Optimization of a Piperidine CD4-Mimetic Scaffold Sensitizing HIV-1 Infected Cells to Antibody-Dependent Cellular Cytotoxicity.

Autor: Lee D; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Niu L; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, United States., Ding S; Centre de Recherche du CHUM, Montréal, Quebec H2X 0A9, Canada., Zhu H; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Tolbert WD; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, United States., Medjahed H; Centre de Recherche du CHUM, Montréal, Quebec H2X 0A9, Canada., Beaudoin-Bussières G; Centre de Recherche du CHUM, Montréal, Quebec H2X 0A9, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Quebec H3T 1J4, Canada., Abrams C; Department of Chemical and Biological Engineering, Drexel University, Philadelphia, Pennsylvania 19104, United States., Finzi A; Centre de Recherche du CHUM, Montréal, Quebec H2X 0A9, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Quebec H3T 1J4, Canada., Pazgier M; Infectious Disease Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, United States., Smith AB 3rd; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2024 Oct 28; Vol. 15 (11), pp. 1961-1969. Date of Electronic Publication: 2024 Oct 28 (Print Publication: 2024).

The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity.

Autor: Marchitto L; Centre de Recherche du CHUM, Montréal, Québec, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Québec, Canada., Richard J; Centre de Recherche du CHUM, Montréal, Québec, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Québec, Canada., Prévost J; Centre de Recherche du CHUM, Montréal, Québec, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Québec, Canada., Tauzin A; Centre de Recherche du CHUM, Montréal, Québec, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Québec, Canada., Yang D; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Chiu T-J; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Chen H-C; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Díaz-Salinas MA; Department of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA., Nayrac M; Centre de Recherche du CHUM, Montréal, Québec, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Québec, Canada., Benlarbi M; Centre de Recherche du CHUM, Montréal, Québec, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Québec, Canada., Beaudoin-Bussières G; Centre de Recherche du CHUM, Montréal, Québec, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Québec, Canada., Anand SP; Centre de Recherche du CHUM, Montréal, Québec, Canada.; Department of Microbiology and Immunology, McGill University, Montreal, Canada., Dionne K; Centre de Recherche du CHUM, Montréal, Québec, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Québec, Canada., Bélanger É; Centre de Recherche du CHUM, Montréal, Québec, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Québec, Canada., Chatterjee D; Centre de Recherche du CHUM, Montréal, Québec, Canada., Medjahed H; Centre de Recherche du CHUM, Montréal, Québec, Canada., Bourassa C; Centre de Recherche du CHUM, Montréal, Québec, Canada., Tolbert WD; Infectious Diseases Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA., Hahn BH; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Munro JB; Department of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.; Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA., Pazgier M; Infectious Diseases Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA., Smith AB 3rd; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Finzi A; Centre de Recherche du CHUM, Montréal, Québec, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Québec, Canada.; Department of Microbiology and Immunology, McGill University, Montreal, Canada.

Publikováno v: Journal of virology [J Virol] 2024 Oct 22; Vol. 98 (10), pp. e0101624. Date of Electronic Publication: 2024 Sep 09.

The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC.

Autor: Richard J; Centre de Recherche du CHUM, Montréal, Québec, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Québec, Canada., Grunst MW; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA., Niu L; Infectious Diseases Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Díaz-Salinas MA; Department of Microbiology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA., Tolbert WD; Infectious Diseases Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Marchitto L; Centre de Recherche du CHUM, Montréal, Québec, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Québec, Canada., Zhou F; Unit on Structural Biology, Division of Basic and Translational Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA., Bourassa C; Centre de Recherche du CHUM, Montréal, Québec, Canada., Yang D; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA., Chiu TJ; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA., Chen HC; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA., Benlarbi M; Centre de Recherche du CHUM, Montréal, Québec, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Québec, Canada., Gottumukkala S; Infectious Diseases Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Li W; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA., Dionne K; Centre de Recherche du CHUM, Montréal, Québec, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Québec, Canada., Bélanger É; Centre de Recherche du CHUM, Montréal, Québec, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Québec, Canada., Chatterjee D; Centre de Recherche du CHUM, Montréal, Québec, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Québec, Canada., Medjahed H; Centre de Recherche du CHUM, Montréal, Québec, Canada., Hendrickson WA; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.; Department of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA., Sodroski J; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Microbiology, Harvard Medical School, Boston, Massachusetts, USA., Lang ZC; Laboratory of Cell Biology, National Cancer Institute, NIH, Bethesda, USA., Morton AJ; Laboratory of Cell Biology, National Cancer Institute, NIH, Bethesda, USA., Huang RK; Laboratory of Cell Biology, National Cancer Institute, NIH, Bethesda, USA., Matthies D; Unit on Structural Biology, Division of Basic and Translational Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA., Smith AB 3rd; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA., Mothes W; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA., Munro JB; Department of Microbiology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.; Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Pazgier M; Infectious Diseases Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Finzi A; Centre de Recherche du CHUM, Montréal, Québec, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, Québec, Canada.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Aug 27. Date of Electronic Publication: 2024 Aug 27.

Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in presence of CD4-mimetics.

Autor: Tauzin A; Centre de Recherche du CHUM, Montreal, QC, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC, Canada., Marchitto L; Centre de Recherche du CHUM, Montreal, QC, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC, Canada., Bélanger É; Centre de Recherche du CHUM, Montreal, QC, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC, Canada., Benlarbi M; Centre de Recherche du CHUM, Montreal, QC, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC, Canada., Beaudoin-Bussières G; Centre de Recherche du CHUM, Montreal, QC, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC, Canada., Prévost J; Centre de Recherche du CHUM, Montreal, QC, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC, Canada., Yang D; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA., Chiu TJ; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA., Chen HC; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA., Bourassa C; Centre de Recherche du CHUM, Montreal, QC, Canada., Medjahed H; Centre de Recherche du CHUM, Montreal, QC, Canada., Korzeniowski MK; Infectious Diseases Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Gottumukkala S; Infectious Diseases Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Tolbert WD; Infectious Diseases Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Richard J; Centre de Recherche du CHUM, Montreal, QC, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC, Canada., Smith AB 3rd; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA., Pazgier M; Infectious Diseases Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Finzi A; Centre de Recherche du CHUM, Montreal, QC, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC, Canada.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Jun 04. Date of Electronic Publication: 2024 Jun 04.

Total Synthesis of the Reported Structure of Neaumycin B.

Autor: Ding J; Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Smith AB 3rd; Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2023 Aug 23; Vol. 145 (33), pp. 18240-18246. Date of Electronic Publication: 2023 Aug 10.