A first update on mapping the human genetic architecture of COVID-19

Autor: COVID-19 Host Genetics Initiative, Pathak, GA, Karjalainen, J, Stevens, C, Neale, BM, Daly, M, Ganna, A, Andrews, SJ, Kanai, M, Cordioli, M, Polimanti, R, Harerimana, N, Pirinen, M, Liao, RG, Chwialkowska, K, Trankiem, A, Balaconis, MK, Nguyen, H, Solomonson, M, Veerapen, K, Wolford, B, Roberts, G, Park, D, Ball, CA, Coignet, M, McCurdy, S, Knight, S, Partha, R, Rhead, B, Zhang, M, Berkowitz, N, Gaddis, M, Noto, K, Ruiz, L, Pavlovic, M, Hong, EL, Rand, K, Girshick, A, Guturu, H, Baltzell, AH, Niemi, MEK, Rahmouni, S, Guntz, J, Beguin, Y, Pigazzini, S, Nkambule, L, Georges, M, Moutschen, M, Misset, B, Darcis, G, Guiot, J, Azarzar, S, Gofflot, S, Claassen, S, Malaise, O, Huynen, P, Meuris, C, Thys, M, Jacques, J, Leonard, P, Frippiat, F, Giot, J-B, Sauvage, A-S, Frenckell, CV, Belhaj, Y, Lambermont, B, Nakanishi, T, Morrison, DR, Mooser, V, Richards, JB, Butler-Laporte, G, Forgetta, V, Li, R, Ghosh, B, Laurent, L, Belisle, A, Henry, D, Abdullah, T, Adeleye, O, Mamlouk, N, Kimchi, N, Afrasiabi, Z, Rezk, N, Vulesevic, B, Bouab, M, Guzman, C, Petitjean, L, Tselios, C, Xue, X, Afilalo, J, Afilalo, M, Oliveira, M, Brenner, B, Brassard, N, Durand, M, Schurr, E, Lepage, P, Ragoussis, J, Auld, D, Chassé, M, Kaufmann, DE, Lathrop, GM, Adra, D, Hayward, C, Glessner, JT, Shaw, DM, Campbell, A, Morris, M, Hakonarson, H, Porteous, DJ, Below, J, Richmond, A, Chang, X, Polikowski, H, Lauren, PE, Chen, H-H, Wanying, Z, Fawns-Ritchie, C, North, K, McCormick, JB, Glessner, JR, Gignoux, CR, Wicks, SJ, Crooks, K, Barnes, KC, Daya, M, Shortt, J, Rafaels, N, Chavan, S, Timmers, PRHJ, Wilson, JF, Tenesa, A, Kerr, SM, D’Mellow, K, Shahin, D, El-Sherbiny, YM, von Hohenstaufen, KA, Sobh, A, Eltoukhy, MM, Nkambul, L, Elhadidy, TA, Abd Elghafar, MS, El-Jawhari, JJ, Mohamed, AAS, Elnagdy, MH, Samir, A, Abdel-Aziz, M, Khafaga, WT, El-Lawaty, WM, Torky, MS, El-shanshory, MR, Yassen, AM, Hegazy, MAF, Okasha, K, Eid, MA, Moahmed, HS, Medina-Gomez, C, Ikram, MA, Uitterlinden, AG, Mägi, R, Milani, L, Metspalu, A, Laisk, T, Läll, K, Lepamets, M, Esko, T, Reimann, E, Naaber, P, Laane, E, Pesukova, J, Peterson, P, Kisand, K, Tabri, J, Allos, R, Hensen, K, Starkopf, J, Ringmets, I, Tamm, A, Kallaste, A, Alavere, H, Metsalu, K, Puusepp, M, Batini, C, Tobin, MD, Venn, LD, Lee, PH, Shrine, N, Williams, AT, Guyatt, AL, John, C, Packer, RJ, Ali, A, Free, RC, Wang, X, Wain, LV, Hollox, EJ, Bee, CE, Adams, EL, Palotie, A, Ripatti, S, Ruotsalainen, S, Kristiansson, K, Koskelainen, S, Perola, M, Donner, K, Kivinen, K, Kaunisto, M, Rivolta, C, Bochud, P-Y, Bibert, S, Boillat, N, Nussle, SG, Albrich, W, Quinodoz, M, Kamdar, D, Suh, N, Neofytos, D, Erard, V, Voide, C, Friolet, R, Vollenweider, P, Pagani, JL, Oddo, M, zu Bentrup, FM, Conen, A, Clerc, O, Marchetti, O, Guillet, A, Guyat-Jacques, C, Foucras, S, Rime, M, Chassot, J, Jaquet, M, Viollet, RM, Lannepoudenx, Y, Portopena, L, Bochud, PY, Desgranges, F, Filippidis, P, Guéry, B, Haefliger, D, Kampouri, EE, Manuel, O, Munting, A, Papadimitriou-Olivgeris, M, Regina, J, Rochat-Stettler, L, Suttels, V, Tadini, E, Tschopp, J, Van Singer, M, Viala, B, Boillat-Blanco, N, Brahier, T, Hügli, O, Meuwly, JY, Pantet, O, Gonseth Nussle, S, Bochud, M, D’Acremont, V, Estoppey Younes, S, Albrich, WC, Cerny, A, O’Mahony, L, von Mering, C, Frischknecht, M, Kleger, G-R., Filipovic, M, Kahlert, CR, Wozniak, H, Negro, TR, Pugin, J, Bouras, K, Knapp, C, Egger, T, Perret, A, Montillier, P, di Bartolomeo, C, Barda, B, de Cid, R, Carreras, A, Moreno, V, Kogevinas, M, Galván-Femenía, I, Blay, N, Farré, X, Sumoy, L, Cortés, B, Mercader, JM, Guindo-Martinez, M, Torrents, D, Garcia-Aymerich, J, Castaño-Vinyals, G, Dobaño, C, Gori, M, Renieri, A, Mari, F, Mondelli, MU, Castelli, F, Vaghi, M, Rusconi, S, Montagnani, F, Bargagli, E, Franchi, F, Mazzei, MA, Cantarini, L, Tacconi, D, Feri, M, Scala, R, Spargi, G, Nencioni, C, Bandini, M, Caldarelli, GP, Canaccini, A, Ognibene, A, D’Arminio