Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Slavoljub Vujcic"'
Autor:
David Frescas, Evguenia Strom, Tamara Tchkonia, Valeria Kogan, Brandon M. Hall, Slavoljub Vujcic, Yi Zhu, Peter Krasnov, James L. Kirkland, Olga B. Chernova, Igor Koman, Marina P. Antoch, Andrei V. Gudkov, Olga V. Leontieva, Anatoli S. Gleiberman
Publikováno v:
Aging Cell
Adipose tissue is recognized as a major source of systemic inflammation with age, driving age‐related tissue dysfunction and pathogenesis. Macrophages (Mφ) are central to these changes yet adipose tissue Mφ (ATMs) from aged mice remain poorly cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23db66c340cf3e954a94d54922273730
http://europepmc.org/articles/PMC7576241
http://europepmc.org/articles/PMC7576241
Autor:
Elena Rydkina, Peter Krasnov, Karina Balan, Vitaly Balan, Evguenia Strom, Brandon M. Hall, Anatoli S. Gleiberman, Camila Rosat Consiglio, Sandra O. Gollnick, Andrei V. Gudkov, Ilya Gitlin, Slavoljub Vujcic, Lauren P. Virtuoso, Katerina I. Leonova, Olga B. Chernova
Publikováno v:
Aging (Albany NY)
Constitutive p16Ink4a expression, along with senescence-associated β-galactosidase (SAβG), are commonly accepted biomarkers of senescent cells (SCs). Recent reports attributed improvement of the healthspan of aged mice following p16Ink4a-positive c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf409a562dc24a7dbe07fa1490b9eab
http://europepmc.org/articles/PMC5611982
http://europepmc.org/articles/PMC5611982
Autor:
David Frescas, Brandon M. Hall, Slavoljub Vujcic, Lauren P. Virtuoso, Mahima Gupta, Evguenia Strom, Olga B. Chernova, Elena Rydkina, Anatoli S. Gleiberman, Vitaly Balan, Andrei V. Gudkov
Publikováno v:
Cell Cycle. 16:1526-1533
Age-related health decline has been attributed to the accumulation of senescent cells recognized in vivo by p16(Ink4a) expression. The pharmacological elimination of p16(Ink4a)-positive cells from the tissues of mice was shown to extend a healthy lif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00069bbfd5317561dc69bf20edd2809a
https://doi.org/10.1080/15384101.2017.1339850
https://doi.org/10.1080/15384101.2017.1339850
Autor:
Peter Krasnov, Ilia Toshkov, Michelle Haber, Michelle J. Henderson, Mahima Gupta, Pavel G. Komarov, Slavoljub Vujcic, Richard B. Lock, Yuan Tian, Murray D. Norris, Shiloh Middlemiss, Sangeeta Joshi, Denis N. Kazyulkin, Jean Veith, Lioubov G. Korotchkina, Eugene Kononov, Mikhail V. Chernov, Olga B. Chernova, Marina P. Antoch, Klaartje Somers, Andrei V. Gudkov, Alex Polinsky, Ekaterina L. Andrianova
Publikováno v:
Leukemia
Effective treatment of some types of cancer can be achieved by modulating cell lineage-specific rather than tumor-specific targets. We conducted a systematic search for novel agents selectively toxic to cells of hematopoietic origin. Chemical library
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968c0d33d195d064d123c2e55b563e6b
https://pubmed.ncbi.nlm.nih.gov/31896781
https://pubmed.ncbi.nlm.nih.gov/31896781
Autor:
Vitaly Balan, Peter Krasnov, Brandon M. Hall, Katerina I. Leonova, Evguenia Strom, Karina Balan, Olga B. Chernova, Ilya Gitlin, Slavoljub Vujcic, Andrei V. Gudkov, Lauren P. Virtuoso, Anatoli S. Gleiberman, Elena Rydkina, Alexander Polinsky
Publikováno v:
Aging (Albany NY)
