Cardiac protection induced by urocortin-2 enables the regulation of apoptosis and fibrosis after ischemia and reperfusion involving miR-29a modulation

Autor: Mayoral-González, Isabel, Calderón Sánchez, Eva M., Galeano-Otero, Isabel, Martín Bórnez, Marta, Gutiérrez Carretero, Encarnación, Fernández Velasco, María, Ordóñez Fernández, José Antonio, Smani Hajami, Tarik

Urocortin-2 (Ucn-2) has demonstrated cardioprotective ac tions against myocardial ischemia-reperfusion (I/R) injuries. Herein, we explored the protective role of Ucn-2 through microRNAs (miRNAs) post-transcriptional regulation of apoptotic and pro-fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3272::82330dc94f43d4a0c0a8d9a733509212

Melatonin downregulates TRPC6, impairing store-operated calcium entry in triple negative breast cancer cells

Autor: Jardín, Isaac, Díez-Bello, Raquel, Falcón Boyano, Débora, Alvarado, Sandra, Regodón, Sergio, Salido, Gines M., Smani Hajami, Tarik, Rosado, Juan A.

Melatonin has been reported to induce effective reduction in growth and development in a variety of tumors, including breast cancer. In triple-negative breast cancer (TNBC) cells, melatonin attenuates a variety of cancer features, such as tumor growt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3272::83935f2c9b05b9ec5907df5fbc1f9094

Podoplanin Gene Disruption in Mice Promotes in vivo Neural Progenitor Cells Proliferation, Selectively Impairs Dentate Gyrus Synaptic Depression and Induces Anxiety-Like Behaviors

Autor: Cicvaric, Ana, Sachernegg, Hannah M., Stojanovic, Tamara, Symmank, Dörte, Smani Hajami, Tarik, Moeslinger, Thomas, Monje, Francisco J.

Publikováno v: idUS. Depósito de Investigación de la Universidad de Sevilla
instname
idUS: Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)

Podoplanin (Pdpn), a brain-tumor-related glycoprotein identified in humans and animals, is endogenously expressed in several organs critical for life support such as kidney, lung, heart and brain. In the brain, Pdpn has been identified in proliferati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::98ff4edb29ec1ff7876dbc8dec57efce

Urocortin-2 Prevents Dysregulation of Ca2+ Homeostasis and Improves Early Cardiac Remodeling After Ischemia and Reperfusion

Autor: Domínguez Rodríguez, Alejandro, Mayoral-González, Isabel, Ávila Medina, Javier, Sánchez de Rojas de Pedro, Eva, Calderón Sánchez, Eva María, Díaz Carrasco, Ignacio, Hmadcha, Abdelkrim, Castellano Orozco, Antonio Gonzalo, Ordóñez Fernández, Antonio, Smani Hajami, Tarik

Publikováno v: idUS. Depósito de Investigación de la Universidad de Sevilla
instname

Aims: Urocortin-2 (Ucn-2) is a potent cardioprotector against Ischemia and Reperfusion (I/R) injuries. However, little is known about its role in the regulation of intracellular Ca2+ concentration ([Ca2+]i) under I/R. Here, we examined whether the ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::33531b0f88bb80e92780f655a19c523c

Homeostasis del calcio en miocitos del árbol arterial pulmonar

Autor: Smani Hajami, Tarik

Publikováno v: idUS. Depósito de Investigación de la Universidad de Sevilla
instname

La organización histológica arterial se caracteriza por la existencia de tres capas bien definidas. Desde la luz del vaso hacia su exterior, se puede distinguir la capa endotelial cuyas células están generalmente orientas longitudinalmente, segui

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6bfdbd6905e16288c6b848dab6497692
https://idus.us.es/handle/11441/42283