Monforte, A, Girardis, M, Antinori, A, Francisci, D, Schiaroli, E, Scotton, PG, Panese, S, Scaggiante, R, Monica, MD, Capasso, M, Fiorentino, G, Castori, M, Aucella, F, Biagio, AD, Masucci, L, Valente, S, Mandalà, M, Zucchi, P, Giannattasio, F, Coviello, DA, Mussini, C, Tavecchia, L, Crotti, L, Rizzi, M, Rovere, MTL, Sarzi-Braga, S, Bussotti, M, Ravaglia, S, Artuso, R, Perrella, A, Romani, D, Bergomi, P, Catena, E, Vincenti, A, Ferri, C, Grassi, D, Pessina, G, Tumbarello, M, Pietro, MD, Sabrina, R, Luchi, S, Furini, S, Dei, S, Benetti, E, Picchiotti, N, Sanarico, M, Ceri, S, Pinoli, P, Raimondi, F, Biscarini, F, Stella, A, Zguro, K, Capitani, K, Tanfoni, M, Fallerini, C, Daga, S, Baldassarri, M, Fava, F, Frullanti, E, Valentino, F, Doddato, G, Giliberti, A, Tita, R, Amitrano, S, Bruttini, M, Croci, S, Meloni, I, Mencarelli, MA, Rizzo, CL, Pinto, AM, Beligni, G, Tommasi, A, Sarno, LD, Palmieri, M, Carriero, ML, Alaverdian, D, Busani, S, Bruno, R, Vecchia, M, Belli, MA, Mantovani, S, Ludovisi, S, Quiros-Roldan, E, Antoni, MD, Zanella, I, Siano, M, Emiliozzi, A, Fabbiani, M, Rossetti, B, Bergantini, L, D’Alessandro, M, Cameli, P, Bennett, D, Anedda, F, Marcantonio, S, Scolletta, S, Guerrini, S, Conticini, E, Frediani, B, Spertilli, C, Donati, A, Guidelli, L, Corridi, M, Croci, L, Piacentini, P, Desanctis, E, Cappelli, S, Verzuri, A, Anemoli, V, Pancrazzi, A, Lorubbio, M, Miraglia, FG, Venturelli, S, Cossarizza, A, Vergori, A, Gabrieli, A, Riva, A, Paciosi, F, Andretta, F, Gatti, F, Parisi, SG, Baratti, S, Piscopo, C, Russo, R, Andolfo, I, Iolascon, A, Carella, M, Merla, G, Squeo, GM, Raggi, P, Marciano, C, Perna, R, Bassetti, M, Sanguinetti, M, Giorli, A, Salerni, L, Parravicini, P, Menatti, E, Trotta, T, Coiro, G, Lena, F, Martinelli, E, Mancarella, S, Gabbi, C, Maggiolo, F, Ripamonti, D, Bachetti, T, Suardi, C, Parati, G, Bottà, G, Domenico, PD, Rancan, I, Bianchi, F, Colombo, R, Barbieri, C, Acquilini, D, Andreucci, E, Segala, FV, Tiseo, G, Falcone, M, Lista, M, Poscente, M, Vivo, OD, Petrocelli, P, Guarnaccia, A, Baroni, S, van Heel, DA, Hunt, KA, Trembath, RC, Huang, QQ, Martin, HC, Mason, D, Trivedi, B, Wright, J, Finer, S, Akhtar, S, Anwar, M, Arciero, E, Ashraf, S, Breen, G, Chung, R, Curtis, CJ, Chowdhury, M, Colligan, G, Deloukas, P, Durham, C, Griffiths, C, Hurles, M, Hussain, S, Islam, K, Khan, A, Lavery, C, Lee, SH, Lerner, R, MacArthur, D, MacLaughlin, B, Martin, H, Miah, S, Newman, B, Safa, N, Tahmasebi, F, Griffiths, CJ, Smith, AV, Boughton, AP, Li, KW, LeFaive, J, Annis, A, Niavarani, A, Aliannejad, R, Sharififard, B, Amirsavadkouhi, A, Naderpour, Z, Tadi, HA, Aleagha, AE, Ahmadi, S, Moghaddam, SBM, Adamsara, A, Saeedi, M, Abdollahi, H, Hosseini, A, Chariyavilaskul, P, Jantarabenjakul, W, Hirankarn, N, Chamnanphon, M, Suttichet, TB, Shotelersuk, V, Pongpanich, M, Phokaew, C, Chetruengchai, W, Putchareon, O, Torvorapanit, P, Puthanakit, T, Suchartlikitwong, P, Nilaratanakul, V, Sodsai, P, Brumpton, BM, Hveem, K, Willer, C, Zhou, W, Rogne, T, Solligard, E, Åsvold, BO, Franke, L, Boezen, M, Deelen, P, Claringbould, A, Lopera, E, Warmerdam, R, Vonk, JM, van Blokland, I, Lanting, P, Ori, APS, Feng, Y-CA, Mercader, J, Weiss, ST, Karlson, EW, Smoller, JW, Murphy, SN, Meigs, JB, Woolley, AE, Green, RC, Perez, EF, Zöllner, S, Wang, J, Beck, A, Sloofman, LG, Ascolillo, S, Sebra, RP, Collins, BL, Levy, T, Buxbaum, JD, Sealfon, SC, Jordan, DM, Thompson, RC, Gettler, K, Chaudhary, K, Belbin, GM, Preuss, M, Hoggart, C, Choi, S, Underwood, SJ, Salib, I, Britvan, B, Keller, K, Tang, L, Peruggia, M, Hiester, LL, Niblo, K, Aksentijevich, A, Labkowsky, A, Karp, A, Zlatopolsky, M, Zyndorf, M, Charney, AW, Beckmann, ND, Schadt, EE, Abul-Husn, NS, Cho, JH, Itan, Y, Kenny, EE, Loos, RJF, Nadkarni, GN, Do, R, O’Reilly, P, Huckins, LM, Ferreira, MAR, Abecasis, GR, Leader, JB, Cantor, MN, Justice, AE, Carey, DJ, Chittoor, G, Josyula, NS, Kosmicki, JA, Horowitz, JE, Baras, A, Gass, MC, Yadav, A, Mirshahi, T, Hottenga, JJ, Bartels, M, de geus, EEJC, Nivard, MMG, Verma, A, Ritchie, MD, Rader, D, Li, B, Verma, SS, Lucas, A, Bradford, Y, Abedalthagafi, M, Alaamery, M, Alshareef, A, Sawaji, M, Massadeh, S, AlMalik, A, Alqahtani, S, Baraka, D, Harthi, FA, Alsolm, E, Safieh, LA, Alowayn, AM, Alqubaishi, F, Mutairi, AA, Mangul, S, Almutairi, M, Aljawini, N, Albesher, N, Arabi, YM, Mahmoud, ES, Khattab, AK, Halawani, RT, Alahmadey, ZZ, Albakri, JK, Felemban, WA, Suliman, BA, Hasanato, R, Al-Awdah, L, Alghamdi, J, AlZahrani, D, AlJohani, S, Al-Afghani, H, AlDhawi, N, AlBardis, H, Alkwai, S, Alswailm, M, Almalki, F, Albeladi, M, Almohammed, I, Barhoush, E, Albader, A, Alotaibi, S, Alghamdi, B, Jung, J, fawzy, MS, Alrashed, M, Zeberg, H, Frithiof, R, Hultström, M, Lipcsey, M, Tardif, N, Rooyackers, O, Grip, J, Maricic, T, Helgeland, Ø, Magnus, P, Trogstad, L-IS, Lee, Y, Harris, JR, Mangino, M, Spector, TD, Emma, D, Moutsianas, L, Caulfield, MJ, Scott, RH, Kousathanas, A, Pasko, D, Walker, S, Stuckey, A, Odhams, CA, Rhodes, D, Fowler, T, Rendon, A, Chan, G, Arumugam, P, Karczewski, KJ, Martin, AR, Wilson, DJ, Spencer, CCA, Crook, DW, Wyllie, DH, O’Connell, AM, Atkinson, EG, Tsuo, K, Baya, N, Turley, P, Gupta