Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Slava, Epelman"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Cardiac fibroblasts play an essential role in the development of the heart and are implicated in disease progression in the context of fibrosis and regeneration. Here, we establish a simple organoid culture platform using human pluripotent s
Externí odkaz:
https://doaj.org/article/c39b4183f42849b3bb6e03b1a455fe02
Autor:
Kexin Peng, Beibei Du, Daoyuan Si, Lina Jin, Bo Yang, Neil Johnson, Lujia Ni, Qian Zhang, Mohammed Ali Azam, Patrick F. H. Lai, Slava Epelman, Kumaraswamy Nanthakumar, Ping Yang
Publikováno v:
Cardiovascular Innovations and Applications, Vol 9, Iss 1, p 975 (2024)
Background: We previously described the mortality associated with cardiac injury in patients with coronavirus disease 2019 (COVID-19). The activation of immune and thrombotic biomarkers at admission, and their ability to predict cardiac injury and mo
Externí odkaz:
https://doaj.org/article/fabb21c1118648a889ed223f2ec2fedd
Autor:
Christiane Pleuger, Dingding Ai, Minea L Hoppe, Laura T Winter, Daniel Bohnert, Dominik Karl, Stefan Guenther, Slava Epelman, Crystal Kantores, Monika Fijak, Sarina Ravens, Ralf Middendorff, Johannes U Mayer, Kate L Loveland, Mark Hedger, Sudhanshu Bhushan, Andreas Meinhardt
Publikováno v:
eLife, Vol 11 (2022)
The epididymis functions as transition zone for post-testicular sperm maturation and storage and faces contrasting immunological challenges, i.e. tolerance towards spermatozoa vs. reactivity against pathogens. Thus, normal organ function and integrit
Externí odkaz:
https://doaj.org/article/a41d07b05a714c4997aefbc4d9a009e5
Autor:
Ping Yan, Ki-Wook Kim, Qingli Xiao, Xiucui Ma, Leah R. Czerniewski, Haiyan Liu, David R. Rawnsley, Yan Yan, Gwendalyn J. Randolph, Slava Epelman, Jin-Moo Lee, Abhinav Diwan
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 11 (2022)
Microglia, the parenchymal tissue macrophages in the brain, surround amyloid plaques in brains of individuals with Alzheimer’s disease (AD) but are ineffective at clearing amyloid to mitigate disease progression. Recent studies in mice indicate tha
Externí odkaz:
https://doaj.org/article/27704bd3066749ef9a3e3a8ea5e14f2b
Autor:
Sheojung Shin, Peter C. Austin, Heather J. Ross, Husam Abdel‐Qadir, Cassandra Freitas, George Tomlinson, Davide Chicco, Meera Mahendiran, Patrick R. Lawler, Filio Billia, Anthony Gramolini, Slava Epelman, Bo Wang, Douglas S. Lee
Publikováno v:
ESC Heart Failure, Vol 8, Iss 1, Pp 106-115 (2021)
Abstract Aims This study aimed to review the performance of machine learning (ML) methods compared with conventional statistical models (CSMs) for predicting readmission and mortality in patients with heart failure (HF) and to present an approach to
Externí odkaz:
https://doaj.org/article/05569e888d6345f290ccb149a195e7f1
Autor:
Rysa Zaman, Slava Epelman
Publikováno v:
Immunity. 55:1549-1563
Understanding tissue macrophage biology has become challenging in recent years due the ever-increasing complexity in macrophage-subset identification and functional characterization. This is particularly important within the myocardium, as we have co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dcb3eed4ea690515379fe7da8059ad4
https://doi.org/10.1016/j.immuni.2022.08.009
https://doi.org/10.1016/j.immuni.2022.08.009
Autor:
Ismail Sergin, Trent D. Evans, Xiangyu Zhang, Somashubhra Bhattacharya, Carl J. Stokes, Eric Song, Sahl Ali, Babak Dehestani, Karyn B. Holloway, Paul S. Micevych, Ali Javaheri, Jan R. Crowley, Andrea Ballabio, Joel D. Schilling, Slava Epelman, Conrad C. Weihl, Abhinav Diwan, Daping Fan, Mohamed A. Zayed, Babak Razani
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-20 (2017)
Dysfunction of autophagy in plaque macrophages aggravates atherosclerosis. Here the authors show that induction of macrophage autophagy–lysosomal biogenesis either genetically by overexpression of the master transcriptional regulator of this proces
Externí odkaz:
https://doaj.org/article/2386c202410647229c348496bc117d5b
Autor:
Anthony Wong, Slava Epelman
Publikováno v:
Nature Cardiovascular Research. 1:1111-1113
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd50b3bc81b6757176edefe2cd3b3dcf
https://doi.org/10.1038/s44161-022-00184-9
https://doi.org/10.1038/s44161-022-00184-9
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
High dimensional approaches that characterize single cells at unprecedented depth have helped uncover unappreciated heterogeneity, a better understanding of myeloid cell origins, developmental relationships and functions. These advancements are parti
Externí odkaz:
https://doaj.org/article/46356770d4d146a88161492dbd49e1f9
Publikováno v:
JACC: Basic to Translational Science, Vol 2, Iss 6, Pp 699-701 (2017)
Externí odkaz:
https://doaj.org/article/e16ec391cbeb4a6f816f97ca7cd08541