Zobrazeno 1 - 10
of 230
pro vyhledávání: '"Smita K. Nair"'
Autor:
Austin M. Eckhoff, Michael C. Brown, Karenia Landa, Ibtehaj Naqvi, Eda K. Holl, David Boczkowski, Ashley Fletcher, Kristen E. Rhodin, Minh Huy Giang, Bruce Sullenger, Georgia M. Beasley, Peter J. Allen, Smita K. Nair
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundMonocytes and monocyte-derived tumor infiltrating cells have been implicated in the immunosuppression and immune evasion associated with pancreatic adenocarcinoma (PDAC). Yet, precisely how monocytes in the periphery and tumor microenvironm
Externí odkaz:
https://doaj.org/article/1eb497b660224ba3b823ad6d334a8bd8
Autor:
Elias O.U. Eteshola, Karenia Landa, Rachel E. Rempel, Ibtehaj A. Naqvi, E. Shelley Hwang, Smita K. Nair, Bruce A. Sullenger
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 26, Iss , Pp 1-10 (2021)
Breast cancer (BC) is the most common malignancy in women. Particular subtypes with aggressive behavior are major contributors to poor outcomes. Triple-negative breast cancer (TNBC) is difficult to treat, pro-inflammatory, and highly metastatic. We d
Externí odkaz:
https://doaj.org/article/525370bc8ac34046ab73baf6e327f0e5
Autor:
Aditya A. Mohan, BSc, Lyra B. Olson, PhD, Ibtehaj A. Naqvi, MD, PhD, Sarah A. Morrison, PhD, Bryan D. Kraft, MD, Lingye Chen, MD, Loretta G. Que, MD, Qing Ma, PhD, Christina E. Barkauskas, MD, Allan Kirk, MD, PhD, Smita K. Nair, PhD, Bruce A. Sullenger, PhD, George Kasotakis, MD, MPH
Publikováno v:
Critical Care Explorations, Vol 4, Iss 12, p e0799 (2022)
OBJECTIVES:. The COVID-19 pandemic has claimed over eight hundred thousand lives in the United States alone, with older individuals and those with comorbidities being at higher risk of severe disease and death. Although severe acute respiratory syndr
Externí odkaz:
https://doaj.org/article/dc9548d080d84b5c94caf1198546cf58
Autor:
Aaron D. Therien, Georgia M. Beasley, Kristen E. Rhodin, Norma E. Farrow, Douglas S. Tyler, David Boczkowski, Rami N. Al-Rohil, Eda K. Holl, Smita K. Nair
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionB cells are key regulators of immune responses in melanoma. We aimed to explore differences in the histologic location and activation status of B cell follicles in sentinel lymph nodes (SLN) of melanoma patients.MethodsFlow cytometry was
Externí odkaz:
https://doaj.org/article/b9f0f4ada7424c5ebc1dcb3d7d1046ae
Autor:
Michael C. Brown, Mubeen M. Mosaheb, Malte Mohme, Zachary P. McKay, Eda K. Holl, Jonathan P. Kastan, Yuanfan Yang, Georgia M. Beasley, E. Shelley Hwang, David M. Ashley, Darell D. Bigner, Smita K. Nair, Matthias Gromeier
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Innate intratumoral immunity might be important in enhancing oncolytic tumor immunotherapy. Here, the authors show that recombinant poliovirus signalling through TBK-IRF3 enhances tumor-infiltrating T cell activity and multi-cytokine function.
Externí odkaz:
https://doaj.org/article/60906122327e4f2e9beced154e87cbb7
Autor:
Matthias Gromeier, Michael C. Brown, Gao Zhang, Xiang Lin, Yeqing Chen, Zhi Wei, Nike Beaubier, Hai Yan, Yiping He, Annick Desjardins, James E. Herndon, Frederick S. Varn, Roel G. Verhaak, Junfei Zhao, Dani P. Bolognesi, Allan H. Friedman, Henry S. Friedman, Frances McSherry, Andrea M. Muscat, Eric S. Lipp, Smita K. Nair, Mustafa Khasraw, Katherine B. Peters, Dina Randazzo, John H. Sampson, Roger E. McLendon, Darell D. Bigner, David M. Ashley
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Recurrent glioblastomas (rGBM) have dismal outcomes, but long-term survival has been observed in subsets of patients after immunotherapy. Here the authors report a positive association between low tumor mutation burden, inflammatory gene signatures,
Externí odkaz:
https://doaj.org/article/9b4f7304b8f54613b5f0b6626698e589
Autor:
Adam M. Swartz, Kendra L. Congdon, Smita K. Nair, Qi-Jing Li, James E. Herndon, Carter M. Suryadevara, Katherine A. Riccione, Gary E. Archer, Pamela K. Norberg, Luis A. Sanchez-Perez, John H. Sampson
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-7 (2021)
Abstract Personalized cancer vaccines targeting neoantigens arising from somatic missense mutations are currently being evaluated for the treatment of various cancers due to their potential to elicit a multivalent, tumor-specific immune response. Sev
Externí odkaz:
https://doaj.org/article/630d5dbd82df4a1bb95d08b2e6228b95
Autor:
Imran Ozer, Garrett Kelly, Renpeng Gu, Xinghai Li, Nikita Zakharov, Parul Sirohi, Smita K. Nair, Joel H. Collier, Michael S. Hershfield, Angus M. Hucknall, Ashutosh Chilkoti
Publikováno v:
Advanced Science, Vol 9, Iss 11, Pp n/a-n/a (2022)
Abstract Protein therapeutics, except for antibodies, have a short plasma half‐life and poor stability in circulation. Covalent coupling of polyethylene glycol (PEG) to protein drugs addresses this limitation. However, unlike previously thought, PE
Externí odkaz:
https://doaj.org/article/25fd6625ae81428db034482f847d8104
Autor:
Mubeen M. Mosaheb, Elena Y. Dobrikova, Michael C. Brown, Yuanfan Yang, Jana Cable, Hideho Okada, Smita K. Nair, Darell D. Bigner, David M. Ashley, Matthias Gromeier
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Experimental PVSRIPO oncolytic virus therapy of glioblastoma has shown long-term efficacy in a subset of patients. Here the authors engineer the virus to enable incorporation of tumor-specific antigens, and show proof-of-principle evidence that this
Externí odkaz:
https://doaj.org/article/9ce93ce8bbd34e53a699a9500f6bbbbf
Autor:
Vidyalakshmi Chandramohan, Xuhui Bao, Xin Yu, Scott Parker, Charlotte McDowall, Yen-Rei Yu, Patrick Healy, Annick Desjardins, Michael D. Gunn, Matthias Gromeier, Smita K. Nair, Ira H. Pastan, Darell D. Bigner
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-14 (2019)
Abstract Background D2C7-IT is a novel immunotoxin (IT) targeting wild-type epidermal growth factor receptor (EGFRwt) and mutant EGFR variant III (EGFRvIII) proteins in glioblastoma. In addition to inherent tumoricidal activity, immunotoxins induce s
Externí odkaz:
https://doaj.org/article/d576966a92ec4a9e8a38ae0eaacdccc4