Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Smitha Antony"'
Autor:
Jiamo Lu, Guojian Jiang, Yongzhong Wu, Smitha Antony, Jennifer L Meitzler, Agnes Juhasz, Han Liu, Krishnendu Roy, Hala Makhlouf, Rodrigo Chuaqui, Donna Butcher, Mariam M Konaté, James H Doroshow
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233208 (2020)
To facilitate functional investigation of the role of NADPH oxidase 1 (NOX1) and associated reactive oxygen species in cancer cell signaling, we report herein the development and characterization of a novel mouse monoclonal antibody that specifically
Externí odkaz:
https://doaj.org/article/ebb8d7dabc614df08b60c032e03783fa
Autor:
Jennifer L. Meitzler, Hala R. Makhlouf, Smitha Antony, Yongzhong Wu, Donna Butcher, Guojian Jiang, Agnes Juhasz, Jiamo Lu, Iris Dahan, Pidder Jansen-Dürr, Haymo Pircher, Ajay M. Shah, Krishnendu Roy, James H. Doroshow
Publikováno v:
Redox Biology, Vol 13, Iss C, Pp 182-195 (2017)
NADPH oxidase 4 (NOX4) is a redox active, membrane-associated protein that contributes to genomic instability, redox signaling, and radiation sensitivity in human cancers based on its capacity to generate H2O2 constitutively. Most studies of NOX4 in
Externí odkaz:
https://doaj.org/article/203b8e09d2b54f679af386b93069e9e0
Autor:
Yves Pommier, Mark Cushman, Andrew Morrell, Muthukaman Nagarajan, Lyuba Varticovski, Ana I. Robles, Mollie H. Wright, Kazutaka Takagi, Ze-Hong Miao, Keli K. Agama, Smitha Antony
Supplementary Figure 1 from Novel Indenoisoquinolines NSC 725776 and NSC 724998 Produce Persistent Topoisomerase I Cleavage Complexes and Overcome Multidrug Resistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2055b6e4c927bba8f9bd53f8d257249
https://doi.org/10.1158/0008-5472.22370723
https://doi.org/10.1158/0008-5472.22370723
Autor:
Yves Pommier, Mark Cushman, Andrew Morrell, Muthukaman Nagarajan, Lyuba Varticovski, Ana I. Robles, Mollie H. Wright, Kazutaka Takagi, Ze-Hong Miao, Keli K. Agama, Smitha Antony
Supplementary Legends 1-2 from Novel Indenoisoquinolines NSC 725776 and NSC 724998 Produce Persistent Topoisomerase I Cleavage Complexes and Overcome Multidrug Resistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb34828216563fb3e16c2c830f2fd0b
https://doi.org/10.1158/0008-5472.22370714.v1
https://doi.org/10.1158/0008-5472.22370714.v1
Autor:
Yves Pommier, Mark Cushman, Andrew Morrell, Muthukaman Nagarajan, Lyuba Varticovski, Ana I. Robles, Mollie H. Wright, Kazutaka Takagi, Ze-Hong Miao, Keli K. Agama, Smitha Antony
Supplementary Figure 2 from Novel Indenoisoquinolines NSC 725776 and NSC 724998 Produce Persistent Topoisomerase I Cleavage Complexes and Overcome Multidrug Resistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0e9487e8173d3ab78a45adcc63a1d4
https://doi.org/10.1158/0008-5472.22370717.v1
https://doi.org/10.1158/0008-5472.22370717.v1
Autor:
Yves Pommier, Mark Cushman, Andrew Morrell, Muthukaman Nagarajan, Lyuba Varticovski, Ana I. Robles, Mollie H. Wright, Kazutaka Takagi, Ze-Hong Miao, Keli K. Agama, Smitha Antony
Camptothecin (CPT) derivatives are effective anticancer drugs, especially against solid tumors. As CPTs are chemically unstable and have clinical limitations, we have synthesized indenoisoquinolines as novel topoisomerase I (Top1) inhibitors. We pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::381ff7da4f951f0811fb86bb6f789f58
https://doi.org/10.1158/0008-5472.c.6496505.v1
https://doi.org/10.1158/0008-5472.c.6496505.v1
Autor:
Stephen L. Wang, Yongzhong Wu, Mariam Konaté, Jiamo Lu, Smitha Antony, Jennifer L. Meitzler, Guojian Jiang, Iris Dahan, Agnes Juhasz, Becky Diebold, Krishnendu Roy, James H. Doroshow
Pro-inflammatory cytokines upregulate the expression of the H2O2-producing NADPH oxidase dual oxidase 2 (DUOX2) which, when elevated, adversely affects survival from pancreatic ductal adenocarcinoma (PDAC). Because the cGAS-STING pathway is known to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37a11980f34b5d4752ab40266d9a41f7
https://doi.org/10.1101/2022.05.14.491678
https://doi.org/10.1101/2022.05.14.491678
Autor:
David J. Mallick, Yongzhong Wu, Mariam M. Konaté, Becky A. Diebold, Smitha Antony, Jennifer L. Meitzler, Guojian Jiang, Jiamo Lu, Krishnendu Roy, James H. Doroshow
Publikováno v:
Cancer Research. 82:1318-1318
Pancreatic inflammation contributes to increased risk of pancreatic adenocarcinoma (PDAC) development through the release of pro-inflammatory cytokines and generation of reactive oxygen species (ROS). Interleukin-1 (IL-1) is a major upstream pro-infl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a9f49f2124683ae1635474497afd2c3
https://doi.org/10.1158/1538-7445.am2022-1318
https://doi.org/10.1158/1538-7445.am2022-1318
Publikováno v:
Antioxid Redox Signal
Significance: The primary function of NADPH oxidases (NOX1–5 and dual oxidases DUOX1/2) is to produce reactive oxygen species (ROS). If inadequately regulated, NOX-associated ROS can promote oxidative stress, aberrant signaling, and genomic instabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c402d5c911564e5625073871974e6d
https://doi.org/10.1089/ars.2020.8046
https://doi.org/10.1089/ars.2020.8046
Autor:
Yongzhong Wu, Mariam M. Konaté, Melinda Hollingshead, Baktiar Karim, Becky Diebold, Jiamo Lu, Smitha Antony, Jennifer L. Meitzler, Agnes Juhasz, Guojian Jiang, Iris Dahan, Krishnendu Roy, James H. Doroshow
Previously, we demonstrated that pro-inflammatory cytokines enhance dual oxidase 2 (DUOX2)-dependent production of reactive oxygen species by human pancreatic ductal carcinoma (PDAC) cells, and that DUOX2 expression is significantly increased in pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc3c770f5621f8774991ca4e6177720b
https://doi.org/10.1101/2022.02.13.480277
https://doi.org/10.1101/2022.02.13.480277