Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Smitha Sreedharan"'
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Akademický článek
The polyamine transporter Slc18b1(VPAT) is important for both short and long time memory and for regulation of polyamine content in the brain.
Autor: Robert Fredriksson, Smitha Sreedharan, Karin Nordenankar, Johan Alsiö, Frida A Lindberg, Ashley Hutchinson, Anders Eriksson, Sahar Roshanbin, Diana M Ciuculete, Anica Klockars, Aniruddha Todkar, Maria G Hägglund, Sofie V Hellsten, Viktoria Hindlycke, Åke Västermark, Ganna Shevchenko, Gaia Olivo, Cheng K, Klas Kullander, Ali Moazzami, Jonas Bergquist, Pawel K Olszewski, Helgi B Schiöth
Publikováno v: PLoS Genetics, Vol 15, Iss 12, p e1008455 (2019)
SLC18B1 is a sister gene to the vesicular monoamine and acetylcholine transporters, and the only known polyamine transporter, with unknown physiological role. We reveal that Slc18b1 knock out mice has significantly reduced polyamine content in the br
Externí odkaz: https://doaj.org/article/c6784a73fd584b62a4be350dc823a3d6
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2
Akademický článek
The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes
Autor: Yuan Xie, Tobias Bergström, Yiwen Jiang, Patrik Johansson, Voichita Dana Marinescu, Nanna Lindberg, Anna Segerman, Grzegorz Wicher, Mia Niklasson, Sathishkumar Baskaran, Smitha Sreedharan, Isabelle Everlien, Marianne Kastemar, Annika Hermansson, Lioudmila Elfineh, Sylwia Libard, Eric Charles Holland, Göran Hesselager, Irina Alafuzoff, Bengt Westermark, Sven Nelander, Karin Forsberg-Nilsson, Lene Uhrbom
Publikováno v: EBioMedicine, Vol 2, Iss 10, Pp 1351-1363 (2015)
Glioblastoma (GBM) is the most frequent and malignant form of primary brain tumor. GBM is essentially incurable and its resistance to therapy is attributed to a subpopulation of cells called glioma stem cells (GSCs). To meet the present shortage of r
Externí odkaz: https://doaj.org/article/75556f6c5fd94fbea5d121e6ecd740bb
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7
Mouse Models of Pediatric Supratentorial High-grade Glioma Reveal How Cell-of-Origin Influences Tumor Development and Phenotype
Autor: Malin Jarvius, Sylwia Libard, Lene Uhrbom, Anders Sundström, Yuan Xie, Mårten Fryknäs, Fredrik J. Swartling, Irina Alafuzoff, Holger Weishaupt, Naga Prathyusha Maturi, Smitha Sreedharan, Rolf Larsson
Publikováno v: Cancer Research. 77:802-812
High-grade glioma (HGG) is a group of primary malignant brain tumors with dismal prognosis. Whereas adult HGG has been studied extensively, childhood HGG, a relatively rare disease, is less well-characterized. Here, we present two novel platelet-deri
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d9dc853e25db7c22bebd811ed81796
https://doi.org/10.1158/0008-5472.can-16-2482
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8
Multimodal Eph/Ephrin signaling controls several phases of urogenital development
Autor: Derek C. Adams, Klas Kullander, Leif Oxburgh, Rüdiger Klein, Christiane Peuckert, Pavlo Holenya, Smitha Sreedharan, Bejan Aresh, Annika Porthin, Louise Andersson, Stefan Wölfl, H. Pettersson
Publikováno v: Kidney International. 90:373-388
A substantial portion of the human population is affected by urogenital birth defects resulting from a failure in ureter development. Although recent research suggests roles for several genes in facilitating the ureter/bladder connection, the underly
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc103a223538a62679caa5eeeff3d28
https://doi.org/10.1016/j.kint.2016.04.021
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9
Transport of l-Glutamine, l-Alanine, l-Arginine and l-Histidine by the Neuron-Specific Slc38a8 (SNAT8) in CNS
Autor: Edvin Karlsson, Victor C. O. Nilsson, Smitha Sreedharan, Sonchita Bagchi, Atieh Tafreshiha, Sofie V. Hellsten, Gaëtan Philippot, Robert Fredriksson, Erik Löfqvist, Ingrid Almkvist, Maria Hägglund
Publikováno v: Journal of Molecular Biology. 427:1495-1512
Glutamine transporters are important for regulating levels of glutamate and GABA in the brain. To date, six members of the SLC38 family (SNATs) have been characterized and functionally subdivided them into System A (SNAT1, SNAT2 and SNAT4) and System
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51a4f68879f124887e4e1b1085f55c40
https://doi.org/10.1016/j.jmb.2014.10.016
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10
The G protein coupled receptor Gpr153 shares common evolutionary origin with Gpr162 and is highly expressed in central regions including the thalamus, cerebellum and the arcuate nucleus
Autor: Susan R de Barioglio, Valeria P. Carlini, Tatjana Haitina, Olga Stephansson, Robert Fredriksson, Markus Sällman Almén, Wolfgang H. Sommer, M. Heilig, Helgi B. Schiöth, Smitha Sreedharan
Publikováno v: FEBS Journal. 278:4881-4894
Transmembrane proteins are gatekeepers of the cells; controlling the transport of substrates as well as communicating signals among cells and between the organelles and cytosol. Solute carriers (SLC) and G protein-coupled receptors (GPCR) are the lar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f598b9e433eade9aad82eb988272412
https://doi.org/10.1111/j.1742-4658.2011.08388.x
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