Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Smadar Cohen-Chalamish"'
Autor:
K. Shanmugha Rajan, Saurav Aryal, Disha-Gajanan Hiregange, Anat Bashan, Hava Madmoni, Mika Olami, Tirza Doniger, Smadar Cohen-Chalamish, Pascal Pescher, Masato Taoka, Yuko Nobe, Aliza Fedorenko, Tanaya Bose, Ella Zimermann, Eric Prina, Noa Aharon-Hefetz, Yitzhak Pilpel, Toshiaki Isobe, Ron Unger, Gerald F. Späth, Ada Yonath, Shulamit Michaeli
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114203- (2024)
Summary: Leishmania is the causative agent of cutaneous and visceral diseases affecting millions of individuals worldwide. Pseudouridine (Ψ), the most abundant modification on rRNA, changes during the parasite life cycle. Alterations in the level of
Externí odkaz:
https://doaj.org/article/1af39d1e364149228194dd16b1cc4963
Autor:
K. Shanmugha Rajan, Hava Madmoni, Anat Bashan, Masato Taoka, Saurav Aryal, Yuko Nobe, Tirza Doniger, Beathrice Galili Kostin, Amit Blumberg, Smadar Cohen-Chalamish, Schraga Schwartz, Andre Rivalta, Ella Zimmerman, Ron Unger, Toshiaki Isobe, Ada Yonath, Shulamit Michaeli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Trypanosomes are protozoan parasites that cycle between insect and mammalian hosts and are the causative agent of sleeping sickness. Here, we describe the changes of pseudouridine (Ψ) modification on rRNA in the two life stages of the paras
Externí odkaz:
https://doaj.org/article/13fe9a6c17164bf5b6d6496ccbcea44a
Autor:
Laura Piel, K Shanmugha Rajan, Giovanni Bussotti, Hugo Varet, Rachel Legendre, Caroline Proux, Thibaut Douché, Quentin Giai-Gianetto, Thibault Chaze, Thomas Cokelaer, Barbora Vojtkova, Nadav Gordon-Bar, Tirza Doniger, Smadar Cohen-Chalamish, Praveenkumar Rengaraj, Céline Besse, Anne Boland, Jovana Sadlova, Jean-François Deleuze, Mariette Matondo, Ron Unger, Petr Volf, Shulamit Michaeli, Pascale Pescher, Gerald F Späth
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010375 (2022)
The protozoan parasite Leishmania donovani causes fatal human visceral leishmaniasis in absence of treatment. Genome instability has been recognized as a driver in Leishmania fitness gain in response to environmental change or chemotherapy. How genom
Externí odkaz:
https://doaj.org/article/6054875378b740aabcc0a4e834d05c3b
Autor:
Nofar Atari, K. Shanmugha Rajan, Vaibhav Chikne, Smadar Cohen-Chalamish, Tirza Doniger, Odelia Orbaum, Avi Jacob, Inna Kalt, Shulamit Michaeli, Ronit Sarid
Publikováno v:
Viruses, Vol 14, Iss 8, p 1720 (2022)
The nucleolus is a subnuclear compartment whose primary function is the biogenesis of ribosomal subunits. Certain viral infections affect the morphology and composition of the nucleolar compartment and influence ribosomal RNA (rRNA) transcription and
Externí odkaz:
https://doaj.org/article/8b4fc7ddcdbe421eb177c9e1f7f42875
Autor:
K. Shanmugha Rajan, Tirza Doniger, Smadar Cohen-Chalamish, Praveenkumar Rengaraj, Beathrice Galili, Saurav Aryal, Ron Unger, Christian Tschudi, Shulamit Michaeli
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101780- (2020)
Summary: The parasite Trypanosoma brucei is the causative agent of sleeping sickness and cycles between insect and mammalian hosts. The parasite appears to lack conventional transcriptional regulation of protein coding genes, and mRNAs are processed
Externí odkaz:
https://doaj.org/article/b8f8d1d70af44267a3c3b433bf2669b0
Publikováno v:
PeerJ, Vol 7, p e7608 (2019)
It is assumed that the sequencing of ribosomes better reflects the active microbial community than the sequencing of the ribosomal RNA encoding genes. Yet, many studies exploring microbial communities in various environments, ranging from the human g
Externí odkaz:
https://doaj.org/article/4419680ad0b34404bea37ac0cf17e72e
Autor:
Raymond Kaempfer, Lena Ilan, Smadar Cohen-Chalamish, Orli Turgeman, Lise Sarah Namer, Farhat Osman
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
A critical step in the cellular stress response is transient activation of the RNA-dependent protein kinase PKR by double-helical RNA, resulting in down-regulation of protein synthesis through phosphorylation of the α chain of translation initiation
Externí odkaz:
https://doaj.org/article/64d3508dcf124420accf8e6bb274fa61
Autor:
Dror Eliaz, Sriram Kannan, Hadassa Shaked, Gil Arvatz, Itai Dov Tkacz, Lior Binder, Hiba Waldman Ben-Asher, Uthman Okalang, Vaibhav Chikne, Smadar Cohen-Chalamish, Shulamit Michaeli
Publikováno v:
PLoS Pathogens, Vol 13, Iss 3, p e1006245 (2017)
Extracellular vesicles (EV) secreted by pathogens function in a variety of biological processes. Here, we demonstrate that in the protozoan parasite Trypanosoma brucei, exosome secretion is induced by stress that affects trans-splicing. Following per
Externí odkaz:
https://doaj.org/article/6d5be7b6dfff4aee9b63fbe6eef425a2
Autor:
Fabien Guegan, K. Shanmugha Rajan, Fábio Bento, Daniel Pinto-Neves, Mariana Sequeira, Natalia Gumińska, Seweryn Mroczek, Andrzej Dziembowski, Smadar Cohen-Chalamish, Tirza Doniger, Beathrice Galili, Antonio M. Estévez, Cedric Notredame, Shulamit Michaeli, Luisa M. Figueiredo
Publikováno v:
Science advances. 8(24)
Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY
Autor:
Gordon G. Carmichael, Ron Unger, Yinzhou Zhu, K. Shanmugha Rajan, Moran Shalev-Benami, Smadar Cohen-Chalamish, Katerina Adler, Tirza Doniger, Christian Tschudi, Arthur Günzl, Shulamit Michaeli, Donna Matzov, Ankita Srivastava
Publikováno v:
RNA Biol
The parasite Trypanosoma brucei cycles between insect and mammalian hosts, and is the causative agent of sleeping sickness. Here, we performed genome-wide mapping of 2ʹ-O-methylations (Nms) on trypanosome rRNA using three high-throughput sequencing