Atypical sympathomimetic drug lerimazoline mediates contractile effects in rat aorta predominantly by 5-HT2A receptors

Autor: Eldina Rizvić, Goran Janković, Slađana Kostić-Rajačić, Miroslav M. Savić

Publikováno v: Biomolecules & Biomedicine, Vol 17, Iss 3 (2017)

Lerimazoline is a sympathomimetic drug that belongs to the imidazoline class of compounds, and is used as a nasal decongestant. Studies on lerimazoline are rare, and its pharmacological profile is not completely understood. Here, we analyzed the affi

Externí odkaz: https://doaj.org/article/c95258cf8b8147f9ba8bedb50d0c154e

Design, Synthesis and Pharmacological Evaluation of novel N-{4-[2-(4-aryl-piperazin-1-yl)-ethyl]-phenyl}-arylamides

Autor: Slađana Dukić-Stefanovic, Relja Suručić, V. Šukalović, Jelena Penjišević, Slađana Kostić-Rajačić, Deana Andrić, Ivana I. Jevtić

Publikováno v: Book of proceedings-1st International Conference on Chemo and Bioinformatics, October 26-27, 2021. Kragujevac
1st International Conference on Chemo and BioInformatics (ICCBIKG 2021), Kragujevac, Serbia, 26-27th October 2021

5HT1A receptor targeting drugs have been used as the treatment for the many neuropsychiatric disorders, such as schizophrenia and depression. As a part of ongoing research, we designed series of new compounds that share arylpiperazine common structur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f582493c273f7aea4f683e0ba4c43d9
https://cer.ihtm.bg.ac.rs/handle/123456789/5849

Synthesis and pharmacological evaluation of novel cis and trans 3-substituted anilidopiperidines

Autor: Katarina Savić Vujović, Ivana I. Jevtić, Slađana Kostić-Rajačić, Dragana Srebro, Milovan D. Ivanović, Sonja Vučković

Publikováno v: Pharmacological Reports

Background 4-Anilidopiperidine class of synthetic opioid analgesics, with it’s representative fentanyl, are by far the most potent and clinically significant for the treatment of the severe chronic and surgical pain. However, side effects of μ-opi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::552d4d40dfc43df3da959a41c9bd9b95
https://pubmed.ncbi.nlm.nih.gov/32613543

Synthesis, Biological, and Computational Evaluation of Substituted 1-(2-Methoxyphenyl)-4-(1-phenethylpiperidin-4-yl)piperazines and 1-(2-Methoxyphenyl)-4-[(1-phenethylpiperidin-4-yl)methyl]piperazines as Dopaminergic Ligands

Autor: Jelena Penjišević, Slađana Kostić-Rajačić, Goran Roglić, Deana Andrić, Vladimir Sukalovic, Vukic Soskic

Publikováno v: Archiv der Pharmazie. 349:614-626

Sixteen new 1-(2-methoxyphenyl)-4-(1-phenethylpiperidin-4-yl)piperazines and 1-(2-methoxyphenyl)-4-[(1-phenethylpiperidin-4-yl)methyl]piperazines were synthesized to be used as probes for mapping the dopamine D2 receptor (D2 DAR) arylpiperazine bindi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::03c9d9e79582cc19cd5dc073ea642505
https://doi.org/10.1002/ardp.201600081

The mechanisms responsible for neuroprotective capacity of arylpiperazine dopaminergic ligands against cell death induced by sodium nitroprusside

Autor: Marija Slavić, Mirko Tomić, Aleksandra Nikolić-Kokić, Deana Andrić, Đurđica Ignjatović, Danijela Vojnović Milutinović, Slađana Kostić-Rajačić

Publikováno v: European Journal of Pharmacology

A group of sixteen arylpiperazines had been previously synthesized and evaluated for atypical antipsychotic activity. Here we examined these compounds for their neuroprotective capacity. The affinity and agonist/antagonist action of the arylpiperazin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155c9cd9eb2aefa7efac31420931b398
https://cherry.chem.bg.ac.rs/handle/123456789/1289