A protein-free vaccine stimulates innate immunity and protects against nosocomial pathogens.

Autor: Yan J; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Nielsen TB; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; UC San Diego School of Medicine, University of California San Diego, San Diego, CA 92093, USA., Lu P; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Talyansky Y; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Slarve M; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Reza H; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Novakovic B; Murdoch Children's Research Institute and Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Parkville, VIC 3052, Australia., Netea MG; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.; Department of Immunology and Metabolism, Life and Medical Sciences Institute, University of Bonn, 53115 Bonn, Germany., Keller AE; AstraZeneca Inc., Early Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA., Warren T; AstraZeneca Inc., Early Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA., DiGiandomenico A; AstraZeneca Inc., Early Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA., Sellman BR; AstraZeneca Inc., Early Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA., Luna BM; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Spellberg B; Los Angeles General Medical Center, Los Angeles, CA 90033, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2023 Oct 04; Vol. 15 (716), pp. eadf9556. Date of Electronic Publication: 2023 Oct 04.

Therapeutic, Humanized Monoclonal Antibody Exhibits Broad Binding and Protective Efficacy against Acinetobacter baumannii.

Autor: Slarve M; Department of Molecular Microbiology and Immunology, Keck School of Medicine of USC, Los Angeles, California, USA., Reyna Z; Department of Molecular Microbiology and Immunology, Keck School of Medicine of USC, Los Angeles, California, USA., Burk E; Department of Molecular Microbiology and Immunology, Keck School of Medicine of USC, Los Angeles, California, USA., Ruiz-Delgado J; Department of Molecular Microbiology and Immunology, Keck School of Medicine of USC, Los Angeles, California, USA., Li R; Department of Molecular Microbiology and Immunology, Keck School of Medicine of USC, Los Angeles, California, USA., Yan J; Department of Molecular Microbiology and Immunology, Keck School of Medicine of USC, Los Angeles, California, USA., Luna B; Department of Molecular Microbiology and Immunology, Keck School of Medicine of USC, Los Angeles, California, USA., Spellberg B; Los Angeles County-USC (LAC+USC) Medical Center, Los Angeles, California, USA.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2023 Mar 16; Vol. 67 (3), pp. e0008623. Date of Electronic Publication: 2023 Feb 28.

Acacia Fiber Protects the Gut from Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli Colonization Enabled by Antibiotics.

Autor: Maeusli M; Department of Medicine, Keck School of Medicine, University of Southern Californiagrid.42505.36 (USC), Los Angeles, California, USA.; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern Californiagrid.42505.36 (USC), Los Angeles, California, USA., Skandalis N; Department of Medicine, Keck School of Medicine, University of Southern Californiagrid.42505.36 (USC), Los Angeles, California, USA., Lee B; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern Californiagrid.42505.36 (USC), Los Angeles, California, USA., Lu P; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern Californiagrid.42505.36 (USC), Los Angeles, California, USA., Miller S; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern Californiagrid.42505.36 (USC), Los Angeles, California, USA., Yan J; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern Californiagrid.42505.36 (USC), Los Angeles, California, USA., Talyansky Y; Department of Medicine, Keck School of Medicine, University of Southern Californiagrid.42505.36 (USC), Los Angeles, California, USA.; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern Californiagrid.42505.36 (USC), Los Angeles, California, USA., Li R; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern Californiagrid.42505.36 (USC), Los Angeles, California, USA., Reyna Z; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern Californiagrid.42505.36 (USC), Los Angeles, California, USA., Guerrero N; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern Californiagrid.42505.36 (USC), Los Angeles, California, USA., Ulhaq A; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern Californiagrid.42505.36 (USC), Los Angeles, California, USA., Slarve M; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern Californiagrid.42505.36 (USC), Los Angeles, California, USA., Theologidis I; Department of Biology, National and Kapodistrian University of Athens, Athens, Greece., Spellberg B; Los Angeles County + University of Southern Californiagrid.42505.36 Medical Center, Los Angeles, California, USA., Luna B; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern Californiagrid.42505.36 (USC), Los Angeles, California, USA.

