Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Smith Kenneth GC"'
Autor:
Smith Kenneth GC
Publikováno v:
Journal of Translational Medicine, Vol 10, Iss Suppl 3, p I5 (2012)
Externí odkaz:
https://doaj.org/article/8158875a59294adeadf8ce7e063acbab
Autor:
Watts Richard A, Harper Lorraine, Williams Julie, Niederer Heather A, Carr Edward J, Lyons Paul A, Smith Kenneth GC
Publikováno v:
BMC Medical Genetics, Vol 10, Iss 1, p 121 (2009)
Abstract Background The genetic contribution to the aetiology of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is not well defined. Across different autoimmune diseases some genes with immunomodulatory roles, such as PTPN22,
Externí odkaz:
https://doaj.org/article/a297c4c799314d79a4d628a45f5d07e4
Autor:
Todd John A, Lowe Christopher E, Clatworthy Menna R, Carr Edward J, Wong Andrew, Vyse Timothy J, Kamesh Lavanya, Watts Richard A, Lyons Paul A, Smith Kenneth GC
Publikováno v:
BMC Medical Genetics, Vol 10, Iss 1, p 22 (2009)
Abstract Background Autoimmune diseases are complex and have genetic and environmental susceptibility factors. The objective was to test the genetic association of systemic lupus erythematosus (SLE) and anti-neutrophil cytoplasmic antibody (ANCA) –
Externí odkaz:
https://doaj.org/article/1b58057ef0004e99b4f8b360a89b8b12
Autor:
Chaudhry Afzal N, Woffendin Hayley B, Doggett Karen, Hatton Alexander, Koukoulaki Maria, Lyons Paul A, Smith Kenneth GC
Publikováno v:
BMC Genomics, Vol 8, Iss 1, p 64 (2007)
Abstract Background For expression profiling to have a practical impact in the management of immune-related disease it is essential that it can be applied to peripheral blood cells. Early studies have used total peripheral blood mononuclear cells, an
Externí odkaz:
https://doaj.org/article/806d30f5221649f7b2c2a3a79037d1df
Autor:
Guo, Shuang A, Bowyer, Georgina S, Ferdinand, John R, Maes, Mailis, Tuong, Zewen K, Gillman, Eleanor, Liao, Mingfeng, Lindeboom, Rik GH, Yoshida, Masahiro, Worlock, Kaylee, Gopee, Hudaa, Stephenson, Emily, Gao, Catherine A, Lyons, Paul A, Smith, Kenneth GC, Haniffa, Muzlifah, Meyer, Kerstin B, Nikolić, Marko Z, Zhang, Zheng, Wunderink, Richard G, Misharin, Alexander V, Dougan, Gordon, Navapurkar, Vilas, Teichmann, Sarah A, Conway Morris, Andrew, Clatworthy, Menna R
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 207:566-576
Rationale: Obesity affects 40% of U.S. adults, is associated with a proinflammatory state, and presents a significant risk factor for the development of severe coronavirus disease (COVID-19). To date, there is limited information on how obesity might
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e06241f4fda7bfb6aa0e6b3d8366813
https://doi.org/10.1164/rccm.202204-0751oc
https://doi.org/10.1164/rccm.202204-0751oc
Autor:
Potts, Martin, Fletcher-Etherington, Alice, Nightingale, Katie, Mescia, Federica, Bergamaschi, Laura, Calero-Nieto, Fernando J, Antrobus, Robin, Williamson, James, Cambridge Institute Of Therapeutic Immunology And Infectious Disease-National Institute Of Health Research (CITIID-NIHR) COVID BioResource Collaboration, Parsons, Harriet, Huttlin, Edward L, Kingston, Nathalie, Göttgens, Berthold, Bradley, John R, Lehner, Paul J, Matheson, Nicholas J, Smith, Kenneth GC, Wills, Mark R, Lyons, Paul A, Weekes, Michael P
Certain serum proteins, including C-reactive protein (CRP) and D-dimer, have prognostic value in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Nonetheless, these factors are non-specific, providing limited mechanistic in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db581f8e2a452564b33d76a7babdb8cd
