Age-associated mitochondrial DNA mutations cause metabolic remodelling that contributes to accelerated intestinal tumorigenesis.

Autor: Smith AL; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Whitehall JC; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Bradshaw C; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Gay D; Cancer Research UK Beatson Institute, Switchback Road, Glasgow, G61 1BD, UK.; Institute of Cancer Sciences, University of Glasgow, Switchback Road, Glasgow. G61 1QH, UK., Robertson F; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Blain AP; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Hudson G; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Pyle A; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Houghton D; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Hunt M; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Sampson JN; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Stamp C; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Mallett G; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Amarnath S; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Leslie J; Newcastle Fibrosis Research Group, Biosciences Institute, Newcastle upon Tyne, NE2 4HH, UK., Oakley F; Newcastle Fibrosis Research Group, Biosciences Institute, Newcastle upon Tyne, NE2 4HH, UK., Wilson L; Newcastle Cancer Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH UK., Baker A; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Russell OM; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Johnson R; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Richardson CA; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Gupta B; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., McCallum I; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., McDonald SA; Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Kelly S; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Mathers JC; Human Nutrition Research Centre, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH., Heer R; Newcastle Cancer Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH UK., Taylor RW; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Perkins ND; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Turnbull DM; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Sansom OJ; Cancer Research UK Beatson Institute, Switchback Road, Glasgow, G61 1BD, UK.; Institute of Cancer Sciences, University of Glasgow, Switchback Road, Glasgow. G61 1QH, UK., Greaves LC; Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

Publikováno v: Nature cancer [Nat Cancer] 2020 Oct; Vol. 1 (10), pp. 976-989. Date of Electronic Publication: 2020 Sep 21.