Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Small molecule chaperones (SMCs)"'
Autor:
Isabel Cardoso, Márcia A. Liz, Ana Gimeno, Josep Rivas, Ellen Y. Cotrina, Gemma Arsequell, Jordi Llop, Jesús Jiménez-Barbero, José P. Leite, Daniel Blasi, Luis Miguel Santos, Luís Gales, Maria Antònia Busquets, Antoni Planas, Rafel Prohens, Jordi Quintana
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Transthyretin (TTR) has a well-established role in neuroprotection in Alzheimer's Disease (AD). We have setup a drug discovery program of small-molecule compounds that act as chaperones enhancing TTR/Amyloid-beta peptide (Aβ) interactions. A combina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1030e2b5b44fae8a2166ca6577285669
https://pubmed.ncbi.nlm.nih.gov/34555615
https://pubmed.ncbi.nlm.nih.gov/34555615
Autor:
Rafel Prohens, Jordi Quintana, Ellen Y. Cotrina, Gregorio Valencia, Jesús Jiménez-Barbero, Ana Gimeno, Isabel Cardoso, Jordi Llop, Gemma Arsequell
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Journal of Medicinal Chemistry
instname
Journal of Medicinal Chemistry
The plasma protein transthyretin (TTR) modulates Abeta (Aβ) peptides deposition, processing and toxicity. We have shown that this physiological effect is enhanced in mice by treatment with compounds such as iododiflunisal (IDIF) which is a good TTR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9e26892adf4a6d0311ffad0f02df93c
http://hdl.handle.net/10261/233259
http://hdl.handle.net/10261/233259
Akademický článek
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