, R, Walters, RK, Palmer, DS, Sarma, G, Cheng, N, Lu, W, Churchhouse, C, Goldstein, JI, King, D, Seed, C, Daly, MJ, Finucane, H, Bryant, S, Satterstrom, FK, Band, G, Earle, SG, Lin, S-K, Arning, N, Koelling, N, Armstrong, J, Rudkin, JK, Callier, S, Cusick, C, Soranzo, N, Zhao, JH, Danesh, J, Angelantonio, ED, Butterworth, AS, Sun, YV, Huffman, JE, Cho, K, O’Donnell, CJ, Tsao, P, Gaziano, JM, Peloso, G, Ho, Y-L, Smieszek, SP, Polymeropoulos, C, Polymeropoulos, V, Polymeropoulos, MH, Przychodzen, BP, Fernandez-Cadenas, I, Planas, AM, Perez-Tur, J, Llucià-Carol, L, Cullell, N, Muiño, E, Cárcel-Márquez, J, DeDiego, ML, Iglesias, LL, Soriano, A, Rico, V, Agüero, D, Bedini, JL, Lozano, F, Domingo, C, Robles, V, Ruiz-Jaén, F, Márquez, L, Gomez, J, Coto, E, Albaiceta, GM, García-Clemente, M, Dalmau, D, Arranz, MJ, Dietl, B, Serra-Llovich, A, Soler, P, Colobrán, R, Martín-Nalda, A, Martínez, AP, Bernardo, D, Rojo, S, Fiz-López, A, Arribas, E, de la Cal-Sabater, P, Segura, T, González-Villa, E, Serrano-Heras, G, Martí-Fàbregas, J, Jiménez-Xarrié, E, de Felipe Mimbrera, A, Masjuan, J, García-Madrona, S, Domínguez-Mayoral, A, Villalonga, JM, Menéndez-Valladares, P, Chasman, DI, Sesso, HD, Manson, JE, Buring, JE, Ridker, PM, Franco, G, Davis, L, Lee, S, Priest, J, Sankaran, VG, van Heel, D, Biesecker, L, Kerchberger, VE, Baillie, JK

Publikováno v: Nature, 608(7921), E1-E10. Nature Publishing Group
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COVID-19 Host Genetics Initiative, Hottenga, J J, Bartels, M, de Geus, E J C & Nivard, M 2022, ' A first update on mapping the human genetic architecture of COVID-19 ', Nature, vol. 608, no. 7921, pp. E1-E10 . https://doi.org/10.1038/s41586-022-04826-7
2022, ' A first update on mapping the human genetic architecture of COVID-19 ', Nature, vol. 608, no. 7921, pp. E1-E10 . https://doi.org/10.1038/s41586-022-04826-7

Matters arising from: Mapping the human genetic architecture of COVID-19 Original Article published on 08 July 2021 https://www.nature.com/articles/s41586-021-03767-x The COVID-19 pandemic continues to pose a major public health threat, especially in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827cbe7f6ea8d3fe660425d3d9cc06f9
https://doi.org/10.1038/s41586-022-04826-7

Proximity analysis of native proteomes reveals phenotypic modifiers in a mouse model of autism and related neurodevelopmental conditions.

Autor: Gao Y; Department of Cell Biology, Duke University School of Medicine, Durham, NC, USA.; Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA., Shonai D; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA., Trn M; Department of Cell Biology, Duke University School of Medicine, Durham, NC, USA., Zhao J; Department of Biology, Duke University, Durham, NC, USA., Soderblom EJ; Department of Cell Biology, Duke University School of Medicine, Durham, NC, USA.; Proteomics and Metabolomics Shared Resource, Duke University School of Medicine, Durham, NC, USA., Garcia-Moreno SA; Department of Biomedical Engineering, Duke University, Durham, NC, USA., Gersbach CA; Department of Cell Biology, Duke University School of Medicine, Durham, NC, USA.; Department of Biomedical Engineering, Duke University, Durham, NC, USA.; Center for Advanced Genomic Technologies, Duke University, Durham, NC, USA.; Department of Surgery, Duke University Medical Center, Durham, NC, USA., Wetsel WC; Department of Cell Biology, Duke University School of Medicine, Durham, NC, USA.; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA.; Department of Neurobiology, Duke University School of Medicine, Durham, NC, USA.; Mouse Behavioral and Neuroendocrine Analysis Core Facility, Duke University School of Medicine, Durham, NC, USA., Dawson G; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA., Velmeshev D; Department of Neurobiology, Duke University School of Medicine, Durham, NC, USA., Jiang YH; Department of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA.; Department of Neuroscience, Yale University School of Medicine, New Haven, Connecticut, USA.; Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA., Sloofman LG; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Buxbaum JD; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Soderling SH; Department of Cell Biology, Duke University School of Medicine, Durham, NC, USA. Scott.Soderling@duke.edu.; Department of Neurobiology, Duke University School of Medicine, Durham, NC, USA. Scott.Soderling@duke.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Aug 09; Vol. 15 (1), pp. 6801. Date of Electronic Publication: 2024 Aug 09.

Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative.

Autor: Butler-Laporte G; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Québec, Canada.; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada., Povysil G; Institute for Genomic Medicine, Columbia University, New York city, New York, United States of America., Kosmicki JA; Regeneron Genetics Center, Tarrytown, New York, United States of America., Cirulli ET; Helix, San Mateo, California, United States of America., Drivas T; Division of Human Genetics, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.; Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Furini S; Department of Medical Biotechnologies, Med Biotech Hub and Competence Center, University of Siena, Siena, Italy., Saad C; Qatar Genome Program, Qatar Foundation Research, Development and Innovation, Qatar Foundation, Doha, Qatar., Schmidt A; Institute of Human Genetics, School of Medicine and University Hospital Bonn, University of Bonn, Bonn, Germany., Olszewski P; IMAGENE.ME SA, Bialystok, Poland., Korotko U; IMAGENE.ME SA, Bialystok, Poland.; Centre for Bioinformatics and Data Analysis, Medical University of Bialystok, Bialystok, Poland., Quinodoz M; Institute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, Switzerland.; Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom.; Department of Ophthalmology, University Hospital Basel, Basel, Switzerland., Çelik E; Institute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, Switzerland.; Department of Ophthalmology, University Hospital Basel, Basel, Switzerland., Kundu K; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, United Kingdom., Walter K; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, United Kingdom., Jung J; Department of Clinical Pharmacy, School of Pharmacy, University of Southern California, Los Angeles, California, United States of America.; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America., Stockwell AD; Genentech Inc, South San Francisco, California, United States of America., Sloofman LG; Seaver Autism Center for Research and Treatment, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York city, New York, United States of America., Jordan DM; Mount Sinai Clnical Intelligence Center, Charles Bronfman Institute for Personalized Medicine, Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York city, New York, United States of America., Thompson RC; Icahn Institute of Data Science and Genomics Technology, New York city, New York, United States of America., Del Valle D; Icahn School of Medicine at Mount Sinai, New York city, New York, United States of America., Simons N; Icahn School of Medicine at Mount Sinai, New York city, New York, United States of America., Cheng E; Icahn School of Medicine at Mount Sinai, New York city, New York, United States of America., Sebra R; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York city,New York, United States of America., Schadt EE; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York city,New York, United States of America., Kim-Schulze S; Department of Oncological Science, Human Immune Monitoring Center, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York city, New York, United States of America., Gnjatic S; Icahn School of Medicine at Mount Sinai, New York city, New York, United States of America., Merad M; Precision Immunology Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York city, New York, United States of America., Buxbaum JD; Seaver Autism Center for Research and Treatment, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York city, New York, United States of America., Beckmann ND; Precision Immunology Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York city, New York, United States of America., Charney AW; Mount Sinai Clinical Intelligence Center; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York city, New York, United States of America., Przychodzen B; Vanda Pharmaceuticals, Washington, District of Columbia, United States of America., Chang T; Department of Neurology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, United States of America., Pottinger TD; Institute for Genomic Medicine, Columbia University, New York city, New York, United States of America., Shang N; Division of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York city, New York, United States of America., Brand F; Institute of Genomic Statistics and Bioinformatics, School of Medicine and University Hospital Bonn, University of Bonn, Bonn, Germany., Fava F; Department of Medical Biotechnologies, Med Biotech Hub and Competence Center, University of Siena, Siena, Italy.; Genetica Medica, Azienda Ospedaliero-Universitaria Senese, Siena, Italy.; Medical Genetics, University of Siena, Siena, Italy., Mari F; Department of Medical Biotechnologies, Med Biotech Hub and Competence Center, University of Siena, Siena, Italy.; Genetica Medica, Azienda Ospedaliero-Universitaria Senese, Siena, Italy.; Medical Genetics, University of Siena, Siena, Italy., Chwialkowska K; IMAGENE.ME SA, Bialystok, Poland.; Centre for Bioinformatics and Data Analysis, Medical University of Bialystok, Bialystok, Poland., Niemira M; Centre for Clinical Research, Medical University of Bialystok, Bialystok, Poland., Pula S; IMAGENE.ME SA, Bialystok, Poland., Baillie JK; Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom.; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.; Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.; Intensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom., Stuckey A; Genomics England, London, United Kingdom., Salas A; Unidade de Xenética, Instituto de Ciencias Forenses (INCIFOR), Facultade de Medicina, Universidade de Santiago de Compostela, and GenPoB Research Group, Instituto de Investigaciones Sanitarias, Hospital Clínico Universitario de Santiago (SERGAS), Santiago de Compostela, Galicia, Spain.; Genetics, Vaccines and Infections Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago, Santiago de Compostela, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBER-ES), Madrid, Spain., Bello X; Unidade de Xenética, Instituto de Ciencias Forenses (INCIFOR), Facultade de Medicina, Universidade de Santiago de Compostela, and GenPoB Research Group, Instituto de Investigaciones Sanitarias, Hospital Clínico Universitario de Santiago (SERGAS), Santiago de Compostela, Galicia, Spain.; 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Genomics Research Department, Saudi Human Genome Project, King Fahad Medical City and King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia., Cai F; Genentech Inc, South San Francisco, California, United States of America., Soranzo N; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, United Kingdom., Butterworth A; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, United Kingdom., Geschwind DH; Department of Neurology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, United States of America., Arteaga S; Department of Neurology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, United States of America., Stephens A; Department of Pediatrics, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, United States of America., Butte MJ; Department of Pediatrics, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, United States of America.; Department of Microbiology, Immunology, and Molecular Genetics (MIMG), David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, United States of America., Boutros PC; Department of Human Genetics, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, United States of America., Yamaguchi TN; Department of Human Genetics, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, United States of America., Tao S; Department of Human Genetics, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, United States of America., Eng S; Department of Human Genetics, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, United States of America., Sanders T; Office of Health Informatics and Analytics, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, United States of America., Tung PJ; 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Department of Computational Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, United States of America.; Department of Pathology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, United States of America., Yaspan B; Genentech Inc, South San Francisco, California, United States of America., Smieszek S; Vanda Pharmaceuticals, Washington, District of Columbia, United States of America., Rivolta C; Institute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, Switzerland.; Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom.; Department of Ophthalmology, University Hospital Basel, Basel, Switzerland., Bibert S; Infectious Diseases Service, Department of Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland., Bochud PY; Infectious Diseases Service, Department of Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland., Dabrowski M; MNM Bioscience Inc., Cambridge, Massachusetts, United States of America., Zawadzki P; MNM Bioscience Inc., Cambridge, Massachusetts, United States of America.; Faculty of Physics, Adam Mickiewicz University, Poznan, Poland., Sypniewski M; MNM Bioscience Inc., Cambridge, Massachusetts, United States of America., Kaja E; MNM Bioscience Inc., Cambridge, Massachusetts, United States of America.; Department of Medical Chemistry