Zobrazeno 1 - 10
of 200
pro vyhledávání: '"Slava, Ziegler"'
Autor:
Lin Wang, Furkan Yilmaz, Okan Yildirim, Beate Schölermann, Sukdev Bag, Luca Greiner, Axel Pahl, Sonja Sievers, Rebecca Scheel, Carsten Strohmann, Christopher Squire, Daniel J. Foley, Slava Ziegler, Michael Grigalunas, Herbert Waldmann
Publikováno v:
Advanced Science, Vol 11, Iss 21, Pp n/a-n/a (2024)
Abstract The pseudo‐natural product (pseudo‐NP) concept aims to combine NP fragments in arrangements that are not accessible through known biosynthetic pathways. The resulting compounds retain the biological relevance of NPs but are not yet linke
Externí odkaz:
https://doaj.org/article/9073737db646428dab117fefc2793b21
Autor:
Jana Flegel, Saad Shaaban, Zhi Jun Jia, Britta Schulte, Yilong Lian, Adrian Krzyzanowski, Malte Metz, Tabea Schneidewind, Fabian Wesseler, Anke Flegel, Alisa Reich, Alexandra Brause, Gang Xue, Minghao Zhang, Lara Dötsch, Isabelle D. Stender, Jan-Erik Hoffmann, Rebecca Scheel, Petra Janning, Fraydoon Rastinejad, Dennis Schade, Carsten Strohmann, Andrey P. Antonchick, Sonja Sievers, Pedro Moura-Alves, Slava Ziegler, Herbert Waldmann
Publikováno v:
Journal of Medicinal Chemistry. 65:16268-16289
Identification and analysis of small molecule bioactivity in target-agnostic cellular assays and monitoring changes in phenotype followed by identification of the biological target are a powerful approach for the identification of novel bioactive che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be09301612a26f71d7b6806277269021
https://doi.org/10.1021/acs.jmedchem.2c00956
https://doi.org/10.1021/acs.jmedchem.2c00956
Autor:
Yen-Chun Lee, Sumersing Patil, Christopher Golz, Carsten Strohmann, Slava Ziegler, Kamal Kumar, Herbert Waldmann
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Synthetic methods that efficiently construct structurally diverse molecular scaffolds are attractive routes to diversely bioactive molecules. Here the authors report a method whereby common starting materials are converted to structurally and functio
Externí odkaz:
https://doaj.org/article/d1bf46a4d848459f9c5dd08e325677dc
Autor:
Axel Pahl, Jie Liu, Sohan Patil, Soheila Rezaei Adariani, Beate Scholermann, Jana Bonowski, Sandra Koska, Sonja Sievers, Jens Warmers, Slava Ziegler, Herbert Waldmann
The identification of bioactive small molecules is at the heart of chemical biology and medicinal research. The screening for modulators of disease-relevant targets and phenotypes is the first step on the way to new drugs. Therefore, large compound l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dce5b2917cea0fd68fc989942354ceb
https://doi.org/10.1101/2023.05.31.542818
https://doi.org/10.1101/2023.05.31.542818
Autor:
Jie Liu, Shubhadip Mallick, Yusheng Xie, Corentin Grassin, Belén Lucas, Beate Schölermann, Axel Pahl, Rebecca Scheel, Carsten Strohmann, Christoph Protzel, Thorsten Berg, Christian Merten, Slava Ziegler, Herbert Waldmann
Publikováno v:
Angewandte Chemie International Edition. 62
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b96dd05a4b7802c5fde8b1ae86e5cf
https://doi.org/10.1002/anie.202301955
https://doi.org/10.1002/anie.202301955
Autor:
Kirsten Tschapalda, Ya-Qin Zhang, Li Liu, Kseniya Golovnina, Thomas Schlemper, Thomas O. Eichmann, Madhu Lal-Nag, Urmila Sreenivasan, John McLenithan, Slava Ziegler, Carole Sztalryd, Achim Lass, Douglas Auld, Brian Oliver, Herbert Waldmann, Zhuyin Li, Min Shen, Matthew B. Boxer, Mathias Beller
Publikováno v:
EBioMedicine, Vol 8, Iss C, Pp 49-59 (2016)
Excess lipid storage is an epidemic problem in human populations. Thus, the identification of small molecules to treat or prevent lipid storage-related metabolic complications is of great interest. Here we screened >320.000 compounds for their abilit
Externí odkaz:
https://doaj.org/article/6d353b3c4e674fdc8ba176664da784f4
Autor:
Damir Jacob Illich, Miao Zhang, Andrei Ursu, Rodrigo Osorno, Kee-Pyo Kim, Juyong Yoon, Marcos J. Araúzo-Bravo, Guangming Wu, Daniel Esch, Davood Sabour, Douglas Colby, Kathrin S. Grassme, Jiayu Chen, Boris Greber, Susanne Höing, Wiebke Herzog, Slava Ziegler, Ian Chambers, Shaorong Gao, Herbert Waldmann, Hans R. Schöler
Publikováno v:
Cell Reports, Vol 15, Iss 4, Pp 787-800 (2016)
It has previously been reported that mouse epiblast stem cell (EpiSC) lines comprise heterogeneous cell populations that are functionally equivalent to cells of either early- or late-stage postimplantation development. So far, the establishment of th
Externí odkaz:
https://doaj.org/article/bcd0b9b6536d410aacc68d28af505701
Autor:
Beate Schölermann, Jana Bonowski, Michael Grigalunas, Annina Burhop, Yusheng Xie, Joseph G. F. Hoock, Jie Liu, Mark Dow, Adam Nelson, Christine Nowak, Axel Pahl, Sonja Sievers, Slava Ziegler
Publikováno v:
Chembiochem : a European journal of chemical biology. 23(22)
Profiling approaches have been increasingly employed for the characterization of disease-relevant phenotypes or compound perturbation as they provide a broad, unbiased view on impaired cellular states. We report that morphological profiling using the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce0cec5ddccf6b65a1c00c820ac2b36
https://pubmed.ncbi.nlm.nih.gov/36134475
https://pubmed.ncbi.nlm.nih.gov/36134475
Autor:
Axel Pahl, Beate Schölermann, Marion Rusch, Mark Dow, Christian Hedberg, Adam Nelson, Sonja Sievers, Herbert Waldmann, Slava Ziegler
Fast prediction of mode of action for bioactive compounds would immensely foster bioactivity annotation in compound collections and may early on reveal off-targets in chemical biology research and drug discovery. A variety of target-based assays is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b16c98b588e1e34f9d1976b176c1f7e
https://doi.org/10.1101/2022.08.15.503944
https://doi.org/10.1101/2022.08.15.503944
Autor:
Michael Grigalunas, Sohan Patil, Adrian Krzyzanowski, Axel Pahl, Jana Flegel, Beate Schölermann, Jianing Xie, Sonja Sievers, Slava Ziegler, Herbert Waldmann
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 28(67)
Pseudo-natural products (pseudo-NPs) are de novo combinations of natural product (NP) fragments that define novel bioactive chemotypes. For their discovery, new design principles are being sought. Previously, pseudo-NPs were synthesized by the combin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e71994096381f899a433553cad8933
https://pubmed.ncbi.nlm.nih.gov/36083197
https://pubmed.ncbi.nlm.nih.gov/36083197