Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Small Interfering/genetics"'
Publikováno v:
Atherosclerosis: Methods and Protocols, 125-132
ISSUE=1;STARTPAGE=125;ENDPAGE=132;TITLE=Atherosclerosis
Methods in Molecular Biology ISBN: 9781071619230
ISSUE=1;STARTPAGE=125;ENDPAGE=132;TITLE=Atherosclerosis
Methods in Molecular Biology ISBN: 9781071619230
Transfection of murine primary macrophages to silence genes can be a challenging procedure because this cell type has developed mechanisms to evade cellular intrusion. The introduction of small interfering RNA (siRNA) encapsulated in liposomes to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd6c5663595e92a5dd74fb2f4ad18374
https://doi.org/10.1007/978-1-0716-1924-7_8
https://doi.org/10.1007/978-1-0716-1924-7_8
Autor:
Eleonora Maurizi, Davide Alessandro Martella, Davide Schiroli, Alessia Merra, Salman Ahmad Mustfa, Graziella Pellegrini, Claudio Macaluso, Ciro Chiappini
Publikováno v:
Maurizi, E, Martella, D A, Schiroli, D, Merra, A, Mustfa, S A, Pellegrini, G, Macaluso, C & Chiappini, C 2022, ' Nanoneedles Induce Targeted siRNA Silencing of p16 in the Human Corneal Endothelium ', Advanced Science, vol. 9, no. 33, pp. e2203257 . https://doi.org/10.1002/advs.202203257
Nanoneedles can target nucleic acid transfection to primary cells at tissue interfaces with high efficiency and minimal perturbation. The corneal endothelium is an ideal target for nanoneedle-mediated RNA interference therapy aimed at enhancing its p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ec97e0e6944563529f6bfe63a9dc68
https://kclpure.kcl.ac.uk/portal/en/publications/nanoneedles-induce-targeted-sirnasilencing-of-p16-in-the-human-corneal-endothelium(c2d75f69-2b16-415e-be54-908a8cba6909).html
https://kclpure.kcl.ac.uk/portal/en/publications/nanoneedles-induce-targeted-sirnasilencing-of-p16-in-the-human-corneal-endothelium(c2d75f69-2b16-415e-be54-908a8cba6909).html
Autor:
Roy Pattipeiluhu, Gabriela Arias‐Alpizar, Genc Basha, Karen Y. T. Chan, Jeroen Bussmann, Thomas H. Sharp, Mohammad‐Amin Moradi, Nico Sommerdijk, Edward N. Harris, Pieter R. Cullis, Alexander Kros, Dominik Witzigmann, Frederick Campbell
Publikováno v:
Advanced Materials, 34
Advanced Materials
Advanced Materials, 34(16):2201095. Wiley-VCH Verlag
Advanced Materials, 34(16):2201095
Advanced Materials, 34, 16
Advanced Materials, 34(16). WILEY-V C H VERLAG GMBH
Advanced Materials
Advanced Materials, 34(16):2201095. Wiley-VCH Verlag
Advanced Materials, 34(16):2201095
Advanced Materials, 34, 16
Advanced Materials, 34(16). WILEY-V C H VERLAG GMBH
Contains fulltext : 282460.pdf (Publisher’s version ) (Open Access) Lipid nanoparticles (LNPs) are the leading nonviral technologies for the delivery of exogenous RNA to target cells in vivo. As systemic delivery platforms, these technologies are e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0a7272d241695a7d0577fea1600c13
http://hdl.handle.net/2066/282460
http://hdl.handle.net/2066/282460
Autor:
Carolien Eggermont, Philippe Giron, Maxim Noeparast, Hugo Vandenplas, Pedro Aza-Blanc, Gustavo J. Gutierrez, Jacques De Grève
Non-small cell lung cancer (NSCLC) patients harboring activating mutations in epidermal growth factor receptor (EGFR) are sensitive to therapy with EGFR tyrosine kinase inhibitors (TKI). Despite remarkable clinical responses using EGFR TKI, surviving
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8d369e1425569db56d294a0d66c876
https://hdl.handle.net/20.500.14017/e1c070ad-96c6-42f6-a7ad-d2c11f334822
https://hdl.handle.net/20.500.14017/e1c070ad-96c6-42f6-a7ad-d2c11f334822
Publikováno v:
Holm, A, Hansen, S N, Klitgaard, H & Kauppinen, S 2022, ' Clinical advances of RNA therapeutics for treatment of neurological and neuromuscular diseases ', RNA Biology, vol. 19, no. 1, pp. 594-608 . https://doi.org/10.1080/15476286.2022.2066334
RNA therapeutics comprise a diverse group of oligonucleotide-based drugs such as antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and short hairpin RNAs (shRNAs) that can be designed to selectively interact with drug targets curren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea210bd5f94a483d8b7e4fb573343f21
https://pubmed.ncbi.nlm.nih.gov/35482908
https://pubmed.ncbi.nlm.nih.gov/35482908
Autor:
Cowell, Alana R, Jacquemet, Guillaume, Singh, Abhimanyu K, Varela, Lorena, Nylund, Anna S, Ammon, York-Christoph, Brown, David G, Akhmanova, Anna, Ivaska, Johanna, Goult, Benjamin T, Sub Cell Biology, Celbiologie