Publikováno v: MSphere [mSphere] 2022 Jun 29; Vol. 7 (3), pp. e0007122. Date of Electronic Publication: 2022 May 18.

Monoclonal Antibody Therapy against Acinetobacter baumannii .

Autor: Nielsen TB; Stritch School of Medicine, Loyola University Chicagogrid.164971.c, Maywood, Illinois, USA.; Parkinson School of Health Sciences and Public Health, Loyola University Chicagogrid.164971.c, Maywood, Illinois, USA.; Department of Molecular Microbiology & Immunology, Keck School of Medicine at the University of Southern Californiagrid.42505.36, Los Angeles, California, USA., Yan J; Department of Molecular Microbiology & Immunology, Keck School of Medicine at the University of Southern Californiagrid.42505.36, Los Angeles, California, USA., Slarve M; Department of Molecular Microbiology & Immunology, Keck School of Medicine at the University of Southern Californiagrid.42505.36, Los Angeles, California, USA., Lu P; Department of Molecular Microbiology & Immunology, Keck School of Medicine at the University of Southern Californiagrid.42505.36, Los Angeles, California, USA., Li R; Department of Molecular Microbiology & Immunology, Keck School of Medicine at the University of Southern Californiagrid.42505.36, Los Angeles, California, USA., Ruiz J; Department of Molecular Microbiology & Immunology, Keck School of Medicine at the University of Southern Californiagrid.42505.36, Los Angeles, California, USA., Lee B; Department of Molecular Microbiology & Immunology, Keck School of Medicine at the University of Southern Californiagrid.42505.36, Los Angeles, California, USA., Burk E; Department of Molecular Microbiology & Immunology, Keck School of Medicine at the University of Southern Californiagrid.42505.36, Los Angeles, California, USA., Talyansky Y; Department of Molecular Microbiology & Immunology, Keck School of Medicine at the University of Southern Californiagrid.42505.36, Los Angeles, California, USA., Oelschlaeger P; Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciencesgrid.268203.d, Pomona, California, USA., Hurth K; Department of Pathology, Keck School of Medicine at the University of Southern Californiagrid.42505.36, Los Angeles, California, USA., Win W; Department of Pathology, Keck School of Medicine at the University of Southern Californiagrid.42505.36, Los Angeles, California, USA., Luna BM; Department of Molecular Microbiology & Immunology, Keck School of Medicine at the University of Southern Californiagrid.42505.36, Los Angeles, California, USA., Bonomo RA; Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.; Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.; Departments of Pharmacology, Molecular Biology and Microbiology, Biochemistry, and Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, Ohio, USA., Spellberg B; Los Angeles County and University of Southern Californiagrid.42505.36 Medical Center, Los Angeles, California, USA.

Publikováno v: Infection and immunity [Infect Immun] 2021 Sep 16; Vol. 89 (10), pp. e0016221. Date of Electronic Publication: 2021 Jul 26.

Synergistic Rifabutin and Colistin Reduce Emergence of Resistance When Treating Acinetobacter baumannii.

Autor: Cheng J; Department of Molecular Microbiology and Immunology, Keck School of Medicine at USC, Los Angeles, California, USA., Yan J; Department of Molecular Microbiology and Immunology, Keck School of Medicine at USC, Los Angeles, California, USA., Reyna Z; Department of Molecular Microbiology and Immunology, Keck School of Medicine at USC, Los Angeles, California, USA., Slarve M; Department of Molecular Microbiology and Immunology, Keck School of Medicine at USC, Los Angeles, California, USA., Lu P; Department of Molecular Microbiology and Immunology, Keck School of Medicine at USC, Los Angeles, California, USA., Spellberg B; Los Angeles County-USC (LAC+USC) Medical Center, Los Angeles, California, USA., Luna B; Department of Molecular Microbiology and Immunology, Keck School of Medicine at USC, Los Angeles, California, USA brian.luna@usc.edu.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2021 Mar 18; Vol. 65 (4). Date of Electronic Publication: 2021 Mar 18 (Print Publication: 2021).