Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Smita Matkar"'
Autor:
Esther R. Berko, Gabriela M. Witek, Smita Matkar, Zaritza O. Petrova, Megan A. Wu, Courtney M. Smith, Alex Daniels, Joshua Kalna, Annie Kennedy, Ivan Gostuski, Colleen Casey, Kateryna Krytska, Mark Gerelus, Dean Pavlick, Susan Ghazarian, Julie R. Park, Araz Marachelian, John M. Maris, Kelly C. Goldsmith, Ravi Radhakrishnan, Mark A. Lemmon, Yaël P. Mossé
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Activating point mutations in Anaplastic Lymphoma Kinase (ALK) have positioned ALK as the only mutated oncogene tractable for targeted therapy in neuroblastoma. Cells with these mutations respond to lorlatinib in pre-clinical studies, provid
Externí odkaz:
https://doaj.org/article/c0e4bcb6136d4cc7a5072df22f3d7275
Autor:
Xianxin Hua, Donita C. Brady, Bruce D. Freedman, Xin He, Yuan Wu, Haoren Wang, Yuanyuan Liu, Smita Matkar, Katherine M. Szigety, Corbett T. Berry, Jian Ma, Caroline I. Davis, Zijie Feng, Kayla E. Paulosky, Rebecca A. Glynn, Bryson W. Katona
Supplemental Figure S1: Menin inhibition has minimal effects on cell growth in colon cancer cells. Supplemental Figure S2: Inhibition of menin selectively sensitizes colon cancer cells to iEGFRs. Supplemental Figure S3: BAPTA rescues cells from the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d3072f660a95a321900944e5705d8be
https://doi.org/10.1158/0008-5472.22423937
https://doi.org/10.1158/0008-5472.22423937
Autor:
Xianxin Hua, Donita C. Brady, Bruce D. Freedman, Xin He, Yuan Wu, Haoren Wang, Yuanyuan Liu, Smita Matkar, Katherine M. Szigety, Corbett T. Berry, Jian Ma, Caroline I. Davis, Zijie Feng, Kayla E. Paulosky, Rebecca A. Glynn, Bryson W. Katona
Menin is a nuclear epigenetic regulator that can both promote and suppress tumor growth in a highly tissue-specific manner. The role of menin in colorectal cancer, however, remains unclear. Here, we demonstrate that menin was overexpressed in colorec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::befa6fcba17e107346b518a675e30375
https://doi.org/10.1158/0008-5472.c.6511616.v1
https://doi.org/10.1158/0008-5472.c.6511616.v1
Autor:
Xianxin Hua, Donita C. Brady, Bruce D. Freedman, Xin He, Yuan Wu, Haoren Wang, Yuanyuan Liu, Smita Matkar, Katherine M. Szigety, Corbett T. Berry, Jian Ma, Caroline I. Davis, Zijie Feng, Kayla E. Paulosky, Rebecca A. Glynn, Bryson W. Katona
This supplementary file contains methods for menin immunohistochemistry, reagents, cell culture, proliferation assays, western blotting, plasmids and transfections, RT-PCR, cell visualization assays including clonogenicity, H&E staining, and live cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69406dd38f4c362bc67af155c6d392cf
https://doi.org/10.1158/0008-5472.22423934
https://doi.org/10.1158/0008-5472.22423934
Autor:
Alberto D. Guerra, Annie Kennedy, Cynthia Adams, Rawan Shraim, Amber K. Weiner, Chuan Chen, Kateryna Krytska, Colleen Larmour, Smita Matkar, Dimiter Dimitrov, Dontcho V. Jelev, Yael P. Mossé
Publikováno v:
Cancer Research. 82:2012-2012
Introduction: ALK is a lineage restricted oncoprotein expressed on the cell surface of NBL as wild-type (WT), mutated, or amplified, and recently shown to be overexpressed in FP RMS. Small molecule inhibitors have shown potent efficacy in NBL with AL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6a0775cb3d2dbd569035aae8f034154
https://doi.org/10.1158/1538-7445.am2022-2012
https://doi.org/10.1158/1538-7445.am2022-2012
Autor:
Lei Wang, Chiying An, Xiuheng Liu, Xiangchen Kong, Xin He, Xianxin Hua, Smita Matkar, Gengchen Xie
Publikováno v:
Cancer Biology & Therapy. 18:229-236
The prevalence of neuroendocrine tumors (NETs) has recently been increasing. Although various drugs such as Octreotide and its analogs show certain efficacy, NETs in many patients progress and metastasize. It is desirable to develop new interventions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a6eadd3807deb0c550c3ec2b69794a
https://doi.org/10.1080/15384047.2017.1294291
https://doi.org/10.1080/15384047.2017.1294291
Autor:
Smita Matkar, Bruce D. Freedman, Xin He, Zijie Feng, Kayla E Paulosky, Rebecca A Glynn, Xianxin Hua, Haoren Wang, Katherine M Szigety, Corbett T. Berry, Caroline I. Davis, Yuan Wu, Bryson W. Katona, Yuanyuan Liu, Donita C. Brady, Jian Ma
Publikováno v:
Cancer Res
Menin is a nuclear epigenetic regulator that can both promote and suppress tumor growth in a highly tissue-specific manner. The role of menin in colorectal cancer, however, remains unclear. Here, we demonstrate that menin was overexpressed in colorec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985c47ca758602c81320e60c3b24293b
https://pubmed.ncbi.nlm.nih.gov/30877106
https://pubmed.ncbi.nlm.nih.gov/30877106
Publikováno v:
Seminars in cancer biology. 50
FOXO proteins are a sub-group of a superfamily of forkhead box (FOX)-containing transcription factors (TFs). FOXOs play an important role in regulating a plethora of biological activities ranging from development, cell signaling, and tumorigenesis to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beec1b33c9d357c62113af0a582542b6
https://pubmed.ncbi.nlm.nih.gov/29410116
https://pubmed.ncbi.nlm.nih.gov/29410116
Publikováno v:
American journal of cancer research. 7(7)
Inhibitors of the HER2/PI3K/AKT pathway are being developed, and shown promise in clinical trials for various types of cancers. However, development of drug resistance is a challenging problem for therapy. Elucidating various adaptive pathways leadin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::57d500a01981ae9156bfcb436d1412e4
https://pubmed.ncbi.nlm.nih.gov/28744398
https://pubmed.ncbi.nlm.nih.gov/28744398
Autor:
Jing Huang, Natalia A. Veniaminova, Ming Lei, Smita Matkar, Ke Wan, Buddha Gurung, Juanita L. Merchant, Xianxin Hua, Bingbing Wan
Publikováno v:
Nature. 482:542-546
Menin is a tumour suppressor protein whose loss or inactivation causes multiple endocrine neoplasia 1 (MEN1), a hereditary autosomal dominant tumour syndrome that is characterized by tumorigenesis in multiple endocrine organs. Menin interacts with ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d41b7f0762ad4d211170c1aeb878a21
https://doi.org/10.1038/nature10806
https://doi.org/10.1038/nature10806