Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells

Autor: Dolatshad, H, Pellagatti, A, Fernandez-Mercado, M, Yip, B H, Malcovati, L, Attwood, M, Przychodzen, B, Sahgal, N, Kanapin, A A, Lockstone, H, Scifo, L, Vandenberghe, P, Papaemmanuil, E, Smith, C W J, Campbell, P J, Ogawa, S, Maciejewski, J P, Cazzola, M, Savage, K I, Boultwood, J

Publikováno v: Dolatshad, H, Pellagatti, A, Fernandez-Mercado, M, Yip, BH, Malcovati, L, Attwood, M, Przychodzen, B, Sahgal, N, Kanapin, AA, Lockstone, H, Scifo, L, Vandenberghe, P, Papaemmanuil, E, Smith, CWJ, Campbell, PJ, Ogawa, S, Maciejewski, JP, Cazzola, M, Savage, KI & Boultwood, J 2015, ' Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells ', Leukemia, vol. 29, no. 5, pp. 1092-1103 . https://doi.org/10.1038/leu.2014.331
Leukemia

The splicing factor SF3B1 is the most commonly mutated gene in the myelodysplastic syndromes (MDS), particularly in patients with refractory anemia with ring sideroblasts (RARS). We investigated the functional effects of SF3B1 disruption in myeloid c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3974c7690112c51af1f6a5a7d1fe1240
https://pure.qub.ac.uk/en/publications/disruption-of-sf3b1-results-in-deregulated-expression-and-splicing-of-key-genes-and-pathways-in-myelodysplastic-syndrome-hematopoietic-stem-and-progenitor-cells(1cd3cf12-cf6e-4f30-b6c0-83860f8c96f3).html

Crystallographic analysis of PTB-Raver1 interactions involved in regulation of alternative splicing

Autor: Joshi, A., Coelho, M. B., Kotik-Kogan, O., Simpson, P. J., Matthews, S. J., Smith, C. W. J., Curry, S.

Publikováno v: Structure 19, 1816-1825 (2011). doi:10.1016/j.str.2011.09.020

The polypyrimidine tract-binding protein (PTB) is an important regulator of alternative splicing. PTB-regulated splicing of α-tropomyosin is enhanced by Raver1, a protein with four PTB-Raver1 interacting motifs (PRIs) that bind to the helical face o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1108::624255bdfe184106eee96eb0d30d0e91
https://bib-pubdb1.desy.de/record/94698

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Regulation of alternative splicing by PTB and associated factors.

Autor: Spellman R; Department of Biochemistry, University of Cambridge, 80, Tennis Court Road, Cambridge CB2 1GA, UK., Rideau A, Matlin A, Gooding C, Robinson F, McGlincy N, Grellscheid SN, Southby J, Wollerton M, Smith CW

Publikováno v: Biochemical Society transactions [Biochem Soc Trans] 2005 Jun; Vol. 33 (Pt 3), pp. 457-60.