Publikováno v:
The Journal of Cell Biology
Journal of Cell Biology, 220(9). Rockefeller University Press
Journal of Cell Biology, 220(9). Rockefeller University Press
Cowell et al. show that talin rod domain–containing protein 1 (TLNRD1), a protein with homology to the central region of the integrin regulator, talin, has retained the diverse interactions of talin R7R8 but has developed distinct functionality as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b79cfdb097e151a8bbee3796dc610be
http://europepmc.org/articles/PMC8287531
http://europepmc.org/articles/PMC8287531
Autor:
Pei Hsuan Wu, Yu Fu, Phillip D. Zamore, Katharine Cecchini, Cansu Colpan, Amena Arif, Tianxiong Yu, Deniz M. Ozata, Zhiping Weng, Ildar Gainetdinov
Publikováno v:
Nature genetics, Vol. 52, No 7 (2020) pp. 728-739
Pachytene PIWI-interacting RNAs (piRNAs), which comprise >80% of small RNAs in the adult mouse testis, have been proposed to bind and regulate target RNAs like microRNAs, cleave targets like short interfering RNAs or lack biological function altogeth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5e3488b621c481bfc2eae3efe9718cb
https://doi.org/10.1038/s41588-020-0657-7
https://doi.org/10.1038/s41588-020-0657-7
Autor:
Blaise Li, Martino Ugolini, Damarys Loew, Germano Cecere, Aleksei Samolygo, Céline Didier, Eric Cornes, Meetali Singh, Giorgia Barucci, Piergiuseppe Quarato, Florent Dingli
Publikováno v:
Nature cell biology
Nature Cell Biology
Nature Cell Biology, Nature Publishing Group, 2020, 22 (2), pp.235-245. ⟨10.1038/s41556-020-0462-7⟩
Nature Cell Biology, 2020, 22 (2), pp.235-245. ⟨10.1038/s41556-020-0462-7⟩
Nature Cell Biology
Nature Cell Biology, Nature Publishing Group, 2020, 22 (2), pp.235-245. ⟨10.1038/s41556-020-0462-7⟩
Nature Cell Biology, 2020, 22 (2), pp.235-245. ⟨10.1038/s41556-020-0462-7⟩
International audience; PIWI-interacting RNAs (piRNAs) promote fertility in many animals. However, whether this is due to their conserved role in repressing repetitive elements (REs) remains unclear. Here, we show that the progressive loss of fertili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::983b418c96155c11b9d0637d29c2e4f8
https://doi.org/10.1038/s41556-020-0462-7
https://doi.org/10.1038/s41556-020-0462-7
Autor:
Guy Serre, Marie Reynier, Alain Moga, Corinne Leprince, Sophie Allart, Dominique Goudounèche, Michel Simon
Publikováno v:
Journal of Investigative Dermatology
Journal of Investigative Dermatology, Nature Publishing Group, 2019, 139 (7), pp.1430-1438. ⟨10.1016/j.jid.2018.12.021⟩
Journal of Investigative Dermatology, 2019, 139 (7), pp.1430-1438. ⟨10.1016/j.jid.2018.12.021⟩
Journal of Investigative Dermatology, Nature Publishing Group, 2019, 139 (7), pp.1430-1438. ⟨10.1016/j.jid.2018.12.021⟩
Journal of Investigative Dermatology, 2019, 139 (7), pp.1430-1438. ⟨10.1016/j.jid.2018.12.021⟩
International audience; Myosin Vb (Myo5b) is an unconventional myosin involved in the actin-dependent transport and tethering of intracellular organelles. In the epidermis, granular keratinocytes accumulate cytoplasmic lamellar bodies (LBs), secretor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b23279e57f8e5cb9731c489548ae9e
https://doi.org/10.1016/j.jid.2018.12.021
https://doi.org/10.1016/j.jid.2018.12.021
Publikováno v:
Methods in Molecular Biology ISBN: 9781071612972
Holm, A, Løvendorf, M B & Kauppinen, S 2021, Development of siRNA Therapeutics for the Treatment of Liver Diseases . in H J Ditzel, M Tuttolomondo & S Kauppinen (eds), Design and Delivery of SiRNA Therapeutics . vol. 2282, Springer, Methods in Molecular Biology, vol. 2282, pp. 57-75 . https://doi.org/10.1007/978-1-0716-1298-9_5
Holm, A, Løvendorf, M B & Kauppinen, S 2021, Development of siRNA Therapeutics for the Treatment of Liver Diseases . in H J Ditzel, M Tuttolomondo & S Kauppinen (eds), Design and Delivery of SiRNA Therapeutics . vol. 2282, Springer, Methods in Molecular Biology, vol. 2282, pp. 57-75 . https://doi.org/10.1007/978-1-0716-1298-9_5
Small interfering RNA (siRNA)-based therapeutics holds the promise to treat a wide range of human diseases that are currently incurable using conventional therapies. Most siRNA therapeutic efforts to date have focused on the treatment of liver diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc06ebe9e95fa22b68511bde3aef3455
https://doi.org/10.1007/978-1-0716-1298-9_5
https://doi.org/10.1007/978-1-0716-1298-9_5