Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Smita Krishnaswamy"'
Autor:
Liam Hodgson, Yue Li, Yasser Iturria-Medina, Jo Anne Stratton, Guy Wolf, Smita Krishnaswamy, David A. Bennett, Danilo Bzdok
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-19 (2024)
Abstract Late onset Alzheimer’s disease (AD) is a progressive neurodegenerative disease, with brain changes beginning years before symptoms surface. AD is characterized by neuronal loss, the classic feature of the disease that underlies brain atrop
Externí odkaz:
https://doaj.org/article/7d8c85b5304d4fe2a88eedbabca21c21
Autor:
Ho-Joon Lee, Lee H. Schwamm, Lauren H. Sansing, Hooman Kamel, Adam de Havenon, Ashby C. Turner, Kevin N. Sheth, Smita Krishnaswamy, Cynthia Brandt, Hongyu Zhao, Harlan Krumholz, Richa Sharma
Publikováno v:
npj Digital Medicine, Vol 7, Iss 1, Pp 1-22 (2024)
Abstract Determining acute ischemic stroke (AIS) etiology is fundamental to secondary stroke prevention efforts but can be diagnostically challenging. We trained and validated an automated classification tool, StrokeClassifier, using electronic healt
Externí odkaz:
https://doaj.org/article/783bc7ef231042f9a5f3a11d5af6d3ea
Autor:
Manik Kuchroo, Marcello DiStasio, Eric Song, Eda Calapkulu, Le Zhang, Maryam Ige, Amar H. Sheth, Abdelilah Majdoubi, Madhvi Menon, Alexander Tong, Abhinav Godavarthi, Yu Xing, Scott Gigante, Holly Steach, Jessie Huang, Guillaume Huguet, Janhavi Narain, Kisung You, George Mourgkos, Rahul M. Dhodapkar, Matthew J. Hirn, Bastian Rieck, Guy Wolf, Smita Krishnaswamy, Brian P. Hafler
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Due to commonalities in pathophysiology, age-related macular degeneration (AMD) represents a uniquely accessible model to investigate therapies for neurodegenerative diseases, leading us to examine whether pathways of disease progression are
Externí odkaz:
https://doaj.org/article/7d518075ed264723a3afcab7d1e39ef3
Autor:
Carl A. Pierce, Lip Nam Loh, Holly R. Steach, Natalia Cheshenko, Paula Preston-Hurlburt, Fengrui Zhang, Stephanie Stransky, Leah Kravets, Simone Sidoli, William Philbrick, Michel Nassar, Smita Krishnaswamy, Kevan C. Herold, Betsy C. Herold
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 11 (2023)
Herpes simplex virus type 2 (HSV-2) coinfection is associated with increased HIV-1 viral loads and expanded tissue reservoirs, but the mechanisms are not well defined. HSV-2 recurrences result in an influx of activated CD4+ T cells to sites of viral
Externí odkaz:
https://doaj.org/article/f5b10ba6f97a40c4b40cb5a78e9c44a7
Autor:
Rahul M. Dhodapkar, Emily Li, Kristen Nwanyanwu, Ron Adelman, Smita Krishnaswamy, Jay C. Wang
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Optical coherence tomography angiography (OCTA) is an emerging non-invasive technique for imaging the retinal vasculature. While there are many promising clinical applications for OCTA, determination of image quality remains a challenge. We
Externí odkaz:
https://doaj.org/article/1b5d2ef12d0f4586904f3d03abe8d759
Autor:
Valerie A Tornini, Liyun Miao, Ho-Joon Lee, Timothy Gerson, Sarah E Dube, Valeria Schmidt, François Kroll, Yin Tang, Katherine Du, Manik Kuchroo, Charles E Vejnar, Ariel Alejandro Bazzini, Smita Krishnaswamy, Jason Rihel, Antonio J Giraldez
Publikováno v:
eLife, Vol 12 (2023)
Thousands of long intergenic non-coding RNAs (lincRNAs) are transcribed throughout the vertebrate genome. A subset of lincRNAs enriched in developing brains have recently been found to contain cryptic open-reading frames and are speculated to encode
Externí odkaz:
https://doaj.org/article/3eb5c87de1364a89b649924c5e5d58a1
Autor:
Emily V. Dutrow, Deena Emera, Kristina Yim, Severin Uebbing, Acadia A. Kocher, Martina Krenzer, Timothy Nottoli, Daniel B. Burkhardt, Smita Krishnaswamy, Angeliki Louvi, James P. Noonan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Human Accelerated Regions (HARs) are prime candidates for driving the evolution of uniquely human traits. Using humanized mice, the authors show how one HAR alters gene expression during embryonic development, yielding insight into HAR function.
Externí odkaz:
https://doaj.org/article/1b2726ac798e42daba34db9c56f86f99
Autor:
Ana Luisa Perdigoto, Songyan Deng, Katherine C. Du, Manik Kuchroo, Daniel B. Burkhardt, Alexander Tong, Gary Israel, Marie E. Robert, Stuart P. Weisberg, Nancy Kirkiles-Smith, Angeliki M. Stamatouli, Harriet M. Kluger, Zoe Quandt, Arabella Young, Mei-Ling Yang, Mark J. Mamula, Jordan S. Pober, Mark S. Anderson, Smita Krishnaswamy, Kevan C. Herold
Publikováno v:
JCI Insight, Vol 7, Iss 17 (2022)
Checkpoint inhibitors (CPIs) targeting programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) and cytotoxic T lymphocyte antigen 4 (CTLA-4) have revolutionized cancer treatment but can trigger autoimmune complications, including CPI-induced diab
Externí odkaz:
https://doaj.org/article/f9630643cb2a4034a1a840623dc88f6b
Autor:
Dennis Shung, Jessie Huang, Egbert Castro, J. Kenneth Tay, Michael Simonov, Loren Laine, Ramesh Batra, Smita Krishnaswamy
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Acute gastrointestinal bleeding is the most common gastrointestinal cause for hospitalization. For high-risk patients requiring intensive care unit stay, predicting transfusion needs during the first 24 h using dynamic risk assessment may im
Externí odkaz:
https://doaj.org/article/70ecc46b9e1640a0ba5d4390d8202c6e
Autor:
Fatima Mostefai, Isabel Gamache, Arnaud N'Guessan, Justin Pelletier, Jessie Huang, Carmen Lia Murall, Ahmad Pesaranghader, Vanda Gaonac'h-Lovejoy, David J. Hamelin, Raphaël Poujol, Jean-Christophe Grenier, Martin Smith, Etienne Caron, Morgan Craig, Guy Wolf, Smita Krishnaswamy, B. Jesse Shapiro, Julie G. Hussin
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
The genome of the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), the pathogen that causes coronavirus disease 2019 (COVID-19), has been sequenced at an unprecedented scale leading to a tremendous amount of viral genome sequencing data.
Externí odkaz:
https://doaj.org/article/15d0f0d674344af6963c8d1f5b18412c