and Laboratory Medicine, Poznań University of Medical Sciences, Poznań, Poland., Chariyavilaskul P; Clinical Pharmacokinetics and Pharmacogenomics Research Unit, Department of Pharmacology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Nilaratanakul V; Healthcare-associated Infection Research Group STAR (Special Task Force for Activating Research) and Division of Infectious Diseases, Department of Medicine,Chulalongkorn University, Bangkok, Thailand., Hirankarn N; Center of Excellence in Immunology and Immune-mediated Diseases, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Shotelersuk V; Center of Excellence for Medical Genomics, Medical Genomics Cluster, and Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Pongpanich M; Department of Mathematics and Computer Science, Faculty of Science, Chulalongkorn University, Bangkok, Thailand., Phokaew C; Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Chetruengchai W; Center of Excellence for Medical Genomics, Medical Genomics Cluster, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Tokunaga K; Genome Medical Science Project, Research Institute, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan., Sugiyama M; Genome Medical Science Project, Research Institute, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan., Kawai Y; Genome Medical Science Project, National Center for Global Health and Medicine (NCGM), Tokyo, Japan., Hasegawa T; M&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan., Naito T; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Namkoong H; Department of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan., Edahiro R; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan., Kimura A; Institute of Research, Tokyo Medical and Dental University, Tokyo, Japan., Ogawa S; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan.; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan.; Department of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institute, Stockholm, Sweden., Kanai T; Division of Gastroenterology and Hepatology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan., Fukunaga K; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan., Okada Y; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan.; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan.; Center for Infectious Disease Education and Research (CiDER), Osaka University, Suita, Japan., Imoto S; Division of Health Medical Intelligence, Human Genome Center, the Institute of Medical Science, the University of Tokyo, Tokyo, Japan., Miyano S; M&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan., Mangul S; Department of Clinical Pharmacy, School of Pharmacy, University of Southern California, Los Angeles, California, United States of America., Abedalthagafi MS; Genomics Research Department, Saudi Human Genome Project, King Fahad Medical City and King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia., Zeberg H; Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden., Grzymski JJ; Center for Genomic Medicine, Desert Research Institute, Reno, Nevada United States of America., Washington NL; Helix, San Mateo, California, United States of America., Ossowski S; Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Tuebingen, Germany.; NGS Competence Center Tuebingen, Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Tuebingen, Germany., Ludwig KU; Institute of Human Genetics, School of Medicine and University Hospital Bonn, University of Bonn, Bonn, Germany.; West German Genome Center, site Bonn, University of Bonn, Bonn, Germany., Schulte EC; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.; 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Publikováno v: PLoS genetics [PLoS Genet] 2022 Nov 03; Vol. 18 (11), pp. e1010367. Date of Electronic Publication: 2022 Nov 03 (Print Publication: 2022).

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.

Autor: Mullins N; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. niamh.mullins@mssm.edu.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. niamh.mullins@mssm.edu., Forstner AJ; Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.; Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.; Centre for Human Genetics, University of Marburg, Marburg, Germany., O'Connell KS; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; NORMENT, University of Oslo, Oslo, Norway., Coombes B; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA., Coleman JRI; Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.; NIHR Maudsley BRC, King's College London, London, UK., Qiao Z; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia., Als TD; iSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark.; Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, Denmark.; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark., Bigdeli TB; Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.; VA NY Harbor Healthcare System, Brooklyn, NY, USA., Børte S; Research and Communication Unit for Musculoskeletal Health, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway., Bryois J; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Charney AW; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Drange OK; Department of Mental Health, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Department of Østmarka, Division of Mental Health Care, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Gandal MJ; Department of Psychiatry and Biobehavioral Science, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Hagenaars SP; Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.; NIHR Maudsley BRC, King's College London, London, UK., Ikeda M; Department of Psychiatry, School of Medicine, Fujita Health University, Toyoake, Japan., Kamitaki N; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Kim M; Department of Psychiatry and Biobehavioral Science, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Krebs K; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Panagiotaropoulou G; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany., Schilder BM; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Sloofman LG; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Steinberg S; deCODE Genetics/Amgen, Reykjavik, Iceland., Trubetskoy V; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany., Winsvold BS; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway., Won HH; Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Samsung Medical Center, Sungkyunkwan University, Seoul, South Korea., Abramova L; Russian Academy of Medical Sciences, Mental Health Research Center, Moscow, Russian Federation., Adorjan K; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany., Agerbo E; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.; Centre for Integrated Register-Based Research, Aarhus University, Aarhus, Denmark., Al Eissa M; Division of Psychiatry, University College London, London, UK., Albani D; Department of Neuroscience, Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Alliey-Rodriguez N; Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.; Northwestern University, Chicago, IL, USA., Anjorin A; Psychiatry, Berkshire Healthcare NHS Foundation Trust, Bracknell, UK., Antilla V; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Antoniou A; 2nd Department of Psychiatry, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece., Awasthi S; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany., Baek JH; Department of Psychiatry, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, South Korea., Bækvad-Hansen M; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark., Bass N; Division of Psychiatry, University College London, London, UK., Bauer M; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Beins EC; Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany., Bergen SE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Birner A; Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria., Bøcker Pedersen C; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.; Centre for Integrated Register-Based Research, Aarhus University, Aarhus, Denmark., Bøen E; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway., Boks MP; Psychiatry, Brain Center UMC Utrecht, Utrecht, the Netherlands., Bosch R; Instituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.; Department of Psychiatry, Hospital Universitari Vall d´Hebron, Barcelona, Spain.; Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.; Psychiatric Genetics Unit, Group of Psychiatry Mental Health and Addictions, Vall d´Hebron Research Institut (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain., Brum M; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany., Brumpton BM; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway., Brunkhorst-Kanaan N; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany., Budde M; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany., Bybjerg-Grauholm J; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark., Byerley W; Psychiatry, University of California San Francisco, San Francisco, CA, USA., Cairns M; University of Newcastle, Newcastle, New South Wales, Australia., Casas M; Instituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.; Department of Psychiatry, Hospital Universitari Vall d´Hebron, Barcelona, Spain.; Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.; Psychiatric Genetics Unit, Group of Psychiatry Mental Health and Addictions, Vall