Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Smail Messaoudi"'
Autor:
Basile Gravez, Antoine Tarjus, Ruben Jimenez-Canino, Soumaya El Moghrabi, Smail Messaoudi, Diego Alvarez de la Rosa, Frederic Jaisser
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73737 (2013)
Aldosterone binds to the mineralocorticoid receptor (MR) and exerts pleiotropic effects beyond enhancing renal sodium reabsorption. Excessive mineralocorticoid signaling is deleterious during the evolution of cardiac failure, as evidenced by the bene
Externí odkaz:
https://doaj.org/article/46f7d778118448d9b3b6bfff34848bb0
Autor:
Smail Messaoudi, An Di Zhang, Violaine Griol-Charhbili, Brigitte Escoubet, Junichi Sadoshima, Nicolette Farman, Frederic Jaisser
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30156 (2012)
Experimental and clinical studies have shown that aldosterone/mineralocorticoid receptor (MR) activation has deleterious effects in the cardiovascular system; however, the signalling pathways involved in the pathophysiological effects of aldosterone/
Externí odkaz:
https://doaj.org/article/b89b461687e94da88897642bde4e2bc2
Autor:
Peter Kolkhof, Antoine Ouvrard-Pascaud, Frederic Jaisser, Soumaya El-Moghrabi, Benjamin Bonnard, Paul Mulder, Smail Messaoudi, Marie Pieronne-Deperrois, Zoubir Djerada
Publikováno v:
Journal of Molecular and Cellular Cardiology
Journal of Molecular and Cellular Cardiology, Elsevier, 2018, 121, pp.124-133. ⟨10.1016/j.yjmcc.2018.06.008⟩
Journal of Molecular and Cellular Cardiology, Elsevier, 2018, 121, pp.124-133. ⟨10.1016/j.yjmcc.2018.06.008⟩
Managing the cardiovascular complications of renal failure is a major therapeutic challenge in clinical practice. Mineralocorticoid Receptor (MR) blockade is a highly effective strategy for the management of heart failure, but the use of MR antagonis
Autor:
Frederic Jaisser, Lionel Lattenist, Peter Kolkhof, Jonatan Barrera-Chimal, Smail Messaoudi, Sebastian M. Lechner, Sonia Prince, Soumaya El Moghrabi, Norma A. Bobadilla, Alan Le Mercier
Publikováno v:
Hypertension. 69:870-878
Acute kidney injury induced by ischemia/reperfusion (IR) is a frequent complication in hospitalized patients. Mineralocorticoid receptor antagonism has shown to be helpful against renal IR consequences; however, the potential benefit of novel nonster
Autor:
Patrick Rossignol, Faiez Zannad, Ivan Hernandez-Diaz, Claudine Perret, Soumaya El Moghrabi, Frederic Jaisser, Celine Latouche, Diego Alvarez de la Rosa, Aurelie Nguyen Dinh Cat, Smail Messaoudi, Natalia López Andrés, Nicolette Farman
Publikováno v:
Hypertension. 59:966-972
Mineralocorticoid receptor (MR) activation may be deleterious to the cardiovascular system, and MR antagonists improve morbidity and mortality of patients with heart failure. However, mineralocorticoid signaling in the heart remains largely unknown.
Publikováno v:
Molecular and Cellular Endocrinology. 350:266-272
Several large clinical studies have demonstrated the important benefit of mineralocorticoid receptor (MR) antagonists in patients with heart failure, left ventricular dysfunction after myocardial infarction, hypertension or diabetic nephropathy. Aldo
Autor:
John Chalmers, Mona Nemer, Pavel Hamet, Andrew Wight, Alexandre F.R. Stewart, Rhian M. Touyz, Ying He, Alex Gutsol, Richard L. Hébert, Ruth McPherson, J Tremblay, Andrew P. Makrigiannis, Smail Messaoudi, Ragnar O. Vilmundarson
Publikováno v:
Nature Communications
Despite its high prevalence and economic burden, the aetiology of human hypertension remains incompletely understood. Here we identify the transcription factor GATA5, as a new regulator of blood pressure (BP). GATA5 is expressed in microvascular endo
Autor:
Smail Messaoudi, Frederic Jaisser
Publikováno v:
European Heart Journal Supplements. 13:B4-B9
For decades, the role of aldosterone was thought to be limited to salt and water homeostasis control. This traditional view of the action of aldosterone restricted to sodium reabsorption in epithelial tissues must be revisited. Clinical trials have d
Publikováno v:
The FASEB Journal. 23:2176-2185
Recent reports showed an unexpected worsening of endothelial function by aldosterone antagonism in diabetic patients, suggesting that aldosterone could interfere with the detrimental consequences of diabetes on microvasculature and thus on cardiac fu
Autor:
Iris Schuster, Smail Messaoudi, Elke Dworatzek, Frederic Jaisser, Ingo Morano, Vera Regitz-Zagrosek, Shokoufeh Mahmoodzadeh
Publikováno v:
Clinical Science
Clinical Science, 2016, 130 (5), pp.365-376. ⟨10.1042/CS20150609⟩
Clinical Science, Portland Press, 2016, 130 (5), pp.365-376. ⟨10.1042/CS20150609⟩
Clinical Science, 2016, 130 (5), pp.365-376. ⟨10.1042/CS20150609⟩
Clinical Science, Portland Press, 2016, 130 (5), pp.365-376. ⟨10.1042/CS20150609⟩
International audience; ERβ (oestrogen receptor β) activation has been shown to be cardioprotective, but the cell types and mechanisms involved are not understood. To investigate whether ERβ restricted to cardiomyocytes contributes to the observed