Zobrazeno 1 - 10
of 364
pro vyhledávání: '"Smith EG"'
Autor:
Smith Eg, Myers R, A S Walker, Colin Campbell, Do T, Alexander E, David Wyllie, Robinson E, D W Crook, Nikolayevskyy
Publikováno v:
Journal of Infection. 85:31-39
BackgroundThe prevalence, association with disease status, and public health impact of infection with mixtures of M. tuberculosis strains is unclear, in part due to limitations of existing methods for detecting mixed infections.MethodsWe developed an
A photocatalytic method for the alpha-selective hydroaminoalkylation of cinnamate esters has been developed. The reaction involves the regioselective addition of alpha-aminoalkyl radicals generated from aniline derivatives or aliphatic amines to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d86d9f0c13b326c14574a8071b199757
https://doi.org/10.26434/chemrxiv.14210588.v1
https://doi.org/10.26434/chemrxiv.14210588.v1
Autor:
Yang, Y, Walker, TM, Walker, AS, Wilson, DJ, Peto, TEA, Crook, DW, Shamout, F, Zhu, T, Clifton, DA, Arandjelovic, I, Comas, I, Farhat, MR, Gao, Q, Sintchenko, V, Van Soolingen, D, Hoosdally, S, Cruz, ALG, Carter, J, Grazian, C, Earle, SG, Kouchaki, S, Fowler, PW, Iqbal, Z, Hunt, M, Smith, EG, Rathod, P, Jarrett, L, Matias, D, Cirillo, DM, Borroni, E, Battaglia, S, Ghodousi, A, Spitaleri, A, Cabibbe, A, Tahseen, S, Nilgiriwala, K, Shah, S, Rodrigues, C, Kambli, P, Surve, U, Khot, R, Niemann, S, Kohl, T, Merker, M, Hoffmann, H, Molodtsov, N, Plesnik, S, Ismail, N, Omar, SV, Thwaites, G, Thuong, NTT, Nhung, HN, Srinivasan, V, Moore, D, Coronel, J, Solano, W, Gao, GF, He, G, Zhao, Y, Ma, A, Liu, C, Zhu, B, Laurenson, I, Claxton, P, Koch, A, Wilkinson, R, Lalvani, A, Posey, J, Gardy, J, Werngren, J, Paton, N, Jou, R, Wu, M-H, Lin, W-H, Ferrazoli, L, De Oliveira, RS
Motivation Resistance co-occurrence within first-line anti-tuberculosis (TB) drugs is a common phenomenon. Existing methods based on genetic data analysis of Mycobacterium tuberculosis (MTB) have been able to predict resistance of MTB to individual d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::053aeb8d43a7620a0a0a257e79d9f346
http://hdl.handle.net/10044/1/77500
http://hdl.handle.net/10044/1/77500
Autor:
Wilson, DJ, Crook, DW, Peto, TEA, Walker, AS, Hoosdally, SJ, Gibertoni Cruz, AL, Carter, J, Grazian, C, Earle, SG, Kouchaki, S, Lachapelle, A, Yang, Y, Clifton, DA, Fowler, PW, Iqbal, Z, Hunt, M, Knaggs, J, Smith, EG, Rathod, P, Jarrett, L, Matias, D, Cirillo, DM, Borroni, E, Battaglia, S, Ghodousi, A, Spitaleri, A, Cabibbe, A, Tahseen, S, Nilgiriwala, K, Shah, S, Rodrigues, C, Kambli, P, Surve, U, Khot, R, Niemann, S, Kohl, TA, Merker, M, Hoffmann, H, Todt, K, Plesnik, S, Ismail, N, Omar, SV, Joseph, L, Thwaites, G, Thuong, TNT, Ngoc, NH, Srinivasan, V, Walker, TM, Moore, D, Coronel, J, Solano, W, Gao, GF, He, G, Zhao, Y, Liu, C, Ma, A, Zhu, B, Laurenson, I, Claxton, P, Koch, A, Wilkinson, R, Lalvani, A, Posey, J, Gardy, J, Werngren, J, Paton, N, Jou, R, Wu, M-H, Lin, W-H, Ferrazoli, L, De Oliveira, RS, Arandjelovic, I, Chaiprasert, A, Comas, I, Roig, CJ, Drobniewski, FA, Farhat, MR, Gao, Q, Hee, ROT, Sintchenko, V, Supply, P, Van Soolingen, D
Publikováno v:
Molecular Biology and Evolution
Molecular Biology and Evolution, 2020, 37 (8), pp.2450-2460. ⟨10.1093/molbev/msaa069⟩
Molecular Biology and Evolution, Oxford University Press (OUP), 2020, 37 (8), pp.2450-2460. ⟨10.1093/molbev/msaa069⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname
Molecular Biology and Evolution, 2020, 37 (8), pp.2450-2460. ⟨10.1093/molbev/msaa069⟩
Molecular Biology and Evolution, Oxford University Press (OUP), 2020, 37 (8), pp.2450-2460. ⟨10.1093/molbev/msaa069⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname
11 págs, 4 figuras y fórmulas matemáticas. Material suplementario en: http://dx.doi.org/10.1093/molbev/msaa069
The dN/dS ratio provides evidence of adaptation or functional constraint in protein-coding genes by quantifying the relative excess
The dN/dS ratio provides evidence of adaptation or functional constraint in protein-coding genes by quantifying the relative excess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f28734013613db456521c1a9a29560
