Deficiency of the metabolic enzyme SCHAD in pancreatic β-cells promotes amino acid-sensitive hypoglycemia.

Autor: St-Louis JL; Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, USA; Department of Clinical Medicine, Gade Laboratory for Pathology, University of Bergen, Bergen, Norway., El Jellas K; Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, USA; Department of Clinical Medicine, Gade Laboratory for Pathology, University of Bergen, Bergen, Norway., Velasco K; Department of Clinical Medicine, Gade Laboratory for Pathology, University of Bergen, Bergen, Norway., Slipp BA; Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, USA., Hu J; Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, USA., Helgeland G; Department of Clinical Medicine, Gade Laboratory for Pathology, University of Bergen, Bergen, Norway., Steine SJ; Department of Clinical Medicine, Gade Laboratory for Pathology, University of Bergen, Bergen, Norway., De Jesus DF; Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, USA; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA; Harvard Stem Cell Institute, Boston, USA., Kulkarni RN; Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, USA; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA; Harvard Stem Cell Institute, Boston, USA., Molven A; Department of Clinical Medicine, Gade Laboratory for Pathology, University of Bergen, Bergen, Norway; Department of Pathology, Haukeland University Hospital, Bergen, Norway; Section for Cancer Genomics, Haukeland University Hospital, Bergen, Norway. Electronic address: anders.molven@uib.no.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2023 Aug; Vol. 299 (8), pp. 104986. Date of Electronic Publication: 2023 Jun 29.