Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Smith Yvonne Dorothy"'
Autor:
Katy Bridgwood, Catherine R. Kostlan, Matthew Carroll, Danielle Dettling, Veerabahu Shanmugasundaram, Neil Raheja, Kimberly Jane Wade, Stephen Douglas Barrett, Victor Fedij, David Pocalyko, Smith Yvonne Dorothy, Stephen Fakhoury, Daniel Du, Karen Elaine Sexton, Lain-Yen Hu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5230-5233
A series of pantolactam based compounds were identified as potent antagonists for the androgen receptor (AR). Those that possessed properties suitable for topical delivery were evaluated in the validated Hamster Ear Model. Several compounds were foun
Autor:
Ling Li, Robert Conradi, Wen-Song Yue, Bella Osak, Smith Yvonne Dorothy, Jie Jack Li, Danielle Dettling, Satya Reddy, Veerabahu Shanmugasundaram, Manju Swaroop, Zenquan Wang, Laura L. Fleischer, Christy Xiaodong Ji, William Glen Harter, Laura Fitzgerald
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4932-4935
A series of aminomethylpyrazoles were prepared and evaluated using cell-based Smoothened β-lactamase reporter assay and Smoothened binding assay. Potent Smoothened antagonists 10k and 10l were found to inhibit hair growth in vivo in the C3H/HeN mous
Autor:
W. Allen Howard, Joseph S. Warmus, Haile Tecle, Smith Yvonne Dorothy, Wilbur R. Leopold, Stephen Douglas Barrett, James H. Fergus, Amy M. Delaney, Dan Marston, Alan R. Saltiel, Alexander James Bridges, Sophie LePage, Annette M. Doherty, Cathlin Marie Flamme, Sally Przybranowski, Judith Sebolt-Leopold, Robert M. Kennedy, Keri Van Becelaere, David T. Dudley, Michael Kaufman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:6501-6504
A novel series of benzhydroxamate esters derived from their precursor anthranilic acids have been prepared and have been identified as potent MEK inhibitors. 2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluoro-benzamide, CI-1040, was th
Autor:
Lorna Helen Mitchell, Bruce Allen Lefker, Stephen Fakhoury, Catherine R. Kostlan, Iula Donna Michele, Maria Nguyen, Lain-Yen Hu, Daniel Du, David Pocalyko, Danielle Dettling, Kimberly Jane Wade, Matthew Carroll, Smith Yvonne Dorothy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2176-2178
A series of diphenyl ethers was prepared and evaluated for androgen receptor antagonist activity in human androgen receptor binding and cellular functional assays. Analogs with potent in vitro activities were evaluated for topical in vivo efficacy in