Senescent cells (SCs) have been considered a source of age-related chronic sterile systemic inflammation and a target for anti-aging therapies. To understand mechanisms controlling the amount of SCs, we analyzed the phenomenon of rapid clearance of h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c452b3e3cc4b4e2193bba213773cc838
https://pubmed.ncbi.nlm.nih.gov/28783709
https://pubmed.ncbi.nlm.nih.gov/28783709
Autor:
Slavoljub Vujcic, Riitta Sinervirta, Alex R. Khomutov, Jouko Vepsäläinen, Juhani Jänne, Leena Alhonen, Carl W. Porter, Aki Järvinen, Anne Uimari, Nikolay Grigorenko, Mervi T. Hyvönen, Tuomo A. Keinänen
Publikováno v:
Journal of Biological Chemistry. 280:6595-6601
Metabolically stable polyamine derivatives may serve as useful surrogates for the natural polyamines in studies aimed to elucidate the functions of individual polyamines. Here we studied the metabolic stability of alpha-methylspermidine, alpha-methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62819b3c1d11a2af5117b2690cbf544c
https://doi.org/10.1074/jbc.m412788200
https://doi.org/10.1074/jbc.m412788200
Autor:
Salim Merali, Barbara A. Foster, Slavoljub Vujcic, Debora L. Kramer, Mary L. Hensen, Carl W. Porter, Kristin Kee, Richard Mazurchuk, Paula Diegelman, Nicholas Kisiel
Publikováno v:
Journal of Biological Chemistry. 279:40076-40083
The enzyme spermidine/spermine N(1)-acetyltransferase (SSAT) regulates the catabolism and export of intracellular polyamines. We have previously shown that activation of polyamine catabolism by conditional overexpression of SSAT has antiproliferative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ea5b4f783f1b0de97905a98566b18c9
https://doi.org/10.1074/jbc.m406002200
https://doi.org/10.1074/jbc.m406002200
Publikováno v:
Molecular Pharmacology. 64:1153-1159
N1,N11-diethylnorspermine (DENSPM) is a polyamine analog that down-regulates polyamine biosynthesis and potently upregulates the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase (SSAT). In certain cells, such as SKMEL-28 human mela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c940d795d697fad0b20535038173bb34
https://doi.org/10.1124/mol.64.5.1153
https://doi.org/10.1124/mol.64.5.1153
Autor:
Mikhail V. Chernov, Andrei V. Gudkov, Alexander Polinsky, Slavoljub Vujcic, Denis N. Kazyulkin, Sangeeta Joshi, Lioubov G. Korotchkina, Olga B. Chernova, Ilya Toshkov, Katerina Andrianova
Publikováno v:
Cancer Research. 77:1178-1178
Effective anticancer drugs can be directed against cell lineage-specific, rather than tumor-specific, targets (i.e., androgen receptor, CD20, etc.). We sought to conduct systematic search for novel agents that are selectively cytotoxic to hematopoiet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::585e9838ed0d389738196c24ed4a9ad3
https://doi.org/10.1158/1538-7445.am2017-1178
https://doi.org/10.1158/1538-7445.am2017-1178
Autor:
Slavoljub Vujcic, Debora L. Kramer, Anne Karppinen, Maria Halmekytö, Ryan Hines, Mikko Uusi-Oukari, Carl W. Porter, Leena Alhonen, Veli-Pekka Korhonen, Juhani Jänne
Publikováno v:
Journal of Biological Chemistry. 273:1964-1969
A recently generated transgenic mouse line having activated polyamine catabolism due to systemic overexpression of spermidine/spermine N1-acetyltransferase (SSAT) was used to isolate primary fetal fibroblasts as a means to further elucidate the cellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c323b01ad9866c2b7237438ed6f2882b
https://doi.org/10.1074/jbc.273.4.1964
https://doi.org/10.1074/jbc.273.4.1964