d´Hebron Research Institut (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain., Cervantes P; Mood Disorders Program, Department of Psychiatry, McGill University Health Center, Montreal, Quebec, Canada., Clarke TK; Division of Psychiatry, University of Edinburgh, Edinburgh, UK., Cruceanu C; Mood Disorders Program, Department of Psychiatry, McGill University Health Center, Montreal, Quebec, Canada.; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany., Cuellar-Barboza A; Department of Psychiatry, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico.; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA., Cunningham J; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Curtis D; Centre for Psychiatry, Queen Mary University of London, London, UK.; UCL Genetics Institute, University College London, London, UK., Czerski PM; Department of Psychiatry, Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland., Dale AM; Center for Multimodal Imaging and Genetics, Departments of Neurosciences, Radiology, and Psychiatry, University of California, San Diego, CA, USA., Dalkner N; Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria., David FS; Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany., Degenhardt F; Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Duisburg, Germany., Djurovic S; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.; NORMENT, Department of Clinical Science, University of Bergen, Bergen, Norway., Dobbyn AL; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Douzenis A; 2nd Department of Psychiatry, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece., Elvsåshagen T; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Neurology, Oslo University Hospital, Oslo, Norway.; NORMENT, KG Jebsen Centre for Psychosis Research, Oslo University Hospital, Oslo, Norway., Escott-Price V; Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Ferrier IN; Academic Psychiatry, Newcastle University, Newcastle upon Tyne, UK., Fiorentino A; Division of Psychiatry, University College London, London, UK., Foroud TM; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA., Forty L; Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Frank J; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Frei O; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Freimer NB; Department of Psychiatry and Biobehavioral Science, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA., Frisén L; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden., Gade K; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany., Garnham J; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada., Gelernter J; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA.; Departments of Genetics and Neuroscience, Yale University School of Medicine, New Haven, CT, USA., Giørtz Pedersen M; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.; Centre for Integrated Register-Based Research, Aarhus University, Aarhus, Denmark., Gizer IR; Department of Psychological Sciences, University of Missouri, Columbia, MO, USA., Gordon SD; Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Gordon-Smith K; Psychological Medicine, University of Worcester, Worcester, UK., Greenwood TA; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Grove J; iSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark.; Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, Denmark.; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark., Guzman-Parra J; Mental Health Department, University Regional Hospital, Biomedicine Institute (IBIMA), Málaga, Spain., Ha K; Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea., Haraldsson M; Landspitali University Hospital, Reykjavik, Iceland., Hautzinger M; Department of Psychology, Eberhard Karls Universität Tübingen, Tübingen, Germany., Heilbronner U; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany., Hellgren D; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Herms S; Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.; Department of Biomedicine, University of Basel, Basel, Switzerland.; Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland., Hoffmann P; Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.; Department of Biomedicine, University of Basel, Basel, Switzerland.; Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland., Holmans PA; Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Huckins L; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Jamain S; Neuropsychiatrie Translationnelle, Inserm U955, Créteil, France.; Faculté de Santé, Université Paris Est, Créteil, France., Johnson JS; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kalman JL; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.; International Max Planck Research School for Translational Psychiatry (IMPRS-TP), Munich, Germany., Kamatani Y; Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Kennedy JL; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.; Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada., Kittel-Schneider S; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany.; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany., Knowles JA; Cell Biology, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA.; Institute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA., Kogevinas M; ISGlobal, Barcelona, Spain., Koromina M; Laboratory of Pharmacogenomics and Individualized Therapy, Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece., Kranz TM; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany., Kranzler HR; Mental Illness Research, Education and Clinical Center, Crescenz VAMC, Philadelphia, PA, USA.; Center for Studies of Addiction, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Kubo M; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Kupka R; Psychiatry, Altrecht, Utrecht, the Netherlands.; Psychiatry, GGZ inGeest, Amsterdam, the Netherlands.; Psychiatry, VU Medisch Centrum, Amsterdam, the Netherlands., Kushner SA; Department of Psychiatry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Lavebratt C; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Lawrence J; Psychiatry, North East London NHS Foundation Trust, Ilford, UK., Leber M; Clinic for Psychiatry and Psychotherapy, University Hospital Cologne, Cologne, Germany., Lee HJ; Department of Psychiatry, Korea University College of Medicine, Seoul, South Korea., Lee PH; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Levy SE; HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA., Lewis C; Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Liao C; Department of Human Genetics, McGill University, Montréal, Quebec, Canada.; Montreal Neurological Institute and Hospital, McGill University, Montréal, Quebec, Canada., Lucae S; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany., Lundberg M; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., MacIntyre DJ; Division of Psychiatry, Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK., Magnusson SH; deCODE Genetics/Amgen, Reykjavik, Iceland., Maier W; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany., Maihofer A; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Malaspina D; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Maratou E; Clinical Biochemistry Laboratory, Attikon General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Martinsson L; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden., Mattheisen M; iSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark.; Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, Denmark.; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany.; Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden., McCarroll SA; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., McGregor NW; Systems Genetics Working Group, Department of Genetics, Stellenbosch University, Stellenbosch, South Africa., McGuffin P; Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK., McKay JD; Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France., Medeiros H; Institute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA., Medland SE; Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Millischer V; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Montgomery GW; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia., Moran JL; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA., Morris DW; Centre for Neuroimaging and Cognitive Genomics (NICOG), National University of Ireland Galway, Galway, Ireland., Mühleisen TW; Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.; Department of Biomedicine, University of Basel, Basel, Switzerland., O'Brien N; Division of Psychiatry, University College London, London, UK., O'Donovan C; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada., Olde Loohuis LM; Department of Psychiatry and Biobehavioral Science, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA., Oruc L; Medical Faculty, School of Science and Technology, University Sarajevo, Sarajevo, Bosnia and Herzegovina., Papiol S; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany., Pardiñas AF; Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Perry A; Psychological Medicine, University of Worcester, Worcester, UK., Pfennig A; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Porichi E; 2nd Department of Psychiatry, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece., Potash JB; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Quested D; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK.; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK., Raj T; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Rapaport MH; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA., DePaulo JR; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Regeer EJ; Outpatient Clinic for Bipolar Disorder, Altrecht, Utrecht, the Netherlands., Rice JP; Department of Psychiatry, Washington University in Saint Louis, Saint Louis, MO, USA., Rivas F; Mental Health Department, University Regional Hospital, Biomedicine Institute (IBIMA), Málaga, Spain., Rivera M; Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, Granada, Spain.; Institute of Neurosciences, Biomedical Research Center (CIBM), University of Granada, Granada, Spain., Roth J; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany., Roussos P; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ruderfer DM; Medicine, Psychiatry, Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Sánchez-Mora C; Instituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.; Department of Psychiatry, Hospital Universitari Vall d´Hebron, Barcelona, Spain.; Psychiatric Genetics Unit, Group of Psychiatry Mental Health and Addictions, Vall d´Hebron Research Institut (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.; Department of Genetics, Microbiology and Statistics, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain., Schulte EC; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany., Senner F; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany., Sharp S; Division of Psychiatry, University College London, London, UK., Shilling PD; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Sigurdsson E; Landspitali University Hospital, Reykjavik, Iceland.; Faculty of Medicine, Department of Psychiatry, School of Health Sciences, University of Iceland, Reykjavik, Iceland., Sirignano L; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Slaney C; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada., Smeland OB; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; NORMENT, University of Oslo, Oslo, Norway., Smith DJ; Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK., Sobell JL; Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, CA, USA., Søholm Hansen C; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark., Soler Artigas M; Instituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.; Department of Psychiatry, Hospital Universitari Vall d´Hebron, Barcelona, Spain.; Psychiatric Genetics Unit, Group of Psychiatry Mental Health and Addictions, Vall d´Hebron Research Institut (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.; Department of Genetics, Microbiology and Statistics, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain., Spijker AT; Mood Disorders, PsyQ, Rotterdam, the Netherlands., Stein DJ; SAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Strauss JS; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada., Świątkowska B; Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland., Terao C; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Thorgeirsson TE; deCODE Genetics/Amgen, Reykjavik, Iceland., Toma C; Neuroscience Research Australia, Sydney, New South Wales, Australia.; School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia.; Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid and CSIC, Madrid, Spain., Tooney P; University of Newcastle, Newcastle, New South Wales, Australia., Tsermpini EE; Laboratory of Pharmacogenomics and Individualized Therapy, Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece., Vawter MP; Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, Irvine, CA, USA., Vedder H; Psychiatry, Psychiatrisches Zentrum Nordbaden, Wiesloch, Germany., Walters JTR; Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Witt SH; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Xi S; Computational Sciences Center of Emphasis, Pfizer Global Research and Development, Cambridge, MA, USA., Xu W; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada., Yang JMK; Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Young AH; Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; South London and Maudsley NHS Foundation Trust, Bethlem Royal Hospital, Beckenham, UK., Young H; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Zandi PP; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Zhou H; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA., Zillich L; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Adolfsson R; Department of Clinical Sciences, Psychiatry, Umeå University Medical Faculty, Umeå, Sweden., Agartz I; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.; Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden.; NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Institute of Clinical Medicine and Diakonhjemmet Hospital, University of Oslo, Oslo, Norway., Alda M; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.; National Institute of Mental Health, Klecany, Czech Republic., Alfredsson L; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Babadjanova G; Institute of Pulmonology, Russian State Medical University, Moscow, Russian Federation., Backlund L; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Baune BT; Department of Psychiatry, University of Münster, Münster, Germany.; Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia.; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia., Bellivier F; Université de Paris, INSERM, Optimisation Thérapeutique en Neuropsychopharmacologie, UMRS 1144, Paris, France.; APHP Nord, DMU Neurosciences, Département de Psychiatrie et de Médecine Addictologique, GHU Saint Louis-Lariboisière-Fernand Widal, Paris, France., Bengesser S; Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria., Berrettini WH; Psychiatry, University of Pennsylvania, Philadelphia, PA, USA., Blackwood DHR; Division of Psychiatry, University of Edinburgh, Edinburgh, UK., Boehnke M; Center for Statistical Genetics and Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA., Børglum AD; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Department of Biomedicine and the iSEQ Center, Aarhus University, Aarhus, Denmark.; Center for Genomics and Personalized Medicine, CGPM, Aarhus, Denmark., Breen G; Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.; NIHR Maudsley BRC, King's College London, London, UK., Carr VJ; School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia., Catts S; University of Queensland, Brisbane, Queensland, Australia., Corvin A; Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland., Craddock N; Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Dannlowski U; Department of Psychiatry, University of Münster, Münster, Germany., Dikeos D; 1st Department of Psychiatry, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece., Esko T; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.; Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Division of Endocrinology, Children's Hospital Boston, Boston, MA, USA., Etain B; Université de Paris, INSERM, Optimisation Thérapeutique en Neuropsychopharmacologie, UMRS 1144, Paris, France.; APHP Nord, DMU Neurosciences, Département de Psychiatrie et de Médecine Addictologique, GHU Saint Louis-Lariboisière-Fernand Widal, Paris, France., Ferentinos P; Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.; 2nd Department of Psychiatry, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece., Frye M; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA., Fullerton JM; Neuroscience Research Australia, Sydney, New South Wales, Australia.; School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia., Gawlik M; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany., Gershon ES; Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.; Department of Human Genetics, University of Chicago, Chicago, IL, USA., Goes FS; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Green MJ; Neuroscience Research Australia, Sydney, New South Wales, Australia.; School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia., Grigoroiu-Serbanescu M; Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania., Hauser J; Department of Psychiatry, Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland., Henskens F; University of Newcastle, Newcastle, New South Wales, Australia., Hillert J; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden., Hong KS; Department of Psychiatry, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, South Korea., Hougaard DM; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark., Hultman CM; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Hveem K; K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway., Iwata N; Department of Psychiatry, School of Medicine, Fujita Health University, Toyoake, Japan., Jablensky AV; University of Western Australia, Nedlands, Western Australia, Australia., Jones I; Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Jones LA; Psychological Medicine, University of Worcester, Worcester, UK., Kahn RS; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Psychiatry, Brain Center UMC Utrecht, Utrecht, the Netherlands., Kelsoe JR; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Kirov G; Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Landén M; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden., Leboyer M; Neuropsychiatrie Translationnelle, Inserm U955, Créteil, France.; Faculté de Santé, Université Paris Est, Créteil, France.; Department of Psychiatry and Addiction Medicine, Assistance Publique - Hôpitaux de Paris, Paris, France., Lewis CM; Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.; NIHR Maudsley BRC, King's College London, London, UK.; Department of Medical and Molecular Genetics, King's College London, London, UK., Li QS; Neuroscience Therapeutic Area, Janssen Research and Development, LLC, Titusville, NJ, USA., Lissowska J; Cancer Epidemiology and Prevention, M. Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Lochner C; SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa., Loughland C; University of Newcastle, Newcastle, New South Wales, Australia., Martin NG; Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Psychology, The University of Queensland, Brisbane, Queensland, Australia., Mathews CA; Department of Psychiatry and Genetics Institute, University of Florida, Gainesville, FL, USA., Mayoral F; Mental Health Department, University Regional Hospital, Biomedicine Institute (IBIMA), Málaga, Spain., McElroy SL; Research Institute, Lindner Center of HOPE, Mason, OH, USA., McIntosh AM; Division of Psychiatry, Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK., McMahon FJ; Human Genetics Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA., Melle I; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Division of Mental Health and Addiction, University of Oslo, Institute of Clinical Medicine, Oslo, Norway., Michie P; University of Newcastle, Newcastle, New South Wales, Australia., Milani L; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Mitchell PB; School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia., Morken G; Department of Mental Health, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Psychiatry, St Olavs University Hospital, Trondheim, Norway., Mors O; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Psychosis Research Unit, Aarhus University Hospital - Psychiatry, Risskov, Denmark., Mortensen PB; iSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark.; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.; Centre for Integrated Register-Based Research, Aarhus University, Aarhus, Denmark., Mowry B; University of Queensland, Brisbane, Queensland, Australia., Müller-Myhsok B; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; University of Liverpool, Liverpool, UK., Myers RM; HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA., Neale BM; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Nievergelt CM; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; Research/Psychiatry, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA., Nordentoft M; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen, Denmark., Nöthen MM; Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany., O'Donovan MC; Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Oedegaard KJ; Division of Psychiatry, Haukeland Universitetssjukehus, Bergen, Norway.; Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway., Olsson T; Department of Clinical Neuroscience and Center for Molecular Medicine, Karolinska Institutet at Karolinska University Hospital, Solna, Sweden., Owen MJ; Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Paciga SA; Human Genetics and Computational Biomedicine, Pfizer Global Research and Development, Groton, CT, USA., Pantelis C; University of Melbourne, Melbourne, Victoria, Australia., Pato C; Institute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA., Pato MT; Institute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA., Patrinos GP; Laboratory of Pharmacogenomics and Individualized Therapy, Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece.; Department of Pathology, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates.; Zayed Center of Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates., Perlis RH; Psychiatry, Harvard Medical School, Boston, MA, USA.; Division of Clinical Research, Massachusetts General Hospital, Boston, MA, USA., Posthuma D; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Department of Clinical Genetics, Amsterdam Neuroscience, Vrije Universiteit Medical Center, Amsterdam, the Netherlands., Ramos-Quiroga JA; Instituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.; Department of Psychiatry, Hospital Universitari Vall d´Hebron, Barcelona, Spain.; Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.; Psychiatric Genetics Unit, Group of Psychiatry Mental Health and Addictions, Vall d´Hebron Research Institut (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain., Reif A; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany., Reininghaus EZ; Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria., Ribasés M; Instituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.; Department of Psychiatry, Hospital Universitari Vall d´Hebron, Barcelona, Spain.; Psychiatric Genetics Unit, Group of Psychiatry Mental Health and Addictions, Vall d´Hebron Research Institut (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.; Department of Genetics, Microbiology and Statistics, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain., Rietschel M; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Ripke S; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Rouleau GA; Montreal Neurological Institute and Hospital, McGill University, Montréal, Quebec, Canada.; Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Quebec, Canada., Saito T; Department of Psychiatry, School of Medicine, Fujita Health University, Toyoake, Japan., Schall U; University of Newcastle, Newcastle, New South Wales, Australia., Schalling M; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Schofield PR; Neuroscience Research Australia, Sydney, New South Wales, Australia.; School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia., Schulze TG; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA., Scott LJ; Center for Statistical Genetics and Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA., Scott RJ; University of Newcastle, Newcastle, New South Wales, Australia., Serretti A; Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy., Shannon Weickert C; Neuroscience Research Australia, Sydney, New South Wales, Australia.; School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.; Department of Neuroscience, SUNY Upstate Medical University, Syracuse, NY, USA., Smoller JW; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.; Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Massachusetts General Hospital, Boston, MA, USA., Stefansson H; deCODE Genetics/Amgen, Reykjavik, Iceland., Stefansson K; deCODE Genetics/Amgen, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Stordal E; 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Publikováno v: Nature genetics [Nat Genet] 2021 Jun; Vol. 53 (6), pp. 817-829. Date of Electronic Publication: 2021 May 17.

Landscape of Conditional eQTL in Dorsolateral Prefrontal Cortex and Co-localization with Schizophrenia GWAS.

Autor: Dobbyn A; Division of Psychiatric Genomics, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Huckins LM; Division of Psychiatric Genomics, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Boocock J; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90024, USA., Sloofman LG; Division of Psychiatric Genomics, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Glicksberg BS; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Institute for Next Generation Healthcare, Mount Sinai Health System, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Giambartolomei C; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA., Hoffman GE; Division of Psychiatric Genomics, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Perumal TM; Systems Biology, Sage Bionetworks, Seattle, WA 98109, USA., Girdhar K; Division of Psychiatric Genomics, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Jiang Y; Division of Psychiatric Genomics, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Raj T; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Ruderfer DM; Division of Genetic Medicine, Department of Medicine, Psychiatry and Biomedical Informatics, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN 37235, USA., Kramer RS; Human Brain Collection Core, National Institute of Mental Health, Bethesda, MD 20892, USA., Pinto D; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Psychiatry and Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Akbarian S; Division of Psychiatric Genomics, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Roussos P; Division of Psychiatric Genomics, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Domenici E; Laboratory of Neurogenomic Biomarkers, Centre for Integrative Biology (CIBIO), University of Trento, Trento, Italy; The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto (TN), Italy., Devlin B; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Sklar P; Division of Psychiatric Genomics, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Stahl EA; Division of Psychiatric Genomics, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: eli.stahl@mssm.edu., Sieberts SK; Systems Biology, Sage Bionetworks, Seattle, WA 98109, USA. Electronic address: solly.sieberts@sagebase.org.

Publikováno v: American journal of human genetics [Am J Hum Genet] 2018 Jun 07; Vol. 102 (6), pp. 1169-1184. Date of Electronic Publication: 2018 May 24.