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pro vyhledávání: '"Smith Kathryn Jane"'
Autor:
Smith, Kathryn Jane
This thesis is not available on this repository until the author agrees to make it public. If you are the author of this thesis and would like to make your work openly available, please contact us: thesis@repository.cam.ac.uk.
The Library can su
The Library can su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e10605f6aa5dbafdc7b7018a94ebe31
Autor:
Melanie Washington, Lisa E. Ranshaw, Philip Alan Skone, James A. Bull, David W. Brown, Ilaria Giordano, Richard Martyn Angell, Vipulkumar Kantibhai Patel, Smith Kathryn Jane, Anthony William James Cooper, Martin Sims, Emma Vickerstaff, John A. Christopher, Lucy Hind, Inder Bhamra, Paul Bamborough, Lynsey H. Fazal
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4363-4368
2,4-Dianilino pyrimidines are well-known inhibitors of tyrosine kinases including lymphocyte specific kinase (Lck). Structure-activity relationships at the 4-position are discussed and rationalised. Examples bearing a 2-methyl-5-hydroxyaniline substi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ff5d5dadc32f06b148ca825a750008
https://doi.org/10.1016/j.bmcl.2007.04.029
https://doi.org/10.1016/j.bmcl.2007.04.029
Autor:
Jeremy John Payne, Geoff W. Mellor, Smith Kathryn Jane, Richard A. Williamson, Sebastien Andre Campos, Geoffrey J. Cutler, Caroline Whitworth, Mary A. Morse, Michael David Barker, Heather Hobbs, Rick P. C. Cousins, Duncan S. Holmes, Daniel Terence Tape, Paul Bamborough, John Martin Pritchard, John Liddle, Chris Ioannou
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(9)
The synthesis and SAR of a novel series of IKK2 inhibitors are described. Modification around the hinge binding region of the 7-azaindole led to a series of potent and selective inhibitors with good cellular activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac9d3089c47e68ac4f0cac67941fe59
https://pubmed.ncbi.nlm.nih.gov/19349179
https://pubmed.ncbi.nlm.nih.gov/19349179
Autor:
Penny A. Smee, Stephen Sean Flack, Steve Ludbrook, Ann Louise Walker, Timothy Longstaff, Mark James Bamford, Paul Bamborough, Katherine Louise Jones, Chun-wa Chung, Rosannah Pearson, Tony D. Angell, Dramane I. Laine, Stuart G. Cockerill, Smith Kathryn Jane, Richard Martyn Angell, Don O. Somers
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(15)
The biphenyl amides (BPAs) are a series of p38alpha MAP kinase inhibitors. Compounds are able to bind to the kinase in either the DFG-in or DFG-out conformation, depending on substituents. X-ray, binding, kinetic and cellular data are shown, providin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ab7c9ac6f3d7bf78d18847b8283213
https://pubmed.ncbi.nlm.nih.gov/18602262
https://pubmed.ncbi.nlm.nih.gov/18602262
Autor:
Duncan S. Holmes, Ann Louise Walker, Katherine Louise Jones, Chris D. Edwards, Dramane I. Laine, Don O. Somers, Paul Bamborough, Smith Kathryn Jane, Shila Patel, Jacky B. Buckton, Suzanne J. deBoeck, Richard Martyn Angell, Penny A. Smee, Nicola Mary Aston, Stuart G. Cockerill
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(15)
The biphenyl amides (BPAs) are a novel series of p38alpha MAP kinase inhibitor. The optimisation of the series to give compounds that are potent in an in vivo disease model is discussed. SAR is presented and rationalised with reference to the crystal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96035dc37dc9d60b0821a85dd7535ae
https://pubmed.ncbi.nlm.nih.gov/18614366
https://pubmed.ncbi.nlm.nih.gov/18614366
Autor:
Richard Martyn Angell, David W. Brown, Katherine Louise Jones, Smith Kathryn Jane, Ann Louise Walker, Penny A. Smee, Tim Longstaff, Paul Bamborough, Tony D. Angell, Stuart G. Cockerill, Chris D. Edwards, Don O. Somers, Murray J. B. Brown, Jacky B. Buckton, Malcolm Willson
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(1)
The biphenyl amides are a novel series of p38 MAP kinase inhibitors. Structure–activity relationships of the series against p38α are discussed with reference to the X-ray crystal structure of an example. The series was optimised rapidly to a compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86feebad65214ffc6c268e00b3237bb0
https://pubmed.ncbi.nlm.nih.gov/17981461
https://pubmed.ncbi.nlm.nih.gov/17981461
Autor:
Smith, Kathryn Jane
This thesis examines the way in which the doctrine of legitimate or reasonable expectations has developed in the common law of England and Australia. The examination aims to show the role of expectations in the modern re-balancing of interests betwee
Externí odkaz:
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339594
Autor:
Li, D.1,2, Ambrogio, L.1,3, Shimamura, T.1,4, Kubo, S.5, Takahashi, M.5, Chirieac, L. R.6, Padera, R. F.6, Shapiro, G. I.1,4, Baum, A.7, Himmelsbach, F.8, Rettig, W. J.7, Meyerson, M.1,3,4, Solca, F.7 flavio.solca@vie.boehringer-ingelheim.com, Greulich, H.1,3,4, Wong, K.-K.1,4
Publikováno v:
Oncogene. 8/7/2008, Vol. 27 Issue 34, p4702-4711. 10p. 1 Chart, 4 Graphs.
Autor:
Brenda Wren
First published in 1845, this directory has established an enviable reputation for the quantity and extent of its information on UK-registered medical practitioners. It provides mini career profiles of doctors listed A-Z by surname. Each record conta
Autor:
Wren, Brenda
First published in 1845, this directory has established an enviable reputation for the quantity and extent of its information on UK-registered medical practitioners. It provides mini career profiles of doctors listed A-Z by surname. Each record conta