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FDDNP-PET Tau brain protein binding patterns in military personnel with suspected chronic traumatic encephalopathy

Autor: Chen, ST, Siddarth, P, Merrill, DA, Martinez, J, Emerson, ND, Liu, J, Wong, KP, Satyamurthy, N, Giza, CC, Huang, SC, Fitzsimmons, RP, Bailes, J, Omalu, B, Barrio, JR, Small, GW

Publikováno v: Chen, ST; Siddarth, P; Merrill, DA; Martinez, J; Emerson, ND; Liu, J; et al.(2018). FDDNP-PET Tau brain protein binding patterns in military personnel with suspected chronic traumatic encephalopathy. Journal of Alzheimer's Disease, 65(1), 79-88. doi: 10.3233/JAD-171152. UCLA: Retrieved from: http://www.escholarship.org/uc/item/4qr6b836

© 2018 - IOS Press and the authors. All rights reserved. Background: Our group has shown that in vivo tau brain binding patterns from FDDNP-PET scans in retired professional football players with suspected chronic traumatic encephalopathy differ fro

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Hippocampal thinning linked to longer TOMM40 poly-T variant lengths in the absence of the APOE epsilon 4 variant

Autor: Burggren, AC, Mahmood, Z, Harrison, TM, Siddarth, P, Miller, KJ, Small, GW, Merrill, DA, Bookheimer, SY

Publikováno v: Burggren, AC; Mahmood, Z; Harrison, TM; Siddarth, P; Miller, KJ; Small, GW; et al.(2017). Hippocampal thinning linked to longer TOMM40 poly-T variant lengths in the absence of the APOE epsilon 4 variant. ALZHEIMERS & DEMENTIA, 13(7), 739-748. doi: 10.1016/j.jalz.2016.12.009. UCLA: Retrieved from: http://www.escholarship.org/uc/item/6tj8t16c

The translocase of outer mitochondrial membrane 40 (TOMM40), which lies in linkage disequilibrium with apolipoprotein E (APOE), has received attention more recently as a promising gene in Alzheimer's disease (AD) risk. TOMM40 influences AD pathology

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Neural correlates of apathy in late-life depression: a pilot [F-18]FDDNP positron emission tomography study

Autor: Eyre, HA, Siddarth, P, van Dyk, K, St Cyr, N, Baune, BT, Barrio, JR, Small, GW, Lavretsky, H

Publikováno v: Eyre, HA; Siddarth, P; van Dyk, K; St Cyr, N; Baune, BT; Barrio, JR; et al.(2017). Neural correlates of apathy in late-life depression: a pilot [F-18]FDDNP positron emission tomography study. PSYCHOGERIATRICS, 17(3), 186-193. doi: 10.1111/psyg.12213. UCLA: Retrieved from: http://www.escholarship.org/uc/item/6c2819t4

Neurotoxicity associated with amyloid and tau protein aggregation could represent a pathophysiological cascade that, along with vascular compromise, may predispose individuals to late-life depression (LLD). In LLD, apathy is common, leads to worsenin

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Altered memory-related functional connectivity of the anterior and posterior hippocampus in older adults at increased genetic risk for Alzheimer's disease

Autor: Harrison, TM, Burggren, AC, Small, GW, Bookheimer, SY

Publikováno v: Human brain mapping, vol 37, iss 1
Harrison, TM; Burggren, AC; Small, GW; & Bookheimer, SY. (2016). Altered memory-related functional connectivity of the anterior and posterior hippocampus in older adults at increased genetic risk for Alzheimer's disease. Human Brain Mapping, 37(1), 366-380. doi: 10.1002/hbm.23036. UCLA: Retrieved from: http://www.escholarship.org/uc/item/31t6936d
Human Brain Mapping, vol 37, iss 1
Harrison, TM; Burggren, AC; Small, GW; & Bookheimer, SY. (2015). Altered memory-related functional connectivity of the anterior and posterior hippocampus in older adults at increased genetic risk for Alzheimer's disease. Human Brain Mapping. doi: 10.1002/hbm.23036. UCLA: Retrieved from: http://www.escholarship.org/uc/item/2ks3h0zk

© 2016 Wiley Periodicals, Inc. The hippocampal complex is affected early in Alzheimer's disease (AD). Increasingly, altered functional connectivity of the hippocampus is recognized as an important feature of preclinical AD. Carriers of the APOEeɛ4

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Introduction

Autor: Lavretsky, H, Small, GW

Publikováno v: Lavretsky, H; & Small, GW. (2016). Introduction.. The Journal of clinical psychiatry, 77(1), 116. doi: 10.4088/jcp.15f10522. UCLA: Retrieved from: http://www.escholarship.org/uc/item/9bd358jw

Editor's note: The Focus on Geriatric Psychiatry section is now under the direction of Gary W. Small, MD, and Helen Lavretsky, MD. JCP is indebted to Ipsit Vahia, MD, for his editorial assistance in developing this section. This Focus on Geriatric Ps

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Treating dementia and agitation

Autor: Small, GW

Publikováno v: JAMA, vol 311, iss 7
Small, GW. (2014). Treating dementia and agitation. JAMA-Journal of the American Medical Association, 311(7), 677-678. doi: 10.1001/jama.2014.94. UCLA: Retrieved from: http://www.escholarship.org/uc/item/1p69369b

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