Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Slavica Brnjic"'
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7238 (2009)
BACKGROUND:Natural product structures have high chemical diversity and are attractive as lead structures for discovery of new drugs. One of the disease areas where natural products are most frequently used as therapeutics is oncology. METHOD AND FIND
Externí odkaz:
https://doaj.org/article/4d987919ebf341eaa36ef15141ffff3c
Autor:
Stig Linder, Karthik Selvaraju, Xiaonan Zhang, Padraig D'Arcy, Slavica Brnjic, Magdalena Mazurkiewicz, Ellin-Kristina Hillert, Arjan Mofers, Amir Ata Saei, Roman A. Zubarev
Publikováno v:
Cancer Letters. 448:70-83
Proteasome inhibitors have been shown to induce cell death in cancer cells by triggering an acute proteotoxic stress response characterized by accumulation of poly-ubiquitinated proteins, ER stress and the production of reactive oxygen species. The a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d57bf3bc3df9f0594b3b6045fd3a54
https://doi.org/10.1016/j.canlet.2019.02.003
https://doi.org/10.1016/j.canlet.2019.02.003
Autor:
Rolf Larsson, Stig Linder, Chao Sun, Xiaonan Zhang, Padraig D'Arcy, Slavica Brnjic, Mårten Fryknäs, Magdalena Mazurkiewicz
Publikováno v:
Antioxidants & Redox Signaling. 21:2271-2285
Aims: b-AP15 is a recently described inhibitor of the USP14/UCHL5 deubiquitinases (DUBs) of the 19S proteasome. Exposure to b-AP15 results in blocking of proteasome function and accumulation of polyubiquitinated protein substrates in cells. This nove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79fde979c2315c9ddfaccced0e988341
https://doi.org/10.1089/ars.2013.5322
https://doi.org/10.1089/ars.2013.5322
Autor:
Paola Pellegrini, Stig Linder, Slavica Brnjic, Katja Pokrovskaja Tamm, Hanif Rassoolzadeh, Dan Grandér, Sofi Forsberg, Rolf Larsson, Elin Edsbäcker, Elise G. Holvey-Bates, Angelo De Milito, George Stark Stark, Iryna Kolosenko, HyeonJoo Cheon, Per Johnsson, Mårten Fryknäs
Publikováno v:
International Journal of Cancer. 136:E51-E61
The mechanism of multicellular drug resistance, defined as the reduced efficacy of chemotherapeutic drugs in solid tumors is incompletely understood. Here we report that colon carcinoma cells cultured as 3D microtissues (spheroids) display dramatic i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d2de4e1838000dae4b56143c703d011
https://doi.org/10.1002/ijc.29161
https://doi.org/10.1002/ijc.29161
Autor:
Behnam Sadeghi, Maria Hägg Olofsson, Rolf Larsson, Padraig D'Arcy, Mårten Fryknäs, Paola Perego, Slavica Brnjic, Moustapha Hassan, Michelandrea De Cesare, Stig Linder, Kristina Lindsten
Publikováno v:
Nature Medicine. 17:1636-1640
Ubiquitin-tagged substrates are degraded by the 26S proteasome, which is a multisubunit complex comprising a proteolytic 20S core particle capped by 19S regulatory particles. The approval of bortezomib for the treatment of multiple myeloma validated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af1c16055d44dc0d81b34535390afa4d
https://doi.org/10.1038/nm.2536
https://doi.org/10.1038/nm.2536
Publikováno v:
OncoTargets and Therapy, Vol 2008, Iss default, Pp 67-78 (2008)
Wessen Maruwge1, Pádraig D’Arcy1, Annika Folin1,2, Slavica Brnjic1, Johan Wejde1, Anthony Davis1, Fredrik Erlandsson3, Jonas Bergh1,2, Bertha Brodin11Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden; 2Radiumhemmet, Ka
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doajarticles::6560ff20bb2867c5e8057ce2935e389d
http://www.dovepress.com/sorafenib-inhibits-tumor-growth-and-vascularization-of-rhabdomyosarcom-a2640
http://www.dovepress.com/sorafenib-inhibits-tumor-growth-and-vascularization-of-rhabdomyosarcom-a2640
Autor:
Jonas Bergh, Johan Wejde, Padraig D'Arcy, Wessen Maruwge, Bertha Brodin, Fredrik Erlandsson, Slavica Brnjic, Anthony Davis, Annika Folin
Publikováno v:
OncoTargets and therapy
Wessen Maruwge1, Pádraig D’Arcy1, Annika Folin1,2, Slavica Brnjic1, Johan Wejde1, Anthony Davis1, Fredrik Erlandsson3, Jonas Bergh1,2, Bertha Brodin11Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden; 2Radiumhemmet, Ka
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e595a78f6025092e2fe59cceb3956e5b
http://europepmc.org/articles/PMC2994208
http://europepmc.org/articles/PMC2994208
Autor:
Iryna, Kolosenko, Mårten, Fryknäs, Sofi, Forsberg, Per, Johnsson, HyeonJoo, Cheon, Elise G, Holvey-Bates, Elin, Edsbäcker, Paola, Pellegrini, Hanif, Rassoolzadeh, Slavica, Brnjic, Rolf, Larsson, George R, Stark, Dan, Grandér, Stig, Linder, Katja Pokrovskaja, Tamm, Angelo, De Milito
Publikováno v:
International journal of cancer. 136(4)
The mechanism of multicellular drug resistance, defined as the reduced efficacy of chemotherapeutic drugs in solid tumors is incompletely understood. Here we report that colon carcinoma cells cultured as 3D microtissues (spheroids) display dramatic i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::48618d57e43ebdac286c39ebd74e24ec
https://pubmed.ncbi.nlm.nih.gov/25156627
https://pubmed.ncbi.nlm.nih.gov/25156627
Autor:
Paola Pellegrini, Xiaonan Zhang, Giuseppe Di Lernia, Maria Hägg, Patrice Codogno, Angelo De Milito, Stig Linder, Mojgan Djavaheri-Mergny, Maria Marino, Stefano Fais, Slavica Brnjic
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2012, 287 (36), pp.30664-30676. ⟨10.1074/jbc.M112.339127⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2012, 287 (36), pp.30664-30676. ⟨10.1074/jbc.M112.339127⟩
International audience; Cyclic hypoxia and alterations in oncogenic signaling contribute to switch cancer cell metabolism from oxidative phosphorylation to aerobic glycolysis. A major consequence of up-regulated glycolysis is the increased production
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ba3a1e0fe1d491454b989e03db411a
https://pubmed.ncbi.nlm.nih.gov/22761435
https://pubmed.ncbi.nlm.nih.gov/22761435
Autor:
Slavica Brnjic, Angelo De Milito, Karolina Lesiak-Mieczkowska, Mårten Fryknäs, Rolf Larsson, Vivien Schmidt, Emma Hernlund, Padraig D'Arcy, Walid Fayad, Maria Hägg Olofsson, Tobias Sjöblom, Xiaonan Zhang, Stig Linder
Publikováno v:
European journal of cancer (Oxford, England : 1990). 48(3)
PURPOSE:Regrowth of tumour cells between cycles of chemotherapy is a significant clinical problem. Treatment strategies where antiproliferative agents are used to inhibit tumour regrowth between chemotherapy cycles are attractive, but such strategies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097ca30da059f1941ae2becc60536cde
https://pubmed.ncbi.nlm.nih.gov/22154651
https://pubmed.ncbi.nlm.nih.gov/22154651