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Regulation of sarcomere formation and function in the healthy heart requires a titin intronic enhancer.

Autor: Kim Y; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, United States of America., Kim SW; Department of Genetics, Harvard Medical School, Boston, United States of America., Saul D; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, United States of America., Neyazi M; Department of Genetics, Harvard Medical School, Boston, United States of America., Schmid M; Department of Genetics, Harvard Medical School, Boston, United States of America., Wakimoto H; Department of Genetics, Harvard Medical School, Boston, United States of America., Slaven N; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, United States of America., Lee JH; Department of Biomedical Engineering, Boston University, Boston, United States of America., Layton OG; Department of Genetics, Harvard Medical School, Boston, United States of America., Wasson LK; Department of Genetics, Harvard Medical School, Boston, United States of America., Letendre JH; Department of Biomedical Engineering, Boston University, Boston, United States of America., Xiao F; Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America., Ewoldt JK; Department of Biomedical Engineering, Boston University, Boston, United States of America., Gkatzis K; Ksilink, Strasbourg, France., Sommer P; Ksilink, Strasbourg, France., Gobert B; Ksilink, Strasbourg, France., Wiest-Daesslé N; Ksilink, Strasbourg, France., McAfee Q; Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America., Singhal N; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, United States of America., Lun M; Department of Genetics, Harvard Medical School, Boston, United States of America., Gorham JM; Department of Genetics, Harvard Medical School, Boston, United States of America., Arany Z; Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America., Sharma A; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America., Toepfer CN; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom., Oudit GY; Department of Medicine, University of Alberta, Edmonton, Canada., Pu WT; Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, United States of America., Dickel DE; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, United States of America., Pennacchio LA; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, United States of America., Visel A; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, United States of America., Chen CS; Department of Biomedical Engineering, Boston University, Boston, United States of America., Seidman JG; Department of Genetics, Harvard Medical School, Boston, United States of America., Seidman CE; Department of Genetics, Harvard Medical School, Boston, United States of America.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2024 Dec 17. Date of Electronic Publication: 2024 Dec 17.