Zobrazeno 1 - 10
of 677
pro vyhledávání: '"Small molecule compounds"'
Autor:
Yanling Qu, Zhe Wang, Lingjuan Dong, Dan Zhang, Fengqing Shang, Afeng Li, Yanni Gao, Qinhua Bai, Dan Liu, Xiaodong Xie, Leiguo Ming
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Mesenchymal stem cells (MSCs) therapy is a highly researched treatment that has the potential to promote immunomodulation and anti-inflammatory, anti-apoptotic, and antimicrobial activities. It is thought that it can enhance internal organ f
Externí odkaz:
https://doaj.org/article/3965d1c0601043bdbeba94e2e9ea91fb
Publikováno v:
Jichu yixue yu linchuang, Vol 44, Iss 6, Pp 786-792 (2024)
Objective To optimize the conditions and improve the efficiency for the differentiation of pluripotent stem cells (PSCs) into cerebral organoids. Methods Based on the induction differentiation system for inducing human embryonic stem cells (hESCs) H9
Externí odkaz:
https://doaj.org/article/22f82d4d0f294874bf8f98c4bee4bd11
Publikováno v:
FEBS Open Bio, Vol 14, Iss 6, Pp 983-1000 (2024)
Myocardial infarction results in extensive cardiomyocyte apoptosis, leading to the formation of noncontractile scar tissue. Given the limited regenerative capacity of adult mammalian cardiomyocytes, direct reprogramming of cardiac fibroblasts (CFs) i
Externí odkaz:
https://doaj.org/article/30e4af0215e34f6b8b1455d19ecf909f
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Cuproptosis is a new pattern of Cu-dependent cell death distinct from classic cell death pathways and characterized by aberrant lipoylated protein aggregation in TCA cycle, Fe-S cluster protein loss, HSP70 elevation, proteotoxic and oxidative stress
Externí odkaz:
https://doaj.org/article/fa87886600d24980815000e4d74602fd
Publikováno v:
Pifu-xingbing zhenliaoxue zazhi, Vol 31, Iss 5, Pp 287-296 (2024)
Systemic sclerosis (SSc), as an immune-mediated chronic connective tissue disease, is mainly characterized by fibrosis of multiple organs, including the skin and lungs. It is a rare disease, with a high incidence and mortality among rheumatic immune
Externí odkaz:
https://doaj.org/article/cad171f0f2594c5b9867d4179eb43a4f
Publikováno v:
Annals of Human Biology, Vol 51, Iss 1 (2024)
Background Mitophagy and ferroptosis occur in intracerebral haemorrhage (ICH) but our understanding of mitophagy and ferroptosis-related genes remains incomplete.Aim This study aims to identify shared ICH genes for both processes.Methods ICH differen
Externí odkaz:
https://doaj.org/article/a58a464ef41a481082460e6e0a88d861
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The identification of diagnostic and therapeutic biomarkers for Alzheimer’s Disease (AD) remains a crucial area of research. In this study, utilizing the Weighted Gene Co-expression Network Analysis (WGCNA) algorithm, we identified RHBDF2 and TNFRS
Externí odkaz:
https://doaj.org/article/a2f9e11352ea4b3b9ce5137ce149d1e3
Autor:
Jiaxi Liu, Yongya Wu, Sha Meng, Ping Xu, Shutong Li, Yong Li, Xiuying Hu, Liang Ouyang, Guan Wang
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-30 (2024)
Abstract Eukaryotic cells engage in autophagy, an internal process of self-degradation through lysosomes. Autophagy can be classified as selective or non-selective depending on the way it chooses to degrade substrates. During the process of selective
Externí odkaz:
https://doaj.org/article/b8214b8093164ebca1fd0e1fcd3fe999
Autor:
Di Yang, Xiaoxu Cheng, Meiling Fan, Dong Xie, Zhiqiang Liu, Fei Zheng, Yulin Dai, Zifeng Pi, Hao Yue
Publikováno v:
Chinese Medicine, Vol 19, Iss 1, Pp 1-13 (2024)
Abstract Wu-tou decoction (WTD), a traditional Chinese medicine prescription, is used to treat rheumatoid arthritis (RA). It works by controlling intestinal flora and its metabolites, which in turn modulates the inflammatory response and intestinal b
Externí odkaz:
https://doaj.org/article/5e7e007a2903445490f5a2da1ad081d2
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Triple-negative breast cancer (TNBC) poses a significant clinical challenge due to its propensity for metastasis and poor prognosis. TNBC evades the body’s immune system recognition and attack through various mechanisms, including the Janus Kinase
Externí odkaz:
https://doaj.org/article/a4305bc5d0624eb08b039b04b337a117