https://www.repository.cam.ac.uk/handle/1810/350219
https://www.repository.cam.ac.uk/handle/1810/350219
Autor:
Ortiz-Fernández, Lourdes, Carmona, Elio G, Kerick, Martin, Lyons, Paul, Carmona, Francisco David, López Mejías, Raquel, Khor, Chiea Chuen, Grayson, Peter C, Tombetti, Enrico, Jiang, Lindi, Direskeneli, Haner, Saruhan-Direskeneli, Guher, Callejas-Rubio, José-Luis, Vaglio, Augusto, Salvarani, Carlo, Hernández-Rodríguez, Jose, Cid, Maria Cinta, Morgan, Ann W, Merkel, Peter A, Burgner, David, Smith, Kenneth Gc, Gonzalez-Gay, Miguel Angel, Sawalha, Amr H, Martin, Javier, Marquez, Ana
Objectives The number of susceptibility loci currently associated with vasculitis is lower than in other immune-mediated diseases due in part to small cohort sizes, a consequence of the low prevalence of vasculitides. This study aimed to identify new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf053e3ff6df46f75171fa393cd0283
https://hdl.handle.net/10481/80813
https://hdl.handle.net/10481/80813
Autor:
Needham, Edward J, Ren, Alexander L, Digby, Richard J, Norton, Emma J, Ebrahimi, Soraya, Outtrim, Joanne G, Chatfield, Doris A, Manktelow, Anne E, Leibowitz, Maya M, Newcombe, Virginia FJ, Doffinger, Rainer, Barcenas-Morales, Gabriela, Fonseca, Claudia, Taussig, Michael J, Burnstein, Rowan M, Samanta, Romit J, Dunai, Cordelia, Sithole, Nyarie, Ashton, Nicholas J, Zetterberg, Henrik, Gisslén, Magnus, Edén, Arden, Marklund, Emelie, Openshaw, Peter JM, Dunning, Jake, Griffiths, Michael J, Cavanagh, Jonathan, Breen, Gerome, Irani, Sarosh R, Elmer, Anne, Kingston, Nathalie, Summers, Charlotte, Bradley, John R, Taams, Leonie S, Michael, Benedict D, Bullmore, Edward T, Smith, Kenneth GC, Lyons, Paul A, Coles, Alasdair J, Menon, David K, Cambridge NeuroCOVID Group, CITIID-NIHR COVID-19 BioResource Collaboration, Cambridge NIHR Clinical Research Facility
COVID-19 is associated with neurological complications including stroke, delirium and encephalitis. Furthermore, a post-viral syndrome dominated by neuropsychiatric symptoms is common, and is seemingly unrelated to COVID-19 severity. The true frequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc8853514c773d5128aa844ae3b3d7f
https://www.repository.cam.ac.uk/handle/1810/341781
https://www.repository.cam.ac.uk/handle/1810/341781
Autor:
Krishna, Benjamin A, Lim, Eleanor Y, Mactavous, Lenette, NIHR BioResource Team, Lyons, Paul A, Doffinger, Rainer, Bradley, John R, Smith, Kenneth GC, Sinclair, John, Matheson, Nicholas J, Lehner, Paul J, Wills, Mark R, Sithole, Nyaradzai
BACKGROUND: There is currently no consensus on the diagnosis, definition, symptoms, or duration of COVID-19 illness. The diagnostic complexity of Long COVID is compounded in many patients who were or might have been infected with SARS-CoV-2 but not t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7154da476e328203303b4e6e69e0d28a
Autor:
Meng, Bo, Datir, Rawlings, Choi, Jinwook, CITIID-NIHR Bioresource COVID-19 Collaboration, Bradley, John R, Smith, Kenneth GC, Lee, Joo Hyeon, Gupta, Ravindra K
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike N-terminal domain (NTD) remains poorly characterized despite enrichment of mutations in this region across variants of concern (VOCs). Here, we examine the contribution of the NTD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad6b47d854b39dcccab691cdbae6a51