Fetally-encoded GDF15 and maternal GDF15 sensitivity are major determinants of nausea and vomiting in human pregnancy

Autor: Fejzo, M, Rocha, N, Cimino, I, Lockhart, SM, Petry, C, Kay, RG, Burling, K, Barker, P, George, AL, Yasara, N, Premawardhena, A, Gong, S, Cook, E, Rainbow, K, Withers, DJ, Cortessis, V, Mullin, PM, MacGibbon, KW, Jin, E, Kam, A, Campbell, A, Polasek, O, Tzoneva, G, Gribble, FM, Yeo, GSH, Lam, BYH, Saudek, V, Hughes, IA, Ong, KK, Perry, JRB, Sutton Cole, A, Baumgarten, M, Welsh, P, Sattar, N, Smith, GCS, Charnock Jones, DS, Coll, AP, Meek, CL, Mettananda, S, Hayward, C, Mancuso, N, O’Rahilly, S

Publikováno v: bioRxiv

Human pregnancy is frequently accompanied by nausea and vomiting that may become severe and life-threatening, as in hyperemesis gravidarum (HG), the cause of which is unknown. Growth Differentiation Factor-15 (GDF15), a hormone known to act on the hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2811c5e20551036e23638b95c142a0ec
https://europepmc.org/articles/PMC10312505/

A critical review of the Cochrane meta-analysis of routine late-pregnancy ultrasound

Autor: Smith, Gcs

A Cochrane review of universal late-pregnancy ultrasound has been highly influential in guiding UK practice, concluding that it does not improve outcome. However, the meta-analysis combines trials that used diverse definitions of screen positive, wer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000b2c212320577eacf619779c27f820

External validation of prognostic models to predict stillbirth using International Prediction of Pregnancy Complications ( IPPIC ) Network database: individual participant data meta‐analysis

Autor: Allotey, J, Whittle, R, Snell, KIE, Smuk, M, Townsend, R, Dadelszen, P, Heazell, AEP, Magee, L, Smith, GCS, Sandall, J, Thilaganathan, B, Zamora, J, Riley, RD, Khalil, A, Thangaratinam, S, Coomarasamy, A, Kwong, A, Savitri, AI, Salvesen, KÅ, Bhattacharya, S, Uiterwaal, CSPM, Staff, AC, Andersen, LB, Olive, EL, Redman, C, Sletner, L, Daskalakis, G, Macleod, M, Abdollahain, M, Ramírez, JA, Massé, J, Audibert, F, Magnus, PM, Jenum, AK, Baschat, A, Ohkuchi, A, McAuliffe, FM, West, J, Askie, LM, Mone, F, Farrar, D, Zimmerman, PA, Smits, LJM, Riddell, C, Kingdom, JC, Post, J, Illanes, SE, Holzman, C, Kuijk, SMJ, Carbillon, L, Villa, PM, Eskild, A, Chappell, L, Prefumo, F, Velauthar, L, Seed, P, Oostwaard, M, Verlohren, S, Poston, L, Ferrazzi, E, Vinter, CA, Nagata, C, Brown, M, Vollebregt, KC, Takeda, S, Langenveld, J, Widmer, M, Saito, S, Haavaldsen, C, Carroli, G, Olsen, J, Wolf, H, Zavaleta, N, Eisensee, I, Vergani, P, Lumbiganon, P, Makrides, M, Facchinetti, F, Sequeira, E, Gibson, R, Ferrazzani, S, Frusca, T, Norman, JE, Figueiró‐Filho, EA, Lapaire, O, Laivuori, H, Lykke, JA, Conde‐Agudelo, A, Galindo, A, Mbah, A, Betran, AP, Herraiz, I, Trogstad, L, Smith, GGS, Steegers, EAP, Salim, R, Huang, T, Adank, A, Zhang, J, Meschino, WS, Browne, JL, Allen, RE, Costa, F Da Silva, Klipstein‐Grobusch, K, Crowther, CA, Jørgensen, JS, Forest, J‐C, Rumbold, AR, Mol, BW, Giguère, Y, Kenny, LC, Ganzevoort, W, Odibo, AO, Myers, J, Yeo, SA, Goffinet, F, McCowan, L, Pajkrt, E, Teede, HJ, Haddad, BG, Dekker, G, Kleinrouweler, EC, LeCarpentier, É, Roberts, CT, Groen, H, Skråstad, RB, Heinonen, S, Eero, K, Anggraini, D, Souka, A, Cecatti, JG, Monterio, I, Pillalis, A, Souza, R, Hawkins, LA, Gabbay‐Benziv, R, Crovetto, F, Figuera, F, Jorgensen, L, Dodds, J, Patel, M, Aviram, A, Papageorghiou, A, Khan, K

Objective: Stillbirth is a potentially preventable complication of pregnancy. Identifying women at risk can guide decisions on closer surveillance or timing of birth to prevent fetal death.Prognostic models have been developed to predict the risk of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::da4508a1294cd8e2338c8359705f30c0
https://researchonline.lshtm.ac.uk/id/eprint/4662124/1/Allotey_etal_2021-External-validation-of-prognostic-models.pdf

Placental polyamines regulate acetyl-coA and histone acetylation in a sex-specific manner

Autor: Francesca Gaccioli, Albert Koulman, Barbagallo R, Smith Gcs, Benjamin Jenkins, Aye Ilmh, Andrew J. Murray, D.S. Charnock-Jones, Sungsam Gong, Avellino G

Fetal sex differences play an important role in the pathophysiology of several placenta-related pregnancy complications. We previously reported that the maternal circulating level of a polyamine metabolite was altered in a fetal sex-specific manner,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9b1fa5fab3bbd2b6c695c1d512944af1
https://doi.org/10.1101/2021.06.09.447192

The risk of perinatal death at term

Autor: Smith, Gcs

Preventing stillbirth has been increasingly recognised as an issue in obstetric care over recent years. Death of a normally formed baby at term is a particular focus as the loss could often have been prevented had the baby been known to be at risk. R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b964bae53f8785f710412eaa82c2da9c