Unveiling the potential anticancer activity of new dihydropyrimidines through dual inhibition of EGFR and TrkA: Design, synthesis, and in silico study

Autor: Slly, Aya M., Ewes, Wafaa A., Bayoumi, Waleed A., Selim, Khalid B.

Publikováno v: In Bioorganic Chemistry January 2025 154

Unveiling the potential anticancer activity of new dihydropyrimidines through dual inhibition of EGFR and TrkA: Design, synthesis, and in silico study.

Autor: Slly AM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt., Ewes WA; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt., Bayoumi WA; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt. Electronic address: waleedbayoumi@mans.edu.eg., Selim KB; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2024 Nov 20; Vol. 154, pp. 107962. Date of Electronic Publication: 2024 Nov 20.