International union of basic and clinical pharmacology. CVIII. Calcium-sensing receptor nomenclature, pharmacology, and function

Autor: Arthur D. Conigrave, Thor C. Møller, Hans Bräuner-Osborne, Andrew N. Keller, Daniela Riccardi, Katie Leach, Donald T. Ward, Enikö Kállay, Fadil M. Hannan, Rebecca S. Mason, Tracy M. Josephs, Rajesh V. Thakker

Publikováno v: Leach, K, Hannan, F M, Josephs, T M, Keller, A N, Møller, T C, Ward, D T, Kallay, E, Mason, R S, Thakker, R V, Riccardi, D, Conigrave, A D & Bräuner-Osborne, H 2020, ' International Union of Basic and Clinical Pharmacology. CVIII. Calcium-Sensing Receptor Nomenclature, Pharmacology, and Function ', Pharmacological Reviews, vol. 72, no. 3, pp. 558-604 . https://doi.org/10.1124/pr.119.018531
Pharmacological Reviews
Pharmacol Rev

The calcium-sensing receptor (CaSR) is a class C G protein-coupled receptor that responds to multiple endogenous agonists and allosteric modulators, including divalent and trivalent cations, L-amino acids, γ-glutamyl peptides, polyamines, polycation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172ef793c4bcbce0c405d4a538a416f0
https://ora.ox.ac.uk/objects/uuid:36ba0adf-bb2b-4474-a8fa-928bf788b385

A drug discovery platform to identify compounds that inhibit EGFR triple mutants

Autor: Michael Prakesch, Ahmed Aman, Victoria Wong, Leanne E Wybenga-Groot, Michael F. Moran, Nika Vučković, Adrian G. Sacher, Luka Drecun, Miroslav Samaržija, Alessandro Datti, Nhu-An Pham, Zhong Yao, Gennady Poda, Punit Saraon, Marko Jakopović, Babu Joseph, Jenny Wang, Konstantin Weiss, Nikolina Radulovich, Anna Akhmanova, Jin H Park, Adriana Vučetić, Anna Lyakisheva, Ming-Sound Tsao, Ankit Rai, David Uehling, Farzaneh Aboualizadeh, Jamie Snider, Natasha B. Leighl, Frances A. Shepherd, Richard Marcellus, Rima Al-awar, Igor Stagljar, Yannis Kalaidzidis, Brigitte L. Thériault, Marino Zerial, Shivanthy Pathmanathan, Yuhui Wang

Publikováno v: Nature Chemical Biology, 16(5), 577. Nature Publishing Group

Receptor tyrosine kinases (RTKs) are transmembrane receptors of great clinical interest due to their role in disease. Historically, therapeutics targeting RTKs have been identified using in vitro kinase assays. Due to frequent development of drug res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e208d6188be55958239a910d0dd956c1
https://pubmed.ncbi.nlm.nih.gov/32144093

Restoration of mutant bestrophin-1 expression, localisation and function in a polarised epithelial cell model

Autor: Carolina Uggenti, Kit Briant, Anne-Kathrin Streit, Steven Thomson, Yee Hui Koay, Richard A. Baines, Eileithyia Swanton, Forbes D. Manson

Publikováno v: Uggenti, C, Briant, K, Streit, A-K, Thomson, S, Koay, Y H, Baines, R A, Swanton, E & Manson, F D 2016, ' Restoration of mutant bestrophin-1 expression, localisation and function in a polarised epithelial cell model ', Disease Models and Mechanisms, vol. 9, no. 11, pp. 1317-1328 . https://doi.org/10.1242/dmm.024216
Disease Models & Mechanisms
Uggenti, C, Briant, K, Streit, A-K, Thomson, S, Koay, Y H, Baines, R, Swanton, L & Manson, F D 2016, ' Restoration of mutant bestrophin-1 expression, localisation and function in a polarised epithelial cell model ', DMM Disease Models and Mechanisms, vol. 9, no. 11, pp. 1317-1328 . https://doi.org/10.1242/dmm.024216
Disease Models & Mechanisms, Vol 9, Iss 11, Pp 1317-1328 (2016)

Autosomal recessive bestrophinopathy (ARB) is a retinopathy caused by mutations in the bestrophin-1 protein, which is thought to function as a Ca2+-gated Cl− channel in the basolateral surface of the retinal pigment epithelium (RPE). Using a stably

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::239865a4b1663d966fc5181c997e1a95
https://hdl.handle.net/20.500.11820/1cb41380-f9f4-4178-bead-830af72f8a24

Non-invasive phenotyping and drug testing in single cardiomyocytes or beta-cells by calcium imaging and optogenetics

Autor: Takeharu Nagai, Mark J. Davies, Connor N Broyles, Cameron W. Turtle, Matthew J. Daniels, Yu-Fen Chang, F. A. Brook

Publikováno v: Chang, Y-F, Broyles, C N, Brook, F A, Davies, M J, Turtle, C W, Nagai, T & Daniels, M J 2017, ' Non-invasive phenotyping and drug testing in single cardiomyocytes or beta-cells by calcium imaging and optogenetics ', PLoS ONE, vol. 12, no. 4 . https://doi.org/10.1371/journal.pone.0174181
PLoS ONE
PLoS ONE, Vol 12, Iss 4, p e0174181 (2017)

Identification of drug induced electrical instability of the heart curtails development, and introduction, of potentially proarrhythmic drugs. This problem usually requires complimentary contact based approaches such as patch-clamp electrophysiology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f79f258f2a2c3da4e3d4413e47c157c5
https://doi.org/10.1371/journal.pone.0174181

Identification of novel inhibitors of dietary lipid absorption using zebrafish

Autor: Andrew D. Napper, Donna M. Huryn, Michael Pack, Amos B. Smith, Justin D. Clifton, Kotaro Hama, Michael C. Myers, Steven A. Farber, Scott L. Diamond, Edinson Lucumi

Publikováno v: PLoS ONE
PLoS ONE, Vol 5, Iss 8, p e12386 (2010)
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Pharmacological inhibition of dietary lipid absorption induces favorable changes in serum lipoprotein levels in patients that are at risk for cardiovascular disease and is considered an adjuvant or alternative treatment with HMG-CoA reductase inhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a2d730b11ee66c5c98606cd7e82ec3
https://pubmed.ncbi.nlm.nih.gov/20811635