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A consensus yeast metabolic network obtained from a community approach to systems biology

Autor: Herrgard, M.J., Swainston, N., Dobson, P., Dunn, W.B., Arga, K.Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, E.R., Heinemann, M., Hucka, M., Li, P., Liebermeister, W., Mo, M.L., Oliveira, A.P., Petranovic, D., Pettifer, S., Simeonides, E., Smallbone, K., Spasi, I., Weichart, D., Brent, R., Broomhead, D.S., Westerhoff, H.V., Kirdar, B., Penttila, M., Klipp, E., Paton, N., Palsson, B.O., Sauer, U., Oliver, S.G., Mendes, P., Nielsen, J., Kell, D.B.

Publikováno v: Herrgard, M J, Swainston, N, Dobson, P, Dunn, W B, Arga, K Y, Arvas, M, Bluthgen, N, Borger, S, Costenoble, E R, Heinemann, M, Hucka, M, Li, P, Liebermeister, W, Mo, M L, Oliveira, A P, Petranovic, D, Pettifer, S, Simeonides, E, Smallbone, K, Spasi, I, Weichart, D, Brent, R, Broomhead, D S, Westerhoff, H V, Kirdar, B, Penttila, M, Klipp, E, Paton, N, Palsson, B O, Sauer, U, Oliver, S G, Mendes, P, Nielsen, J & Kell, D B 2008, ' A consensus yeast metabolic network obtained from a community approach to systems biology. ', Nature Biotechnology, vol. 26, pp. 1155-1160 . https://doi.org/10.1038/nbt1492
Nature Biotechnology, 26, 1155-1160. Nature Publishing Group

Genomic data allow the large-scale manual or semi-automated assembly of metabolic network reconstructions, which provide highly curated organism-specific knowledge bases. Although several genome-scale network reconstructions describe Saccharomyces ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::105c0c903efa7751f422a332c625af71
https://hdl.handle.net/1871.1/afa00df3-5f6f-431b-b27c-10c5b6d907eb

role of acidity in solid tumour growth and invasion

Autor: Smallbone, K, Gavaghan, D, Gatenby, R, Maini, P

Acidic pH is a common characteristic of human tumours. It has a significant impact on tumour progression and response to therapies. In this paper, we develop a simple model of three-dimensional tumour growth to examine the role of acidosis in the int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::dabc3b7268516a6d4c2ebb36f2a91562
https://ora.ox.ac.uk/objects/uuid:311e7863-5e92-45b9-b108-08010d4d8916

Quiescience as a mechanism for cyclical hypoxia and acidosis

Autor: Smallbone, K, Gavaghan, D, Maini, P, Brady, J

Tumour tissue characteristically experiences fluctuations in substrate supply. This unstable microenvironment drives constitutive metabolic changes within cellular populations and, ultimately, leads to a more aggressive phenotype. Previously, variati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::cc75aa42235f41c9dc26821c199b51c1
https://ora.ox.ac.uk/objects/uuid:12cabaa9-3588-4de4-ba6c-68fd455f791c

Benchmarking methods for computing local sensitivities in ordinary differential equation models at dynamic and steady states.

Autor: Lakrisenko, Polina^1,2 (AUTHOR), Pathirana, Dilan³ (AUTHOR), Weindl, Daniel^1,3 (AUTHOR), Hasenauer, Jan^1,3 (AUTHOR) jan.hasenauer@uni-bonn.de

Publikováno v: PLoS ONE. 10/23/2024, Vol. 19 Issue 10, p1-19. 19p.