Association studies suggest a key role for endothelin-1 in the pathogenesis of preeclampsia and the accompanying renin-angiotensin-aldosterone system suppression.

Autor: Verdonk K; From the Division of Vascular Medicine and Pharmacology, Department of Internal Medicine (K.V., L.S., S.L., J.E.I.S., M.M.v.I., I.M.G., E.C.H.F., A.H.v.d.M., A.H.J.D.), Division Obstetrics and Prenatal Medicine, Department of Obstetrics and Gynaecology (W.V.), and Department of Clinical Chemistry (H.R.), Erasmus MC, Rotterdam, The Netherlands., Saleh L; From the Division of Vascular Medicine and Pharmacology, Department of Internal Medicine (K.V., L.S., S.L., J.E.I.S., M.M.v.I., I.M.G., E.C.H.F., A.H.v.d.M., A.H.J.D.), Division Obstetrics and Prenatal Medicine, Department of Obstetrics and Gynaecology (W.V.), and Department of Clinical Chemistry (H.R.), Erasmus MC, Rotterdam, The Netherlands., Lankhorst S; From the Division of Vascular Medicine and Pharmacology, Department of Internal Medicine (K.V., L.S., S.L., J.E.I.S., M.M.v.I., I.M.G., E.C.H.F., A.H.v.d.M., A.H.J.D.), Division Obstetrics and Prenatal Medicine, Department of Obstetrics and Gynaecology (W.V.), and Department of Clinical Chemistry (H.R.), Erasmus MC, Rotterdam, The Netherlands., Smilde JE; From the Division of Vascular Medicine and Pharmacology, Department of Internal Medicine (K.V., L.S., S.L., J.E.I.S., M.M.v.I., I.M.G., E.C.H.F., A.H.v.d.M., A.H.J.D.), Division Obstetrics and Prenatal Medicine, Department of Obstetrics and Gynaecology (W.V.), and Department of Clinical Chemistry (H.R.), Erasmus MC, Rotterdam, The Netherlands., van Ingen MM; From the Division of Vascular Medicine and Pharmacology, Department of Internal Medicine (K.V., L.S., S.L., J.E.I.S., M.M.v.I., I.M.G., E.C.H.F., A.H.v.d.M., A.H.J.D.), Division Obstetrics and Prenatal Medicine, Department of Obstetrics and Gynaecology (W.V.), and Department of Clinical Chemistry (H.R.), Erasmus MC, Rotterdam, The Netherlands., Garrelds IM; From the Division of Vascular Medicine and Pharmacology, Department of Internal Medicine (K.V., L.S., S.L., J.E.I.S., M.M.v.I., I.M.G., E.C.H.F., A.H.v.d.M., A.H.J.D.), Division Obstetrics and Prenatal Medicine, Department of Obstetrics and Gynaecology (W.V.), and Department of Clinical Chemistry (H.R.), Erasmus MC, Rotterdam, The Netherlands., Friesema EC; From the Division of Vascular Medicine and Pharmacology, Department of Internal Medicine (K.V., L.S., S.L., J.E.I.S., M.M.v.I., I.M.G., E.C.H.F., A.H.v.d.M., A.H.J.D.), Division Obstetrics and Prenatal Medicine, Department of Obstetrics and Gynaecology (W.V.), and Department of Clinical Chemistry (H.R.), Erasmus MC, Rotterdam, The Netherlands., Russcher H; From the Division of Vascular Medicine and Pharmacology, Department of Internal Medicine (K.V., L.S., S.L., J.E.I.S., M.M.v.I., I.M.G., E.C.H.F., A.H.v.d.M., A.H.J.D.), Division Obstetrics and Prenatal Medicine, Department of Obstetrics and Gynaecology (W.V.), and Department of Clinical Chemistry (H.R.), Erasmus MC, Rotterdam, The Netherlands., van den Meiracker AH; From the Division of Vascular Medicine and Pharmacology, Department of Internal Medicine (K.V., L.S., S.L., J.E.I.S., M.M.v.I., I.M.G., E.C.H.F., A.H.v.d.M., A.H.J.D.), Division Obstetrics and Prenatal Medicine, Department of Obstetrics and Gynaecology (W.V.), and Department of Clinical Chemistry (H.R.), Erasmus MC, Rotterdam, The Netherlands., Visser W; From the Division of Vascular Medicine and Pharmacology, Department of Internal Medicine (K.V., L.S., S.L., J.E.I.S., M.M.v.I., I.M.G., E.C.H.F., A.H.v.d.M., A.H.J.D.), Division Obstetrics and Prenatal Medicine, Department of Obstetrics and Gynaecology (W.V.), and Department of Clinical Chemistry (H.R.), Erasmus MC, Rotterdam, The Netherlands., Danser AH; From the Division of Vascular Medicine and Pharmacology, Department of Internal Medicine (K.V., L.S., S.L., J.E.I.S., M.M.v.I., I.M.G., E.C.H.F., A.H.v.d.M., A.H.J.D.), Division Obstetrics and Prenatal Medicine, Department of Obstetrics and Gynaecology (W.V.), and Department of Clinical Chemistry (H.R.), Erasmus MC, Rotterdam, The Netherlands. a.danser@erasmusmc.nl.

Publikováno v: Hypertension (Dallas, Tex. : 1979) [Hypertension] 2015 Jun; Vol. 65 (6), pp. 1316-23. Date of Electronic Publication: 2015 Apr 13.