https://doi.org/10.1101/523316
https://doi.org/10.1101/523316
Autor:
Smith Eg, Anne-Sophie Walker, Foster D, David Griffiths, Hoosdally Sj, Kate E. Dingle, Derrick W. Crook, Yifei Xu, Alasdair T. M. Hubbard, George S, Pankhurst L, Priti Rathod, Michael D Morgan, Esther Robinson, Samantha Thulborn, Sanderson N, Tim E. A. Peto
Sequencing of pathogen DNA directly from clinical samples offers the possibilities of rapid diagnosis, faster antimicrobial resistance prediction and enhanced outbreak investigation. The approach is especially advantageous for infections caused by sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8df8de10508ff19af4e07b93488cf50f
https://doi.org/10.1101/490417
https://doi.org/10.1101/490417
Autor:
CRyPTIC Consortium, 100000 Genomes Project, Allix-Beguec, C, Arandjelovic, I, Bi, L, Beckert, P, Bonnet, M, Bradley, P, Cabibbe, AM, Cancino-Munoz, I, Caulfield, MJ, Chaiprasert, A, Cirillo, DM, Clifton, D, Comas, I, Crook, DW, De Filippo, MR, de Neeling, H, Diel, R, Drobniewski, FA, Faksri, K, Farhat, MR, Fleming, J, Fowler, P, Fowler, TA, Gao, Q, Gardy, J, Gascoyne-Binzi, D, Gibertoni-Cruz, A-L, Gil-Brusola, A, Golubchik, T, Gonzalo, X, Grandjean, L, He, G, Guthrie, JL, Hoosdally, S, Hunt, M, Iqbal, Z, Ismail, N, Johnston, J, Khanzada, FM, Khor, CC, Kohl, TA, Kong, C, Lipworth, S, Liu, Q, Maphalala, G, Martinez, E, Mathys, V, Merker, M, Miotto, P, Mistry, N, Moore, DAJ, Murray, M, Niemann, S, Ong, RT-H, Peto, TEA, Posey, JE, Prammananan, T, Pym, A, Rodrigues, C, Rodrigues, M, Rodwell, T, Rossolini, GM, Padilla, ES, Schito, M, Shen, X, Shendure, J, Sintchenko, V, Sloutsky, A, Smith, EG, Snyder, M, Soetaert, K, Starks, AM, Supply, P, Suriyapol, P, Tahseen, S, Tang, P, Teo, Y-Y, Thuong, TNT, Thwaites, G, Tortoli, E, Omar, SV, van Soolingen, D, Walker, AS, Walker, TM, Wilcox, M, Wilson, DJ, Wyllie, D, Yang, Y, Zhang, H, Zhao, Y, Zhu, B
Publikováno v:
NEW ENGLAND JOURNAL OF MEDICINE
r-FISABIO. Repositorio Institucional de Producción Científica
instname
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
r-FISABIO. Repositorio Institucional de Producción Científica
instname
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Background: The World Health Organization recommends drug-susceptibility testing of Mycobacterium tuberculosis complex for all patients with tuberculosis to guide treatment decisions and improve outcomes. Whether DNA sequencing can be used to accurat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6ef1d353d9cedec88a579420268d3924
https://fundanet.fisabio.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=2960
https://fundanet.fisabio.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=2960
Autor:
Ajileye, A, Alvarez, N, Merker, M, Walker, TM, Akter, S, Brown, K, Moradigaravand, D, Schön, T, Andres, S, Schleusener, V, Omar, SV, Coll, F, Huang, H, Diel, R, Ismail, N, Parkhill, J, De Jong, BC, Peto, TEA, Crook, DW, Niemann, S, Robledo, J, Smith, EG, Peacock, SJ, Köser, CU
We demonstrated that some non-synonymous and synonymous mutations in $\textit{gyrA}$ in $\textit{Mycobacterium tuberculosis}$ result in systematic false-resistance results to fluoroquinolones using the Hain GenoType MTBDRsl assays (version 1 and 2) b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2bfd4245806173ce4d86ee7f9d8065
https://www.repository.cam.ac.uk/handle/1810/263370
https://www.repository.cam.ac.uk/handle/1810/263370
Autor:
Pankhurst, LJ, Elias, C, Votintseva, AA, Walker, TM, Davies, J, Fermont, JM, Gascoyne-Binzi, DM, Kohl, TA, Kong, C, Lemaitre, N, Niemann, S, Paul, J, Rogers, TR, Roycroft, E, Smith, EG, Supply, P, Tang, P, Wilcox, MH, Wordsworth, S, Wyllie, D, Xu, L, Crook, DW
Background Slow and cumbersome laboratory diagnostics for Mycobacterium tuberculosis complex (MTBC) risk delayed treatment and poor patient outcomes. Whole-genome sequencing (WGS) could potentially provide a rapid and comprehensive diagnostic solutio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::830d6034798a7641e3043a9a24fafdb8
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