Alba Font-Tello, Xintao Qiu
How cancer cells adapt to evade the therapeutic effects of drugs targeting oncogenic drivers is poorly understood. Here we report an epigenetic mechanism leading to the adaptive resistance of triple-negative breast cancer (TNBC) to fibroblast growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2fe82ef006c86e4a87c3e7ab85c7f33
https://doi.org/10.1101/2021.03.02.433446
https://doi.org/10.1101/2021.03.02.433446
Autor:
Smitha Yerrum, Wenya Linda Bi, Michael Y. Tolstorukov, David Meredith, Sandro Santagata, Kin-Hoe Chow, Claire Sinai, Yu Zeng, Nan Lin, Aniket Shetty, Sigitas Verselis, Tony Tran, Jean J. Zhao, Patrick Y. Wen, Zach Herbert, Ayal A. Aizer, Keith L. Ligon, William Pisano, Eudocia Q. Lee, Lakshmi Nayak, E. Antonio Chiocca, Kristine Pelton, Rileen Sinha, Pei-Lun Kao, Aliya Jaber, Dylan E Freitas, David M. Weinstock, Ugonma Chukwueke
Publikováno v:
Neuro Oncol
Brain metastases (BM) are a leading cause of cancer death and prognosis remains poor despite treatment advances at other sites. Models are central to therapeutic development, but few orthotopic patient-derived xenograft (PDX) models of BM exist. To r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05149f0cfc38cdd7e46df707c2a157f0
https://europepmc.org/articles/PMC7651178/
https://europepmc.org/articles/PMC7651178/
Autor:
Yu Zeng, Tony Tran, Keith L. Ligon, Rileen Sinha, Pei-Lun Kao, Timothy R. Smith, Aniket Shetty, Lakshmi Nayak, Ugonma Chukwueke, David Meredith, Wenya Linda Bi, Michael Y. Tolstorukov, Kin-Hoe Chow, Omar Arnaout, Smitha Yerrum
Publikováno v:
Neuro Oncol
Lymphomas of the central nervous system (CNSL) are rare tumors with few treatment options; however, recent genomic studies have uncovered several druggable targets. To facilitate novel treatment discovery, we sought to establish patient-derived xenog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c099600361624c46fbd16751a2cafaea
https://doi.org/10.1093/neuonc/noaa215.984
https://doi.org/10.1093/neuonc/noaa215.984