Research Note: Clostridium perfringens NetB and CnaA neutralizing nanobodies in feed reduce the incidence of poultry necrotic enteritis

Autor: Slade A. Loutet, Sylvia Cheung, Sarah Zaytsoff, Charles Hofacre, Matthew K. Jones, Filip Van Petegem, Hamlet Abnousi

Publikováno v: Poultry Science, Vol 103, Iss 4, Pp 103578- (2024)

ABSTRACT: Necrotic enteritis is a devastating disease to poultry caused by the bacterium Clostridium perfringens. As a novel approach to combating poultry necrotic enteritis, we identified and characterized several hundred single domain antibody frag

Externí odkaz: https://doaj.org/article/a023282a5da74fd6b6be85105500bebc

Extreme antimicrobial peptide and polymyxin B resistance in the genus Burkholderia

Autor: Slade A. Loutet, Miguel A Valvano

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 1 (2011)

Cationic antimicrobial peptides and polymyxins are a group of naturally occurring antibiotics that can also possess immunomodulatory activities. They are considered a new source of antibiotics for treating infections by bacteria that are resistant to

Externí odkaz: https://doaj.org/article/f348bac103de4059905d33071e3c187b

Identification of synergists that potentiate the action of polymyxin B against Burkholderia cenocepacia

Autor: José María Sánchez López, Julian Davies, Omar M. El-Halfawy, Antonio Fernández Medarde, Agatha N. Jassem, David P. Speert, Miguel A. Valvano, Slade A. Loutet

Publikováno v: Loutet, S A, El-Halfawy, O M, Jassem, A N, Sánchez López, J M, Fernández Medarde, A, Speert, D P, Davies, J E & Valvano, M A 2015, ' Identification of synergists that potentiate the action of polymyxin B against Burkholderia cenocepacia ', International Journal of Antimicrobial Agents, vol. 46, no. 4, pp. 376-380 . https://doi.org/10.1016/j.ijantimicag.2015.05.010

Burkholderia cenocepacia and other members of the Burkholderia cepacia complex (Bcc) are highly multidrug-resistant bacteria that cause severe pulmonary infections in patients with cystic fibrosis. A screen of 2686 compounds derived from marine organ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd161747b04edce89d926d47dcb659f8
https://doi.org/10.1016/j.ijantimicag.2015.05.010

Iron Uptake Oxidoreductase (IruO) Uses a Flavin Adenine Dinucleotide Semiquinone Intermediate for Iron-Siderophore Reduction

Autor: Marek J. Kobylarz, Graham A. Heieis, Michael E. P. Murphy, Slade A. Loutet

Publikováno v: ACS chemical biology. 12(7)

Many pathogenic bacteria including Staphylococcus aureus use iron-chelating siderophores to acquire iron. Iron uptake oxidoreductase (IruO), a flavin adenine dinucleotide (FAD)-containing nicotinamide adenine dinucleotide phosphate (NADPH)-dependent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb83dc2362e3e4e5c0bef0d04df21326
https://pubmed.ncbi.nlm.nih.gov/28463500

Burkholderia cenocepacia O polysaccharide chain contributes to caspase-1-dependent IL-1β production in macrophages

Autor: Basant A. Abdulrahman, Benjamin T. Kopp, Amal O. Amer, Ximena Ortega, Dalia H. A. Abdelaziz, Sheetal Kotrange, Clay B. Marsh, Kyle Caution, Slade A. Loutet, Arwa Abu Khweek, Anwari Akhter, Mark D. Wewers, Miguel A. Valvano, Karen McCoy

Publikováno v: Journal of Leukocyte Biology. 89:481-488

Burkholderia cenocepacia infections in CF patients involve heightened inflammation, fatal sepsis, and high antibiotic resistance. Proinflammatory IL-1β secretion is important in airway inflammation and tissue damage. However, little is known about t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae4c5ddbd55abfbb0366edf42fc26f86
https://doi.org/10.1189/jlb.0910513